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Acute panmyelosis with myelofibrosis

Splenomegaly

Abnormal increased size of the spleen.

Total: 2

(per page)

PMID (PMCID)
21274282 (3026984)	OTHER
	Successful control of acute myelofibrosis with lenalidomide.
	Vassilopoulos G, Palassopoulou M, Zisaki K, Befani M, Bouronikou E, Giannakoulas N, Stathopoulou E, Matsouka P. Case Rep Med. 2010;2010:421239.
	Acute panmyelosis with myelofibrosis (APMF) is a rare, fatal hematological neoplasm that is characterized by the acute onset of cytopenias and fibrosis in the bone marrow in the absence of splenomegaly or fibrosis-related morphological changes in the RBCs.
6586278	MIXED_SAMPLE	Middle Aged
	Megakaryoblastic transformation in myeloproliferative disorders.
	Jacobs P, le Roux I, Jacobs L. Cancer. 1984;54(2):297-302.
	In contrast, megakaryoblastic leukemia or acute myelofibrosis, where splenomegaly and a leukoerythroblastic blood picture are typically absent, responds poorly to any form of chemotherapy, and survival is short.