AA amyloidosis

Secondary amyloidosis is a form of amyloidosis (see this term), that complicates chronic inflammatory disorders (mainly rheumatoid arthritis, see this term) and is characterized by the aggregation and deposition of amyloid fibrils composed of serum amyloid A protein, an acute phase reactant. Although spleen, suprarenal gland, liver and gut are frequent sites of amyloid deposition, the clinical picture is dominated by renal involvement.

Paraplegia

Severe or complete weakness of both lower extremities with sparing of the upper extremities.


Total: 3

                       


(per page)
PMID (PMCID)
22014073
 MALE Adult
Fatal gastrointestinal hemorrhage in a paraplegic man with undiagnosed AA (secondary) amyloidosis.
Baird-Howell MA, Wurzel J.
Amyloid. 2011;18(4):245-8.
Paraplegia was one of the most common causes of secondary amyloidosis decades ago, but has now become unusual in patients with AA amyloidosis.
22014073
 MALE Adult
Fatal gastrointestinal hemorrhage in a paraplegic man with undiagnosed AA (secondary) amyloidosis.
Baird-Howell MA, Wurzel J.
Amyloid. 2011;18(4):245-8.
Paraplegia was one of the most common causes of secondary amyloidosis decades ago, but has now become unusual in patients with AA amyloidosis.
11562923
 MALE Middle Aged
Secondary amyloidosis as a life-ending event in multifocal motor neuropathy.
Beydoun SR, Rison RA, Commins D.
Muscle Nerve. 2001;24(10):1396-402.
We report the first case, to our knowledge, of a patient with MMN associated with high titer of GM1 antibody who developed acute paraplegia with both cranial nerve and worsening sensory involvement associated with multiorgan compromise due to a secondary amyloidosis involving the myocardium.