Wilson disease

Wilson disease is a very rare inherited multisystemic disease presenting non-specific neurological, hepatic, psychiatric or osseo-muscular manifestations due to excessive copper deposition in the body.

Dysarthria

Dysarthric speech is a general description referring to a neurological speech disorder characterized by poor articulation. Depending on the involved neurological structures, dysarthria may be further classified as spastic, flaccid, ataxic, hyperkinetic and hypokinetic, or mixed.


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PMID (PMCID)
27915967
 FEMALE Middle Aged
Liver Transplant Can Resolve Severe Neuropsychiatric Manifestations of Wilson Disease: A Case Report.
Walker G, Hussaini T, Stowe R, Cresswell S, Yoshida EM.
Exp Clin Transplant. 2018;16(5):620-624.
The patient had severe neurologic manifestations of Wilson disease pretransplant, including dysarthria, hyperreflexia, asymmetrical ataxia, tremor, bradyphrenia, and shuffling gait.
22261259
 MIXED_SAMPLE
[Diagnosis and care of Wilson disease with neurological revelation].
Wagner S, Brunet AS, Bost M, Lachaux A, Broussolle E, Des Portes V, Lion-Francois L.
Arch Pediatr. 2012;19(3):271-6.
Neurologic symptoms are present in 35% of the patients with Wilson disease such as dystonia, extrapyramidal syndrome, dysarthria, dysphagia, and psychiatric symptoms.
1810163
 MALE
Tongue dyskinesia as an early manifestation of Wilson disease.
Liao KK, Wang SJ, Kwan SY, Kong KW, Wu ZA.
Brain Dev. 1991;13(6):451-3.
These suggested that tongue dyskinesia could be an early sign of Wilson disease and was not the main cause of his dysarthria.