Glucagonoma

Glucagonoma is a rare, functioning type of pancreatic neuroendocrine tumor (PNET; see this term) that hypersecretes glucagon, leading to a syndrome comprised of necrolytic migratory erythema, diabetes mellitus, anemia, weight loss, mucosal abnormalities, thromboembolism, gastrointestinal and neuropsychiatric symptoms.

Weight loss

Reduction inexisting body weight.


Total: 32

                       


(per page)
PMID (PMCID)
26424307
 MALE Adult
A Novel Missense Mutation of the MEN1 Gene in a Patient with Multiple Endocrine Neoplasia Type 1 with Glucagonoma and Obesity.
Murakami T, Usui T, Nakajima A, Mochida Y, Saito S, Nambu T, Kato T, Matsuda Y, Yonemitsu S, Muro S, Oki S.
Intern Med. 2015;54(19):2475-81.
However, he did not demonstrate weight loss, suggesting that the patient's obesity could have obscured the early diagnosis of a glucagonoma.
26248239
 MALE Middle Aged
Glucagonoma syndrome associated with necrolytic migratory erythema.
Cardoso Filho Fde A, Feitosa RG, Fechine CO, Matos CM, Cardoso AL, Cardoso DL.
Rev Assoc Med Bras (1992). 2015;61(3):203-6.
we report a case of glucagonoma associated necrolytic migratory erythema in a male patient, 56 years, with signs of skin lesions mainly on his legs and groin, hyperglycemia and weight loss.
23890147
 FEMALE Middle Aged
Necrolytic migratory erythema and glucagonoma rising from pancreatic head.
Tseng HC, Liu CT, Ho JC, Lin SH.
Pancreatology. 2013;13(4):455-7.
Glucagonoma syndrome encompasses necrolytic migratory erythema (NME), hyperglucagonemia, diabetes mellitus, anemia, weight loss, glossitis, angular cheilitis, steatorrhea, diarrhea, venous thrombosis, and neuropsychiatric disturbance.
23644134
 MALE Middle Aged
[Diagnosis and treatment of glucagonoma: report of one case].
Cheng H, Chen M, Yang G.
Nan Fang Yi Ke Da Xue Xue Bao. 2013;33(4):618-insidebackcover.
We report a case of glucagonoma in a 55-year-old male patient with such clinical findings of necrolytic migratory erythema, diabetes mellitus, body weight loss, and anemia.
20465606
 MALE
Glucagonoma syndrome and necrolytic migratory erythema.
Lobo I, Carvalho A, Amaral C, Machado S, Carvalho R.
Int J Dermatol. 2010;49(1):24-9.
The glucagonoma syndrome is a rare disorder, characterized by necrolytic migratory erythema, elevated serum glucagon levels, abnormal glucose tolerance, weight loss, and anemia in association with a glucagon-secreting alpha-cell tumor of the pancreas.
20499510
 FEMALE Adult
[Glucagonoma without glucagonoma syndrome].
Colovic R, Matic S, Micev M, Grubor N, Latincic S.
Srp Arh Celok Lek. 2010;138(3-4):244-7.
They usually secrete large amounts of glucagon that can cause a characteristic "glucagonoma syndrome", which includes necrolytic migratory erythema, glucose intolerance or diabetes, weight loss and sometimes, normochromic normocytic anaemia, stomatitis or cheilitis, diarrhoea or other digestive symptoms, thoromboembolism, hepatosplenomegaly, depression or other psychiatric and paraneoplastic symptoms.
17926496
 FEMALE Middle Aged
[A case of pancreatic glucagonoma].
Simonenko VB, Dulin PA, Beliaev LB, Makanin MA, Dem'ianenko AV, Zykova AA, Zhuravleva SI, Kolesnikova VN.
Klin Med (Mosk). 2007;85(8):67-70.
Glucagonoma syndrome is a disease that has an original clinical picture that includes necrolytic migrating erythema with secondary bullous dermatitis, glucose tolerance disorder or diabetes mellitus, weight loss, anemia, hypoaminoacidemia, venous thrombosis, and alimentary and mental disturbances.
15959605
 MALE Middle Aged
Rare presentation of endocrine pancreatic tumor: a case of diffuse glucagonoma without metastasis and necrolytic migratory erythema.
Chen HW, Chen HW, Su DH, Shun CT, Liu KL.
J Formos Med Assoc. 2005;104(5):363-6.
We report a case of diffuse glucagonoma necrolytic migratory erythema (NME) in a 45-year-old man with mild diabetes mellitus, mild anemia, and weight loss over 1.5 years.
16476361
 FEMALE Middle Aged
[Necrolytic migratory erythema associated with glucagonoma].
Mendoza-Guil F, Hernandez-Jurado I, Burkhardt P, Linares J, Naranjo R.
Actas Dermosifiliogr. 2005;96(3):175-8.
Glucagonoma is a rare pancreatic tumor that is usually associated with a syndrome that includes diabetes, anemia, weight loss and skin lesions in the form of necrolytic migratory erythema.
12918465
 MALE
Malignant glucagonoma of the pancreas diagnoses through anemia and diabetes mellitus.
Koike N, Hatori T, Imaizumi T, Harada N, Fukuda A, Takasaki K, Iwamoto Y.
J Hepatobiliary Pancreat Surg. 2003;10(1):101-5.
Glucagonoma of the pancreas is a rare tumor with distinct clinical manifestations, such as necrolytic migratory erythema,weight loss, anemia, diabetes mellitus, and hypoamino-acidemia.
15037834
 MALE
[Necrolytic migratory erythema revealing glucagonoma without diabetes].
Marty C, Bennet A, Bayle P, Danjoux M, Lalande T, Marguery MC, Bazex J.
Ann Med Interne (Paris). 2003;154(8):552-6.
We report a case of glucagonoma syndrome, revealed by a necrolytic migratory erythema that had developed for four Years, associated with anorexia, severe weight loss, anemia, hypoprotidemia, and hypoaminoacidemia.
11941895
 FEMALE Middle Aged
Dermatitis, glossitis, stomatitis, cheilitis, anemia and weight loss: a classic presentation of pancreatic glucagonoma.
Povoski SP, Zaman SA, Ducatman BS, McFadden DW.
W V Med J. 2002;98(1):12-4.
Dermatitis, glossitis, stomatitis, cheilitis, anemia and weight loss: a classic presentation of pancreatic glucagonoma.
12434103
 MALE
[Clinical response of an atypical glucagonoma treated with a long-acting somatostatin analog].
Bouin M, Aoust LD.
Gastroenterol Clin Biol. 2002;26(10):926-9.
We report the case of a 74-year-old patient who had a glucagonoma with particular presentation of neurological impairment and weight loss.
11836542
 FEMALE Middle Aged
Necrolytic migratory erythema associated with glucagonoma syndrome: a case report.
Dal Coleto CC, de Mello AP, Piquero-Casals J, Lima FR, Vilela MA, Festa-Neto C, Sanches JA Jr.
Rev Hosp Clin Fac Med Sao Paulo. 2001;56(6):183-8.
It usually occurs in patients with an alpha islet cell tumor of the pancreas-or glucagonoma-and when associated with glucose intolerance, anemia, hyperglucagonemia, and weight loss defines the glucagonoma syndrome.
11836542
 FEMALE Middle Aged
Necrolytic migratory erythema associated with glucagonoma syndrome: a case report.
Dal Coleto CC, de Mello AP, Piquero-Casals J, Lima FR, Vilela MA, Festa-Neto C, Sanches JA Jr.
Rev Hosp Clin Fac Med Sao Paulo. 2001;56(6):183-8.
It usually occurs in patients with an alpha islet cell tumor of the pancreas-or glucagonoma-and when associated with glucose intolerance, anemia, hyperglucagonemia, and weight loss defines the glucagonoma syndrome.
10502856
 MALE Middle Aged
Glucagonoma syndrome: a case report.
Shyr YM, Su CH, Lee CH, Wu CW, Lui WY.
Zhonghua Yi Xue Za Zhi (Taipei). 1999;62(9):639-43.
We present a case of pancreatic tail tumor with the typical glucagonoma syndrome of necrolytic migratory erythema (NME), diabetes mellitus (DM), anemia, weight loss and glossitis.
9949270
 FEMALE
Glucagonoma syndrome: survival 24 years following diagnosis.
Nightingale KJ, Davies MG, Kingsnorth AN.
Dig Surg. 1999;16(1):68-71.
The symptoms of necrolytic migratory erythema, diabetes, stomatitis, weight loss and diarrhoea represent the glucagonoma syndrome which has been recognized since the early 1970s.
10457311
 MALE Adult
Cystic glucagonoma: A rare variant of an uncommon neuroendocrine pancreas tumor.
Brown K, Kristopaitis T, Yong S, Chejfec G, Pickleman J.
J Gastrointest Surg. 1998;2(6):533-6.
We report two cases of cystic glucagonoma, one found incidentally in an asymptomatic patient and one in a patient with weight loss and diabetes but no rash.
9927793
 MALE
[Pancreatic glucagonoma and deep vein thrombosis].
Guilarte Lopez-Manas J, Bellot Garcia V, Fernandez Perez R, Caballero Plasencia A.
Gastroenterol Hepatol. 1998;21(10):483-5.
Glucagonoma is an endocrine tumor of almost exclusively pancreatic origin which is rarely associated with a clinical syndrome mainly characterized by migratory necrolytic erythema, hyperglycemia, weight loss, hypoaminoacidemia and anemia.
9201330
 MALE Adult
[Glucagonoma: case report and literature review].
das Neves MM, Martins Junior EV, Gaburri AK, Chebli JM, Stavale JN, Herani Filho AK.
Arq Gastroenterol. 1996;33(3):167-72.
Glucagonoma is a neuroendocrine tumor of pancreatic alpha cells manifested by necrolytic migratory erythema, hyperglucagonemia, glucose intolerance, weight loss, anemia and hypopaminoacidemia.