Wilson disease

Wilson disease is a very rare inherited multisystemic disease presenting non-specific neurological, hepatic, psychiatric or osseo-muscular manifestations due to excessive copper deposition in the body.

Rheumatoid arthritis

Inflammatory changes in the synovial membranes and articular structures with widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, as well as atrophy and rarefaction of bony structures.


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PMID (PMCID)
16144289
 FEMALE Middle Aged
Elastosis perforans serpiginosa secondary to D-penicillamine therapy with coexisting cutis laxa.
Rosen LB, Muellenhoff M, Tran TT, Muhart M.
Cutis. 2005;76(1):49-53.
EPS has been reported in patients with Wilson disease, cystinuria, and rheumatoid arthritis after many years of high-dose therapy.