AL amyloidosis

A plasma cell disorder characterized by the aggregation and deposition of insoluble amyloid fibrils derived from misfolding of monoclonal immunoglobulin light chains usually produced by a plasma cell tumor. It usually presents as primary systemic amyloidosis (PSA) with multiple organ involvement and less frequently as primary localized amyloidosis (PLA) restricted to a single organ.

Fasciculations

Fasciculations are observed as small, local, involuntary muscle contractions (twitching) visible under the skin. Fasciculations result from increased irritability of an axon (which in turn is often a manifestation of disease of a motor neuron). This leads to sporadic discharges of all the muscle fibers controlled by the axon in isolation from other motor units.

Total: 2

(per page)

PMID (PMCID)
3016605	MALE	Middle Aged
	Primary amyloidosis with peripheral neuropathy and signs of motor neuron disease.
	Abarbanel JM, Frisher S, Osimani A. Neurology. 1986;36(8):1125-7.
	A 51-year-old man had primary amyloidosis, with typical amyloid neuropathy and signs of motor neuron disease, including widespread fasciculation in limb muscles, tongue atrophy and fasciculation, swallowing and chewing difficulty, symmetric hyperreflexia, and bilateral Hoffmann's signs.
3016605	MALE	Middle Aged
	Primary amyloidosis with peripheral neuropathy and signs of motor neuron disease.
	Abarbanel JM, Frisher S, Osimani A. Neurology. 1986;36(8):1125-7.
	A 51-year-old man had primary amyloidosis, with typical amyloid neuropathy and signs of motor neuron disease, including widespread fasciculation in limb muscles, tongue atrophy and fasciculation, swallowing and chewing difficulty, symmetric hyperreflexia, and bilateral Hoffmann's signs.