AL amyloidosis

A plasma cell disorder characterized by the aggregation and deposition of insoluble amyloid fibrils derived from misfolding of monoclonal immunoglobulin light chains usually produced by a plasma cell tumor. It usually presents as primary systemic amyloidosis (PSA) with multiple organ involvement and less frequently as primary localized amyloidosis (PLA) restricted to a single organ.

Weight loss

Reduction inexisting body weight.


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PMID (PMCID)
30477388
 FEMALE Adult
Daratumumab, pomalidomide, and dexamethasone as a bridging therapy to autologous stem cell transplantation in a case of systemic light-chain amyloidosis with advanced cardiac involvement.
Arnall JR, Usmani SZ, Adamu H, Mishkin J, Bhutani M.
J Oncol Pharm Pract. 2019;25(4):1021-1025.
A 43-year-old female with light-chain amyloidosis and concomitant multiple myeloma presented with severe bowel dysmotility causing abdominal pain, anemia, and a 100-pound unintentional weight loss.
29795248
(5966459)
 FEMALE
Immunoglobulin light chain amyloidosis diagnosis and treatment algorithm 2018.
Gertz MA.
Blood Cancer J. 2018;8(5):44.
MGUS and myeloma patients that have atypical features, including unexplained weight loss; lower extremity edema, early satiety, and dyspnea on exertion should be considered at risk for light chain amyloidosis.
23617890
(3641022)
 MALE Adult
Chronic diarrhea as the presenting feature of primary systemic AL amyloidosis: serendipity or delayed diagnosis?
Wang C, Li Y, Jin Y, Zhou W, Zhu Y, Yao F, Qian J.
BMC Gastroenterol. 2013;13:71.
We report a case of primary systemic amyloid light-chain (AL) amyloidosis, presenting initially as chronic diarrhea and weight loss.
21349611
 MALE Middle Aged
[Seriousness of AL amyloidosis of the digestive system].
Pavic M, Camus C, Pasquet F, Karkowski L, Galoo E, Nibaud A, Debourdeau P.
Rev Med Interne. 2011;32(4):e52-4.
We report a 64-year-old patient, presenting with a weight loss related to an AL amyloidosis.