AA amyloidosis

Secondary amyloidosis is a form of amyloidosis (see this term), that complicates chronic inflammatory disorders (mainly rheumatoid arthritis, see this term) and is characterized by the aggregation and deposition of amyloid fibrils composed of serum amyloid A protein, an acute phase reactant. Although spleen, suprarenal gland, liver and gut are frequent sites of amyloid deposition, the clinical picture is dominated by renal involvement.

Rheumatoid arthritis

Inflammatory changes in the synovial membranes and articular structures with widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, as well as atrophy and rarefaction of bony structures.


Total: 63

                      


(per page)
PMID (PMCID)
25576525
FEMALE Middle Aged
Breast pain in a patient on dialysis: a rare manifestation of calcific uraemic arteriolopathy.
Buscher K, Gabriels G, Barth P, Pavenstadt H.
BMJ Case Rep. 2015;2015:.
Her medical history included rheumatoid arthritis, AA amyloidosis and end-stage renal disease treated by peritoneal dialysis.
24959698
FEMALE
Abatacept may be effective and safe in patients with amyloid A amyloidosis secondary to rheumatoid arthritis.
Nakamura T, Kumon Y, Hirata S, Takaoka H.
Clin Exp Rheumatol. 2014;32(4):501-8.
To examine the efficacy and safety of abatacept (ABT) in patients with amyloid A (AA) amyloidosis secondary to rheumatoid arthritis (RA), and to speculate about the immunologic association of ABT with AA amyloid deposit regression.
24593212
MALE Middle Aged
Amyloid A amyloidosis in a Japanese patient with familial Mediterranean fever associated with homozygosity for the pyrin variant M694I/M694I.
Nakamura T, Migita K, Ando Y, Takaoka H, Suzushima H, Shiraishi N.
Mod Rheumatol. 2014;24(2):349-52.
His mother was also a carrier of the SAA1.3 allele, which is not only a univariate predictor of survival but also a risk factor for the association of AA amyloidosis with rheumatoid arthritis in Japanese patients, and the SAA1-13T allele in the 13T/C polymorphism on the 5'-flanking region of the SAA1 gene.
23763756
(3693877)
MALE Middle Aged
Distribution of amyloid deposits in the kidneys of a patient with reactive amyloidosis associated with rheumatoid arthritis.
Kuroda T, Tanabe N, Sato H, Nakatsue T, Wada Y, Murakami S, Nakano M, Narita I.
BMC Res Notes. 2013;6:231.
Therefore, we describe the features of reactive amyloidosis associated with rheumatoid arthritis (RA) in an autopsied patient.
23763756
(3693877)
MALE Middle Aged
Distribution of amyloid deposits in the kidneys of a patient with reactive amyloidosis associated with rheumatoid arthritis.
Kuroda T, Tanabe N, Sato H, Nakatsue T, Wada Y, Murakami S, Nakano M, Narita I.
BMC Res Notes. 2013;6:231.
Distribution of amyloid deposits in the kidneys of a patient with reactive amyloidosis associated with rheumatoid arthritis.
23767136
OTHER
[Optimized treatment of a patient having rheumatoid arthritis and gout at the same time].
Nordstrom D, Leirisalo-Repo M, Petterson T.
Duodecim. 2013;129(10):1045-8.
Biologic TNF alpha blocker medication was started for a patient having active rheumatoid arthritis, because the disease was unresponsive to conventional drugs and the patient also 'had reactive amyloidosis.
22953651
MALE Middle Aged
A case of psoriasis with secondary amyloidosis, associated symbrachydactyly of the hand and a transverse deficiency of the foot.
Balzani A, Pagnotta A, Montesi G, Gravante G, Nicoli F, Cervelli V.
Eur Rev Med Pharmacol Sci. 2012;16(7):983-5.
Secondary amyloidosis is associated with a variety of chronic inflammatory diseases such as rheumatoid arthritis, ankylosing spondylitis, familial Mediterranean fever, osteomyelitis, inflammatory bowel diseases and infective or neoplastic conditions.
22260742
FEMALE Middle Aged
Tocilizumab improves cardiac disease in a hemodialysis patient with AA amyloidosis secondary to rheumatoid arthritis.
Hattori Y, Ubara Y, Sumida K, Hiramatsu R, Hasegawa E, Yamanouchi M, Hayami N, Suwabe T, Hoshino J, Sawa N, Oohashi K, Takaichi K.
Amyloid. 2012;19(1):37-40.
Tocilizumab improves cardiac disease in a hemodialysis patient with AA amyloidosis secondary to rheumatoid arthritis.
19820941
MALE
A case with rheumatoid arthritis and systemic reactive AA amyloidosis showing rapid regression of amyloid deposition on gastroduodenal mucosa after a combined therapy of corticosteroid and etanercept.
Ishii W, Kishida D, Suzuki A, Shimojima Y, Matsuda M, Hoshii Y, Ikeda S.
Rheumatol Int. 2011;31(2):247-50.
Systemic reactive amyloid A (AA) amyloidosis is one of the critical complications associated with rheumatoid arthritis (RA).
21467708
FEMALE Middle Aged
Fatal acute pancreatitis associated with reactive AA amyloidosis in rheumatoid arthritis with end-stage renal disease: a report of three cases.
Kuroda T, Sato H, Hasegawa H, Wada Y, Murakami S, Saeki T, Nakano M, Narita I.
Intern Med. 2011;50(7):739-44.
We report three cases of fatal pancreatitis associated with systemic AA amyloidosis in rheumatoid arthritis (RA).
23126056
FEMALE Middle Aged
[Secondary (AA) renal/bone amyloidosis complicating rheumatoid arthritis].
Prkacin I, Skurla B, Pocanic D, Bulum T, Bulimbasic S, Kardum-Skelin I.
Acta Med Croatica. 2011;65 Suppl 1:217-21.
Secondary amyloidosis (AA) is a rare but serious complication that appears in the context of cancer, chronic inflammation, and chronic infectious disease, including rheumatoid arthritis.
22078699
MIXED_SAMPLE Middle Aged
[Use of etanercept in amyloidosis secondary to rheumatoid arthritis, a report of two cases].
Macias Fernandez I, Fernandez Rodriguez AM, Garcia Perez S.
Reumatol Clin. 2011;7(6):397-400.
Rheumatoid arthritis (RA) is one of the most common causes of AA amyloidosis.
20403049
FEMALE Middle Aged
AA-type amyloidosis in association with non-Hodgkin's lymphoma following CMV viremia: Autopsy case.
Tajima S, Ushijima T, Matuya S, Horiuchi H.
Pathol Int. 2010;60(3):222-7.
The serum amyloid A (SAA)1 gene polymorphism, SAA1.2/1.3, might have also been another factor in this case, considering the risk of AA amyloidosis in Japanese patients with rheumatoid arthritis.
20229259
FEMALE Middle Aged
Excellent therapeutic effect of tocilizumab on intestinal amyloid a deposition secondary to active rheumatoid arthritis.
Inoue D, Arima H, Kawanami C, Takiuchi Y, Nagano S, Kimura T, Shimoji S, Mori M, Tabata S, Yanagita S, Matsushita A, Nagai K, Imai Y, Takahashi T.
Clin Rheumatol. 2010;29(10):1195-7.
A 64-year-old woman suffering from progressive amyloid A (AA) amyloidosis of the gastrointestinal (GI) tract, associated with active rheumatoid arthritis, was transferred to our hospital due to hypovolemic shock.
20127607
FEMALE Middle Aged
[Interpretation of elevated serum troponin levels in end stage renal disease - case 2/2010].
Artunc F, Haap M, Heyne N, Weyrich P, Wolf S.
Dtsch Med Wochenschr. 2010;135(6):240.
We report on a female patient with rheumatoid arthritis and end-stage renal-disease following AA-amyloidosis who presented with chest pain to the emergency department.
20223142
MIXED_SAMPLE Middle Aged
[Secondary amyloidosis of the bladder and massive hematuria].
Garcia-Escudero Lopez A, Arruza Echevarria A, Leunda Saizar J, Infante Riano R, Padilla Nieva J, Ortiz Barredo E.
Actas Urol Esp. 2010;34(1):111-5.
Secondary amyloidosis of the bladder is of the AA type, which is more common in females and mainly secondary to rheumatoid arthritis, but also to ankylosing spondylitis and long-standing chronic inflammatory conditions.
19437089
FEMALE Adult
Tocilizumab dramatically ameliorated life-threatening diarrhea due to secondary amyloidosis associated with rheumatoid arthritis.
Sato H, Sakai T, Sugaya T, Otaki Y, Aoki K, Ishii K, Horizono H, Otani H, Abe A, Yamada N, Ishikawa H, Nakazono K, Murasawa A, Gejyo F.
Clin Rheumatol. 2009;28(9):1113-6.
Severe diarrhea improved dramatically with administration of the humanized anti-interleukin-6 receptor antibody tocilizumab (TCZ) in a patient with secondary reactive amyloidosis, which was associated with rheumatoid arthritis (RA).
19437089
FEMALE Adult
Tocilizumab dramatically ameliorated life-threatening diarrhea due to secondary amyloidosis associated with rheumatoid arthritis.
Sato H, Sakai T, Sugaya T, Otaki Y, Aoki K, Ishii K, Horizono H, Otani H, Abe A, Yamada N, Ishikawa H, Nakazono K, Murasawa A, Gejyo F.
Clin Rheumatol. 2009;28(9):1113-6.
Tocilizumab dramatically ameliorated life-threatening diarrhea due to secondary amyloidosis associated with rheumatoid arthritis.
18496698
FEMALE Middle Aged
A case of AA amyloidosis associated with rheumatoid arthritis effectively treated with Infliximab.
Kuroda T, Otaki Y, Sato H, Fujimura T, Nakatsue T, Murakami S, Sakatsume M, Nakano M, Gejyo F.
Rheumatol Int. 2008;28(11):1155-9.
We report the case of a 55-year-old Japanese woman with reactive AA amyloidosis associated with rheumatoid arthritis, in which inflammatory disease was completely suppressed with infliximab.
18496698
FEMALE Middle Aged
A case of AA amyloidosis associated with rheumatoid arthritis effectively treated with Infliximab.
Kuroda T, Otaki Y, Sato H, Fujimura T, Nakatsue T, Murakami S, Sakatsume M, Nakano M, Gejyo F.
Rheumatol Int. 2008;28(11):1155-9.
A case of AA amyloidosis associated with rheumatoid arthritis effectively treated with Infliximab.