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Malonic aciduria

Malonic aciduria is a metabolic disorder caused by deficiency of malonyl-CoA decarboxylase (MCD).

Myoclonus

Very brief, involuntary random muscular contractions occurring at rest, in response to sensory stimuli, or accompanying voluntary movements.

Total: 1

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PMID (PMCID)
26167218 (4489058)	OTHER
	Valproate therapy exacerbating intermediate phenotype of methylmalonic aciduria.
	Murgai A, Deshmukh A, Puri V, Chaudhry N, Kapoor S. J Pediatr Neurosci. 2015;10(2):140-2.
	A, 11-year-old male, with delayed milestones after the age of 6 months with recurrent myoclonus and generalized tonic-clonic seizures had clinical worsening after institution of valproate, was detected to have elevated serum lactate level and marked methyl malonic aciduria.