AA amyloidosis

Secondary amyloidosis is a form of amyloidosis (see this term), that complicates chronic inflammatory disorders (mainly rheumatoid arthritis, see this term) and is characterized by the aggregation and deposition of amyloid fibrils composed of serum amyloid A protein, an acute phase reactant. Although spleen, suprarenal gland, liver and gut are frequent sites of amyloid deposition, the clinical picture is dominated by renal involvement.

Proteinuria

Increased levels of protein in the urine.

Total: 19

(per page)

PMID (PMCID)
26819362	FEMALE	Middle Aged
	Amyloid A amyloidosis secondary to hyper IgD syndrome and response to IL-1 blockage therapy.
	Kallianidis AF, Ray A, Goudkade D, de Fijter JW. Neth J Med. 2016;74(1):43-6.
	This case demonstrates that AA amyloidosis does occur in patients with HIDS and can present with intestinal symptoms and proteinuria.
24510061	MALE	Adult
	Renal involvement in secondary amyloidosis of Muckle-Wells syndrome: marked improvement of renal function and reduction of proteinuria after therapy with human anti-interleukin-1beta monoclonal antibody canakinumab.
	Scarpioni R, Rigante D, Cantarini L, Ricardi M, Albertazzi V, Melfa L, Lazzaro A. Clin Rheumatol. 2015;34(7):1311-6.
	Renal involvement in secondary amyloidosis of Muckle-Wells syndrome: marked improvement of renal function and reduction of proteinuria after therapy with human anti-interleukin-1946 monoclonal antibody canakinumab.
25340157 (4206034)	OTHER
	Amyloid A amyloidosis with subcutaneous drug abuse.
	Mendoza JM, Peev V, Ponce MA, Thomas DB, Nayer A. J Renal Inj Prev. 2014;3(1):11-6.
	The manifestations of AA amyloidosis involving the kidneys include proteinuria, tubular dysfunction and progressive loss of renal function.
25174445	MALE
	De novo amyloidosis in a renal transplant patient.
	Ylmaz S, Ozcakar ZB, Bulum B, Kiremitci S, Ensari A, Ekim M, Keven K, Yalcnkaya F. Pediatr Transplant. 2014;18(8):E259-61.
	Three yr after transplantation, renal biopsy was performed for proteinuria and AA amyloidosis was identified in the renal allograft.
23439243	MALE	Adult
	AA amyloid nephropathy with predominant vascular deposition in Crohn's disease.
	Kurita N, Kotera N, Ishimoto Y, Tanaka M, Tanaka S, Toda N, Fujii A, Kobayashi K, Sugimoto T, Mise N. Clin Nephrol. 2013;79(3):229-32.
	AA amyloidosis is typically accompanied by glomerular amyloid deposition and massive proteinuria.
24435036	MALE	Adult
	The effect of etanercept on a case of amyloidosis secondary to ankylosing spondylitis: results of 2-year follow-up.
	Yilmaz H, Kocabas H, Erkin G. Acta Reumatol Port. 2013;38(4):299-301.
	Secondary amyloidosis (type AA) is rarely encountered but can be a significant complication of ankylosing spondylitis (AS) and may lead to proteinuria and renal dysfunction.
25984125 (4421567)	OTHER
	AA amyloidosis in a patient with Langerhans cell histiocytosis.
	Thomson PC, Taylor AH, Morris ST, Kipgen D, Mactier RA. NDT Plus. 2011;4(2):104-6.
	We report the case of a 37-year-old woman who presented with progressive renal dysfunction and proteinuria, in whom renal biopsy confirmed a diagnosis of AA amyloidosis.
21992511	MALE	Adult
	Successful use of tocilizumab in a patient with nephrotic syndrome due to a rapidly progressing AA amyloidosis secondary to latent tuberculosis.
	Magro-Checa C, Navas-Parejo Casado A, Borrego-Garcia E, Raya-Alvarez E, Rosales-Alexander JL, Salvatierra J, Caballero-Morales T, Gomez-Morales M. Amyloid. 2011;18(4):235-9.
	After an adequate antituberculostatic treatment, AA amyloidosis remained active and Tocilizumab (TCZ) was started with a dramatic resolution of the proteinuria, stabilization of the amyloid deposits and improvement in general condition.
19689697	MALE	Adult
	Crohn's disease and secondary amyloidosis: early complication? A case report and review of the literature.
	Basturk T, Ozagari A, Ozturk T, Kusaslan R, Unsal A. J Ren Care. 2009;35(3):147-50.
	In this case, we estimate secondary amyloidosis occurred before Crohn's disease or early Crohn's disease complication, based on the fact that hypoalbuminaemia and proteinuria was detected approximately one year after the start of gastrointestinal complaints.
19883900	FEMALE	Middle Aged
	[Amyloid goiter secondary to Crohn's disease].
	Gallardo GL, Moya MP, Rey MD, Arroyo MJ, Davila FM, Sanchez-Covisa MA. Endocrinol Nutr. 2009;56(7):384-6.
	Most cases of secondary amyloidosis are discovered due to proteinuria or nephrotic syndrome caused by renal amyloidosis.
17611708	MIXED_SAMPLE	Middle Aged
	Ankylosing spondylitis-related secondary amyloidosis responded well to etanercept: a report of three patients.
	Kobak S, Oksel F, Kabasakal Y, Doganavsargil E. Clin Rheumatol. 2007;26(12):2191-2194.
	Secondary (AA) amyloidosis is one of the most significant complications of ankylosing spondylitis (AS) that frequently leads to proteinuria and renal dysfunction.
16308343	MIXED_SAMPLE	Adult
	"Periodic fever" without fever: two cases of non-febrile TRAPS with mutations in the TNFRSF1A gene presenting with episodes of inflammation or monosymptomatic amyloidosis.
	Kallinich T, Haffner D, Rudolph B, Schindler R, Canaan-Kuhl S, Keitzer R, Burmester GR, Roesen-Wolff A, Roesler J. Ann Rheum Dis. 2006;65(7):958-60.
	A medical check up showed proteinuria, and renal biopsy disclosed AA amyloidosis.
17228804	MALE	Middle Aged
	[A case of Behcet disease with multiple nodular shadows and aneurysm of the brachiocephalic trunk caused by necrotizing vasculitis].
	Kato E, Isobe Y, Mizuno A, Wakayama H, Ogasawara T, Suzuki M, Shimizu S, Niimi T, Sato S, Ueda R. Nihon Kokyuki Gakkai Zasshi. 2006;44(2):111-6.
	In May 1997 he had fever, leg edema, and proteinuria, and a renal biopsy revealed secondary amyloidosis.
14724539	MALE	Middle Aged
	[Amyloidosis complicating psoriatic arthritis].
	Bergis M, Dega H, Planquois V, Benichou O, Dubertret L. Ann Dermatol Venereol. 2003;130(11):1039-42.
	The occurrence of an isolated proteinuria revealed renal and hepatic AA amyloidosis.
12058889	MALE	Middle Aged
	Amyloid a protein amyloidosis in a patient with plasma cell dyscrasia.
	Ishikawa H, Nakata K, Aritomi T, Ohkubo K, Migita K, Hamasaki K, Yamasaki S, Nakao K, Kato Y, Hayashi T, Eguchi K. Intern Med. 2002;41(5):386-91.
	We report a 59-year-old man who was found to have plasma cell dyscrasia and amyloid A protein (AA) amyloidosis during the follow-up period of chronic inactive hepatitis C. Clinical manifestations such as swallowing disturbance, proteinuria and leg edema were associated with AA amyloid deposits in his tongue and kidneys.
12384913	FEMALE	Adult
	Rapid and complete resolution of proteinuria due to renal amyloidosis in a patient with rheumatoid arthritis treated with infliximab.
	Elkayam O, Hawkins PN, Lachmann H, Yaron M, Caspi D. Arthritis Rheum. 2002;46(10):2571-3.
	We describe herein a patient with rheumatoid arthritis who developed proteinuria due to AA amyloidosis, in whom the inflammatory disease was rapidly and completely suppressed by treatment with infliximab.
11072606	MALE	Adult
	Successful treatment of protein-losing enteropathy due to AA amyloidosis with somatostatin analogue and high dose steroid in ankylosing spondylitis.
	Jeong YS, Jun JB, Kim TH, Lee IH, Bae SC, Yoo DH, Park MH, Kim SY. Clin Exp Rheumatol. 2000;18(5):619-21.
	Secondary amyloidosis is an occasional complication of ankylosing spondylitis (AS) and in most cases renal amyloidosis presents with proteinuria, nephrotic syndrome and decreased renal function.
8849359	FEMALE	Middle Aged
	Regression of the nephrotic syndrome in rheumatoid arthritis and amyloidosis treated with azathioprine. A case report.
	Shapiro DL, Spiera H. Arthritis Rheum. 1995;38(12):1851-4.
	The AA amyloidosis was documented by renal and lymph node biopsies and by the presence of proteinuria.
3761115	FEMALE	Child
	Secondary amyloidosis in Crohn's disease of childhood.
	Kirschner BS, Samowitz WS. J Pediatr Gastroenterol Nutr. 1986;5(5):816-21.
	This report describes an 11-year-old child with Crohn's disease who developed intermittent proteinuria and thyroid enlargement at 14 years of age as the initial manifestations of secondary amyloidosis.