Glucagonoma

Glucagonoma is a rare, functioning type of pancreatic neuroendocrine tumor (PNET; see this term) that hypersecretes glucagon, leading to a syndrome comprised of necrolytic migratory erythema, diabetes mellitus, anemia, weight loss, mucosal abnormalities, thromboembolism, gastrointestinal and neuropsychiatric symptoms.

Erythema

Redness of the skin, caused by hyperemia of the capillaries in the lower layers of the skin.


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(per page)
PMID (PMCID)
28329615
 FEMALE Middle Aged
Necrolytic migratory erythema associated with fatty liver disease and the psuedoglucagonoma syndrome.
Fuller C, Glick J, Rivas S, Burris K.
Dermatol Online J. 2016;22(9):.
Although classically associated with a pancreatic glucagonoma, this patient experienced this figurate erythema in the setting of fatty liver disease with no glucagonoma.
28329615
 FEMALE Middle Aged
Necrolytic migratory erythema associated with fatty liver disease and the psuedoglucagonoma syndrome.
Fuller C, Glick J, Rivas S, Burris K.
Dermatol Online J. 2016;22(9):.
Although classically associated with a pancreatic glucagonoma, this patient experienced this figurate erythema in the setting of fatty liver disease with no glucagonoma.
20530930
 MALE Adult
A case of pancreatic glucagonoma with erythema.
Yoshida M, Hayashi K, Ohara H, Miyabe K, Okumura F, Naitoh I, Tanaka H, Ando T, Nakazawa T, Takahashi S, Joh T.
Nihon Shokakibyo Gakkai Zasshi. 2010;107(6):930-6.
A case of pancreatic glucagonoma with erythema.
19875259
 FEMALE Adult
[Dramatic efficacy of chemotherapy with 5-fluorouracil and dacarbazine in a patient with metastatic glucagonoma and cardiac insufficiency].
de Mestier L, Hammel P, Hentic O, Dove P, Levy P, Ruszniewski P.
Gastroenterol Clin Biol. 2010;34(1):106-10.
We report here an observation of a patient who was treated for a glucagonoma with multiple liver metastases, migratory necrolytic erythema, dilated cardiomypathy and diabetes that dramatically improved after a dacarbazin-based chemotherapy, allowing subsequent surgical resection of the primary.
19014744
 MALE Middle Aged
[Glucagonoma syndrome without diabetes mellitus].
Mikkelsen CS, Mikkelsen DB, Vestergaard V, Clemmensen O, Nielsen HO, Bygum A.
Ugeskr Laeger. 2008;170(47):3876.
Glucagonoma syndrome is characterized by glucagon overproduction, diabetes, depression, deep venous thrombosis and necrolytic migrating erythema.
17926496
 FEMALE Middle Aged
[A case of pancreatic glucagonoma].
Simonenko VB, Dulin PA, Beliaev LB, Makanin MA, Dem'ianenko AV, Zykova AA, Zhuravleva SI, Kolesnikova VN.
Klin Med (Mosk). 2007;85(8):67-70.
Glucagonoma syndrome is a disease that has an original clinical picture that includes necrolytic migrating erythema with secondary bullous dermatitis, glucose tolerance disorder or diabetes mellitus, weight loss, anemia, hypoaminoacidemia, venous thrombosis, and alimentary and mental disturbances.
14718149
 MALE
[Diabetes mellitus and pancreatic tumor].
Banzo J, Velilla J, Abos MD, Prats E, Razola P, Garcia F, Ubieto MA.
Rev Esp Med Nucl. 2004;23(1):33-8.
In conclusion, glucagonoma must be suspected in all diabetic patients with metastatic liver, even in absence of necrotic migratory erythema.
10985071
 MALE
[Glucagon-secreting malignant neuroendocrine tumor of the pancreas].
Wickenhauser C, Aichelmann E, Neuhaus H, Holscher AH, Dienes HP.
Med Klin (Munich). 2000;95(8):466-9.
An unclear migratory erythema combined with diabetes mellitus and stomatitis/cheilosis should lead to the differential diagnosis of glucagonoma.
9927793
 MALE
[Pancreatic glucagonoma and deep vein thrombosis].
Guilarte Lopez-Manas J, Bellot Garcia V, Fernandez Perez R, Caballero Plasencia A.
Gastroenterol Hepatol. 1998;21(10):483-5.
We report the case of a patient diagnosed with pancreatic glucagonoma the presentation of which consisted in episodes of repeated deep vein thrombosis without associated migratory necrolytic erythema.
9927793
 MALE
[Pancreatic glucagonoma and deep vein thrombosis].
Guilarte Lopez-Manas J, Bellot Garcia V, Fernandez Perez R, Caballero Plasencia A.
Gastroenterol Hepatol. 1998;21(10):483-5.
Glucagonoma is an endocrine tumor of almost exclusively pancreatic origin which is rarely associated with a clinical syndrome mainly characterized by migratory necrolytic erythema, hyperglycemia, weight loss, hypoaminoacidemia and anemia.
8729827
 MALE Adult
[Necrolytic migrating erythema without glucagonoma].
Maillard H, Celerier P, Maisonneuve C, Forest JL, Blanchi A, Pasquiou C.
Ann Dermatol Venereol. 1995;122(11-12):786-8.
The glucagonoma syndrome is an uncommon but well-known entity associating erythema necroticans migrans (ENM) with glucagonoma.
8729827
 MALE Adult
[Necrolytic migrating erythema without glucagonoma].
Maillard H, Celerier P, Maisonneuve C, Forest JL, Blanchi A, Pasquiou C.
Ann Dermatol Venereol. 1995;122(11-12):786-8.
The glucagonoma syndrome is an uncommon but well-known entity associating erythema necroticans migrans (ENM) with glucagonoma.
2865872
 FEMALE Middle Aged
Effect of somatostatin in necrolytic migratory erythema of glucagonoma.
Elsborg L, Glenthoj A.
Acta Med Scand. 1985;218(2):245-9.
The pathogenesis of necrolytic erythema in glucagonoma is discussed.
6274365
 MALE Middle Aged
[A human pancreatic glucagonoma, ultrastructural, immunocytochemical and radioimmunological investigations (author's transl)].
Voigt JJ, Hollande E, Pradayrol L, Vinel JP, Gorguet B.
Ann Pathol. 1981;1(4):287-97.
The authors report a case of glucagonoma in a 52 years old man presenting a migratory necrolytic erythema.
6245465
 MIXED_SAMPLE Adult
[Skin lesions revealing a glucagonoma (author's transl)].
Beltzer-Garelli E, Cesarini JP, Cywiner-Golenzer C, Eskenazi A, Grupper C.
Sem Hop. 1980;56(11-12):579-82.
About a case of necrolytic migratory erythema erythema revealing a malignant pancreatic glucagonoma, the authors compare the results of their study with the 25 cases published in the world.
95410
 FEMALE Middle Aged
Glucagonoma, chronic recurrent peptic ulcer disease, and enhanced amylase-creatinine clearance ratio. Report of a case with review of the literature.
Pitchumoni CS, Thelmo W, Ahmed KS, Kumar A, Davidian M, Einhorn R, Adler J, McCarthy J.
J Clin Gastroenterol. 1979;1(3):219-23.
A 53-year-old white woman developed diabetes mellitus, migratory erythema, and anemia, clinical features suggesting the presence of a "glucagonoma."
194305
 MIXED_SAMPLE Infant
[Pancreatic island cell tumors and their syndromes. I. Insulinomas, organic hypertinsulinism].
Woodtli W, Hedinger C.
Schweiz Med Wochenschr. 1977;107(20):685-93.
The third patient fell ill with erythema and other symptoms known from the "glucagonoma syndrome".