Glucagonoma

Glucagonoma is a rare, functioning type of pancreatic neuroendocrine tumor (PNET; see this term) that hypersecretes glucagon, leading to a syndrome comprised of necrolytic migratory erythema, diabetes mellitus, anemia, weight loss, mucosal abnormalities, thromboembolism, gastrointestinal and neuropsychiatric symptoms.

Hyperglycemia

An increased concentration of glucose in the blood.


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PMID (PMCID)
26248239
 MALE Middle Aged
Glucagonoma syndrome associated with necrolytic migratory erythema.
Cardoso Filho Fde A, Feitosa RG, Fechine CO, Matos CM, Cardoso AL, Cardoso DL.
Rev Assoc Med Bras (1992). 2015;61(3):203-6.
we report a case of glucagonoma associated necrolytic migratory erythema in a male patient, 56 years, with signs of skin lesions mainly on his legs and groin, hyperglycemia and weight loss.
9927793
 MALE
[Pancreatic glucagonoma and deep vein thrombosis].
Guilarte Lopez-Manas J, Bellot Garcia V, Fernandez Perez R, Caballero Plasencia A.
Gastroenterol Hepatol. 1998;21(10):483-5.
Glucagonoma is an endocrine tumor of almost exclusively pancreatic origin which is rarely associated with a clinical syndrome mainly characterized by migratory necrolytic erythema, hyperglycemia, weight loss, hypoaminoacidemia and anemia.
1435287
 MIXED_SAMPLE Adult
In vivo assessment of the metabolic alterations in glucagonoma syndrome.
Klein S, Jahoor F, Baba H, Townsend CM Jr, Shepherd M, Wolfe RR.
Metabolism. 1992;41(11):1171-5.
Stable-isotope methodology and indirect calorimetry were used to evaluate metabolic abnormalities in a patient with glucagonoma syndrome manifested by 17% body weight loss, hypoaminoacidemia, and hyperglycemia.
2836444
 FEMALE Middle Aged
[Malignant endocrine tumor of the pancreas and ensuing clinical syndromes].
Boumghar M.
J Chir (Paris). 1988;125(3):174-7.
The evolution after resection by distal pancreatectomy was remarkable for the successive occurrence of a Zollinger-Ellison syndrome which was resistant to a gastric resection, then a hyperglycemia coma with ketoacidosis and finally a glucagonoma syndrome.