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AL amyloidosis

A plasma cell disorder characterized by the aggregation and deposition of insoluble amyloid fibrils derived from misfolding of monoclonal immunoglobulin light chains usually produced by a plasma cell tumor. It usually presents as primary systemic amyloidosis (PSA) with multiple organ involvement and less frequently as primary localized amyloidosis (PLA) restricted to a single organ.

Azotemia

An increased concentration of nitrogen compounds in the blood.

Total: 1

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PMID (PMCID)
18452093	MIXED_SAMPLE	Adult
	Azotemia associated with use of lenalidomide in plasma cell dyscrasias.
	Batts ED, Sanchorawala V, Hegerfeldt Y, Lazarus HM. Leuk Lymphoma. 2008;49(6):1108-15.
	We describe five patients with plasma cell dyscrasias and renal insufficiency (AL amyloidosis, monoclonal gammopathy of undetermined significance with Fanconi syndrome, and multiple myeloma) treated with lenalidomide and dexamethasone who developed progressive azotemia.