Glucagonoma

Glucagonoma is a rare, functioning type of pancreatic neuroendocrine tumor (PNET; see this term) that hypersecretes glucagon, leading to a syndrome comprised of necrolytic migratory erythema, diabetes mellitus, anemia, weight loss, mucosal abnormalities, thromboembolism, gastrointestinal and neuropsychiatric symptoms.

Hepatosplenomegaly

Simultaneous enlargement of the liver and spleen.


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PMID (PMCID)
20499510
 FEMALE Adult
[Glucagonoma without glucagonoma syndrome].
Colovic R, Matic S, Micev M, Grubor N, Latincic S.
Srp Arh Celok Lek. 2010;138(3-4):244-7.
They usually secrete large amounts of glucagon that can cause a characteristic "glucagonoma syndrome", which includes necrolytic migratory erythema, glucose intolerance or diabetes, weight loss and sometimes, normochromic normocytic anaemia, stomatitis or cheilitis, diarrhoea or other digestive symptoms, thoromboembolism, hepatosplenomegaly, depression or other psychiatric and paraneoplastic symptoms.