Systemic sclerosis

Systemic sclerosis (SSc) is a generalized disorder of small arteries, microvessels and connective tissue, characterized by fibrosis and vascular obliteration in the skin and organs, particularly the lungs, heart, and digestive tract. There are two main subsets of SSc: diffuse cutaneous SSc (dcSSc) and limited cutaneous SSc (lcSSc) (see these terms). A third subset of SSc has also been observed, called limited Systemic Sclerosis (lSSc) or systemic sclerosis sine scleroderma (see these terms).

Splenomegaly

Abnormal increased size of the spleen.

Total: 2

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PMID (PMCID)
2377941	FEMALE	Middle Aged
	[A case of progressive systemic sclerosis associated with mutilans-type arthropathy and suspected Felty's syndrome].
	Sato T, Ozawa T, Kikuchi M, Nakano M, Gejyo F, Hanyu T, Takahashi C, Nakazono K, Murasawa A, Arakawa M. Ryumachi. 1990;30(1):53-9.
	A patient who developed mutilans-type arthropathy, splenomegaly, leukopenia, leg ulcer and massive hydroxyapatite accumulation during the course of progressive systemic sclerosis (PSS) was reported.
7114027	FEMALE	Adult
	Idiopathic portal hypertension associated with progressive systemic sclerosis.
	Umeyama K, Yui S, Fukamizu A, Yoshikawa K, Yamashita T. Am J Gastroenterol. 1982;77(9):645-8.
	Herein we describe the clinical course of a case of idiopathic portal hypertension accompanied by splenomegaly, portal hypertension, and pancytopenia in addition to progressive systemic sclerosis.