AL amyloidosis

A plasma cell disorder characterized by the aggregation and deposition of insoluble amyloid fibrils derived from misfolding of monoclonal immunoglobulin light chains usually produced by a plasma cell tumor. It usually presents as primary systemic amyloidosis (PSA) with multiple organ involvement and less frequently as primary localized amyloidosis (PLA) restricted to a single organ.

Hyperreflexia

Hyperreflexia is the presence of hyperactive stretch reflexes of the muscles.

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PMID (PMCID)
3016605	MALE	Middle Aged
	Primary amyloidosis with peripheral neuropathy and signs of motor neuron disease.
	Abarbanel JM, Frisher S, Osimani A. Neurology. 1986;36(8):1125-7.
	A 51-year-old man had primary amyloidosis, with typical amyloid neuropathy and signs of motor neuron disease, including widespread fasciculation in limb muscles, tongue atrophy and fasciculation, swallowing and chewing difficulty, symmetric hyperreflexia, and bilateral Hoffmann's signs.