Glucagonoma

Glucagonoma is a rare, functioning type of pancreatic neuroendocrine tumor (PNET; see this term) that hypersecretes glucagon, leading to a syndrome comprised of necrolytic migratory erythema, diabetes mellitus, anemia, weight loss, mucosal abnormalities, thromboembolism, gastrointestinal and neuropsychiatric symptoms.

Stomatitis

Stomatitis is an inflammation of the mucous membranes of any of the structures in the mouth.


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PMID (PMCID)
20499510
 FEMALE Adult
[Glucagonoma without glucagonoma syndrome].
Colovic R, Matic S, Micev M, Grubor N, Latincic S.
Srp Arh Celok Lek. 2010;138(3-4):244-7.
They usually secrete large amounts of glucagon that can cause a characteristic "glucagonoma syndrome", which includes necrolytic migratory erythema, glucose intolerance or diabetes, weight loss and sometimes, normochromic normocytic anaemia, stomatitis or cheilitis, diarrhoea or other digestive symptoms, thoromboembolism, hepatosplenomegaly, depression or other psychiatric and paraneoplastic symptoms.
10985071
 MALE
[Glucagon-secreting malignant neuroendocrine tumor of the pancreas].
Wickenhauser C, Aichelmann E, Neuhaus H, Holscher AH, Dienes HP.
Med Klin (Munich). 2000;95(8):466-9.
An unclear migratory erythema combined with diabetes mellitus and stomatitis/cheilosis should lead to the differential diagnosis of glucagonoma.
9949270
 FEMALE
Glucagonoma syndrome: survival 24 years following diagnosis.
Nightingale KJ, Davies MG, Kingsnorth AN.
Dig Surg. 1999;16(1):68-71.
The symptoms of necrolytic migratory erythema, diabetes, stomatitis, weight loss and diarrhoea represent the glucagonoma syndrome which has been recognized since the early 1970s.
7648942
 MALE Middle Aged
[Report of a case of glucagonoma misdiagnosed as "eczema" and "hepatic angioma" for three years and review of literature].
Dai W, Shi Y, Cai L.
Zhonghua Nei Ke Za Zhi. 1995;34(3):190-2.
Glucagonoma is a rare pancreatic tumor, necrolytic migratory erythema is its distinctive feature and it is often associated with diabetes mellitus, weight loss, anemia, hypoaminoacidemia, glossitis and stomatitis.
228832
 MALE Adult
Neurologic involvement in glucagonoma syndrome: response to combination chemotherapy with 5-fluorouracil and streptozotocin.
Khandekar JD, Oyer D, Miller HJ, Vick NA.
Cancer. 1979;44(6):2014-6.
A 34-year-old man presented with classic glucagonoma syndrome manifested by weight loss, dermatitis, stomatitis, anemia, and mild diabetes mellitus.
194536
 MIXED_SAMPLE Adult
Glucagonoma syndrome. Report of two cases and literature review.
Binnick AN, Spencer SK, Dennison WL Jr, Horton ES.
Arch Dermatol. 1977;113(6):749-54.
The glucagonoma syndrome is characterized by dermatitis, stomatitis, elevated serum glucagon levels, abnormal glucose tolerance, weight loss, and anemia--all in association with a glucagon-secreting alpha-cell tumor of the pancreas.