AL amyloidosis

A plasma cell disorder characterized by the aggregation and deposition of insoluble amyloid fibrils derived from misfolding of monoclonal immunoglobulin light chains usually produced by a plasma cell tumor. It usually presents as primary systemic amyloidosis (PSA) with multiple organ involvement and less frequently as primary localized amyloidosis (PLA) restricted to a single organ.

Edema

An abnormal accumulation of fluid beneath the skin, or in one or more cavities of the body.


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(per page)
PMID (PMCID)
29795248
(5966459)
 FEMALE
Immunoglobulin light chain amyloidosis diagnosis and treatment algorithm 2018.
Gertz MA.
Blood Cancer J. 2018;8(5):44.
MGUS and myeloma patients that have atypical features, including unexplained weight loss; lower extremity edema, early satiety, and dyspnea on exertion should be considered at risk for light chain amyloidosis.
23237236
 FEMALE Adult
How nature preserves fetuses.
Adami F, Fedrigo M, Gervasi MT, Verga L, Coccato M, Lessi F, Angelini A, Daliento L.
Amyloid. 2013;20(1):56-7.
We report on a young pregnant woman developing distal leg edema and hypoalbuminemia, who was lately diagnosed with AL amyloidosis.
24452148
 MALE Middle Aged
[Rapidly progressive AL amyloidosis in a patient with relapsed multiple myeloma after achieving a complete response to tandem autologous PBSCT].
Yagi H, Ozaki S, Sekimoto E, Shibata H, Shigekiyo T, Satake N.
Rinsho Ketsueki. 2013;54(12):2171-6.
In 2012, he developed edema of the lower legs and pleural effusion, and was diagnosed as having nephrotic syndrome and heart failure due to AL amyloidosis.