AA amyloidosis

Secondary amyloidosis is a form of amyloidosis (see this term), that complicates chronic inflammatory disorders (mainly rheumatoid arthritis, see this term) and is characterized by the aggregation and deposition of amyloid fibrils composed of serum amyloid A protein, an acute phase reactant. Although spleen, suprarenal gland, liver and gut are frequent sites of amyloid deposition, the clinical picture is dominated by renal involvement.

Diarrhea

Abnormally increased frequency of loose or watery bowel movements.

Total: 9

(per page)

PMID (PMCID)
30333399	FEMALE	Middle Aged
	Pulmonary Mycobacterium abscessus Infection with Reactive AA Amyloidosis: A Case Report and Brief Review of the Literature.
	Torii R, Noguchi S, Shimabukuro I, Inokuchi Y, Tabaru A, Yoshii C, Yatera K. Intern Med. 2019;58(4):557-561.
	The prognosis of AA amyloidosis associated with pulmonary M. abscessus infection may be very poor, and physicians should pay attention to this rare condition when difficult-to-treat diarrhea occurs in patients with pulmonary M. abscessus infection.
30333399	FEMALE	Middle Aged
	Pulmonary Mycobacterium abscessus Infection with Reactive AA Amyloidosis: A Case Report and Brief Review of the Literature.
	Torii R, Noguchi S, Shimabukuro I, Inokuchi Y, Tabaru A, Yoshii C, Yatera K. Intern Med. 2019;58(4):557-561.
	The patient underwent gastrointestinal endoscopy for diarrhea during the treatment of pulmonary M. abscessus infection and was diagnosed with AA amyloidosis according to the histopathological findings from the endoscopic specimen.
23545677	FEMALE
	AA-amyloidosis in autosomal dominant polycystic kidney disease caused by chronic cyst infections lasting for 30 years.
	Tsuchiya Y, Ubara Y, Suwabe T, Nomura K, Sumida K, Hiramatsu R, Hoshino J, Hasegawa E, Yamanouchi M, Hayami N, Sawa N, Takaichi K, Oohashi K. Intern Med. 2013;52(7):791-4.
	If an ADPKD patient with a long history of cyst infection develops diarrhea and malaise, AA-amyloidosis should be considered as a possible complication.
20229259	FEMALE	Middle Aged
	Excellent therapeutic effect of tocilizumab on intestinal amyloid a deposition secondary to active rheumatoid arthritis.
	Inoue D, Arima H, Kawanami C, Takiuchi Y, Nagano S, Kimura T, Shimoji S, Mori M, Tabata S, Yanagita S, Matsushita A, Nagai K, Imai Y, Takahashi T. Clin Rheumatol. 2010;29(10):1195-7.
	Although intensive care, including treatment with prednisolone and methotrexate, improved the hypovolemic shock, paralytic ileus became dominant instead of the marked diarrhea, suggesting the terminal stage of AA amyloidosis of the GI tract.
19207546	FEMALE
	A rare case of multiple myeloma initially presenting with pseudoachalasia.
	Lazaraki G, Nakos A, Katodritou E, Pilpilidis I, Tarpagos A, Katsos I. Dis Esophagus. 2009;22(6):E21-4.
	Gastrointestinal manifestations in primary or secondary amyloidosis include abdominal pain, diarrhea, constipation, malabsorption, obstruction, motility disturbance, intestinal infarction, perforation, and hemorrhage; however, gastrointestinal tract involvement is asymptomatic in most instances.
19437089	FEMALE	Adult
	Tocilizumab dramatically ameliorated life-threatening diarrhea due to secondary amyloidosis associated with rheumatoid arthritis.
	Sato H, Sakai T, Sugaya T, Otaki Y, Aoki K, Ishii K, Horizono H, Otani H, Abe A, Yamada N, Ishikawa H, Nakazono K, Murasawa A, Gejyo F. Clin Rheumatol. 2009;28(9):1113-6.
	TCZ may work immediately in diarrhea associated with secondary amyloidosis.
19437089	FEMALE	Adult
	Tocilizumab dramatically ameliorated life-threatening diarrhea due to secondary amyloidosis associated with rheumatoid arthritis.
	Sato H, Sakai T, Sugaya T, Otaki Y, Aoki K, Ishii K, Horizono H, Otani H, Abe A, Yamada N, Ishikawa H, Nakazono K, Murasawa A, Gejyo F. Clin Rheumatol. 2009;28(9):1113-6.
	Severe diarrhea improved dramatically with administration of the humanized anti-interleukin-6 receptor antibody tocilizumab (TCZ) in a patient with secondary reactive amyloidosis, which was associated with rheumatoid arthritis (RA).
19437089	FEMALE	Adult
	Tocilizumab dramatically ameliorated life-threatening diarrhea due to secondary amyloidosis associated with rheumatoid arthritis.
	Sato H, Sakai T, Sugaya T, Otaki Y, Aoki K, Ishii K, Horizono H, Otani H, Abe A, Yamada N, Ishikawa H, Nakazono K, Murasawa A, Gejyo F. Clin Rheumatol. 2009;28(9):1113-6.
	Tocilizumab dramatically ameliorated life-threatening diarrhea due to secondary amyloidosis associated with rheumatoid arthritis.
16385663 (2810601)	MALE	Adult
	Association of secondary amyloidosis with common variable immune deficiency and tuberculosis.
	Celik AF, Altiparmak MR, Pamuk GE, Pamuk ON, Tabak F. Yonsei Med J. 2005;46(6):847-50.
	In this report, we discuss the association of CVID and tuberculosis to secondary amyloidosis and recurrent diarrhea.