AA amyloidosis

Secondary amyloidosis is a form of amyloidosis (see this term), that complicates chronic inflammatory disorders (mainly rheumatoid arthritis, see this term) and is characterized by the aggregation and deposition of amyloid fibrils composed of serum amyloid A protein, an acute phase reactant. Although spleen, suprarenal gland, liver and gut are frequent sites of amyloid deposition, the clinical picture is dominated by renal involvement.

Nephrotic range proteinuria

Severely increased amount of excretion of protein in the urine, defined as 3.5 grams per day or more in adults and 40 mg per meter-squared body surface area per hour in children.


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(per page)
PMID (PMCID)
20355355
 FEMALE Adult
Coexistence of medullary sponge kidney and renal AA amyloidosis in a patient with nephrotic range proteinuria.
Akoglu H, Dede F, Gonul II, Piskinpasa S, Odabas AR.
J Natl Med Assoc. 2010;102(3):247-9.
Coexistence of medullary sponge kidney and renal AA amyloidosis in a patient with nephrotic range proteinuria.
20969738
 FEMALE
Rapid development of renal failure secondary to AA-type amyloidosis in a patient with polymyalgia rheumatica.
Javaid MM, Kamalanathan M, Kon SP.
J Ren Care. 2010;36(4):199-202.
We present a case of a patient with history PMR who developed nephrotic range proteinuria and rapidly deteriorating renal function secondary to AA amyloidosis within 18 months of the onset of symptoms of PMR.
8042653
 MALE Middle Aged
Case report: acute renal vein thrombosis in patients with spinal cord injury and secondary amyloidosis.
Huch KM, Wall BM, Cooke CR.
Am J Med Sci. 1994;308(2):119-22.
Renal involvement with secondary amyloidosis is characterized by the presence of nephrotic range proteinuria and an increased incidence of renal vein thrombosis.