Wilson disease

Wilson disease is a very rare inherited multisystemic disease presenting non-specific neurological, hepatic, psychiatric or osseo-muscular manifestations due to excessive copper deposition in the body.

Acanthosis nigricans

A dermatosis characterized by thickened, hyperpigmented plaques, typically on the intertriginous surfaces and neck.


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PMID (PMCID)
9241968
 MALE
Acanthosis nigricans associated with hepatolenticular degeneration.
Thaipisuttikul Y.
J Dermatol. 1997;24(6):395-400.
Acanthosis nigricans and hepatolenticular degeneration (Wilson's disease) developed simultaneously in a 16-year-old boy.