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Glucagonoma

Glucagonoma is a rare, functioning type of pancreatic neuroendocrine tumor (PNET; see this term) that hypersecretes glucagon, leading to a syndrome comprised of necrolytic migratory erythema, diabetes mellitus, anemia, weight loss, mucosal abnormalities, thromboembolism, gastrointestinal and neuropsychiatric symptoms.

Necrolytic migratory erythema

Acral or periorificial lesions that evolve in recurrent crops, with an annular and migratory distribution.

Total: 109

(per page)

PMID (PMCID)
30124507	FEMALE	Adult
	Glucagonoma-Associated Necrolytic Migratory Erythema: The Broad Spectrum of the Clinical and Histopathological Findings and Clues to the Diagnosis.
	Toberer F, Hartschuh W, Wiedemeyer K. Am J Dermatopathol. 2019;41(3):e29-e32.
	Glucagonoma-Associated Necrolytic Migratory Erythema: The Broad Spectrum of the Clinical and Histopathological Findings and Clues to the Diagnosis.
29450880	FEMALE	Middle Aged
	A review of cutaneous manifestations within glucagonoma syndrome: necrolytic migratory erythema.
	Tolliver S, Graham J, Kaffenberger BH. Int J Dermatol. 2018;57(6):642-645.
	A review of cutaneous manifestations within glucagonoma syndrome: necrolytic migratory erythema.
29450880	FEMALE	Middle Aged
	A review of cutaneous manifestations within glucagonoma syndrome: necrolytic migratory erythema.
	Tolliver S, Graham J, Kaffenberger BH. Int J Dermatol. 2018;57(6):642-645.
	Necrolytic migratory erythema (NME) is a rare skin disorder that is a cutaneous manifestation of the glucagonoma syndrome.
29450880	FEMALE	Middle Aged
	A review of cutaneous manifestations within glucagonoma syndrome: necrolytic migratory erythema.
	Tolliver S, Graham J, Kaffenberger BH. Int J Dermatol. 2018;57(6):642-645.
	Clinical examination and biopsy were consistent with necrolytic migratory erythema due to an underlying glucagonoma.
29688432	FEMALE	Middle Aged
	Glucagonoma With Necrolytic Migratory Erythema: Metabolic Profile and Detection of Biallelic Inactivation of DAXX Gene.
	Tamura A, Ogasawara T, Fujii Y, Kaneko H, Nakayama A, Higuchi S, Hashimoto N, Miyabayashi Y, Fujimoto M, Komai E, Kono T, Sakuma I, Nagano H, Suzuki S, Koide H, Yokote K, Iseki K, Oguma R, Matsue H, Nojima H, Sugiura K, Yoshitomi H, Ohtsuka M, Rahmutulla B, Kaneda A, Inoshita N, Ogawa S, Tanaka T. J Clin Endocrinol Metab. 2018;103(7):2417-2423.
	Glucagonoma With Necrolytic Migratory Erythema: Metabolic Profile and Detection of Biallelic Inactivation of DAXX Gene.
30665484	FEMALE	Middle Aged
	Necrolytic Migratory Erythema: Complete Healing after Surgical Removal of Pancreatic Carcinoma.
	V'lckova-Laskoska M, Balabanova-Stefanova M, Arsovska-Bezhoska I, Caca-Biljanovska N, Laskoski D. Acta Dermatovenerol Croat. 2018;26(4):329-332.
	Although necrolytic migratory erythema is a specific finding in glucagonoma syndrome, it may occur in other settings, unassociated with an alpha-cell pancreatic tumor (pseudoglucagonoma syndrome).
30665484	FEMALE	Middle Aged
	Necrolytic Migratory Erythema: Complete Healing after Surgical Removal of Pancreatic Carcinoma.
	V'lckova-Laskoska M, Balabanova-Stefanova M, Arsovska-Bezhoska I, Caca-Biljanovska N, Laskoski D. Acta Dermatovenerol Croat. 2018;26(4):329-332.
	Necrolytic migratory erythema is considered an obligatory cutaneous paraneoplastic sign associated with glucagonoma.
30665484	FEMALE	Middle Aged
	Necrolytic Migratory Erythema: Complete Healing after Surgical Removal of Pancreatic Carcinoma.
	V'lckova-Laskoska M, Balabanova-Stefanova M, Arsovska-Bezhoska I, Caca-Biljanovska N, Laskoski D. Acta Dermatovenerol Croat. 2018;26(4):329-332.
	Glucagonoma syndrome is defined by the presence of an alpha-cell secreting tumor of the pancreas, elevated levels of glucagon, and a characteristic rash called necrolytic migratory erythema.
30665484	FEMALE	Middle Aged
	Necrolytic Migratory Erythema: Complete Healing after Surgical Removal of Pancreatic Carcinoma.
	V'lckova-Laskoska M, Balabanova-Stefanova M, Arsovska-Bezhoska I, Caca-Biljanovska N, Laskoski D. Acta Dermatovenerol Croat. 2018;26(4):329-332.
	Appropriate awareness of the characteristics of necrolytic migratory erythema in physicians/dermatologists often leads to an early diagnosis of glucagonoma syndrome and enhances the chances of a favorable outcome.
28329615	FEMALE	Middle Aged
	Necrolytic migratory erythema associated with fatty liver disease and the psuedoglucagonoma syndrome.
	Fuller C, Glick J, Rivas S, Burris K. Dermatol Online J. 2016;22(9):.
	The rarity of pseudoglucagonoma syndrome, or necrolytic migratory erythema occurring in the absence of a glucagonoma, warranted the discussion of this case.
26585841	OTHER
	Paediatric necrolytic migratory erythema as a presenting sign of glucagonoma syndrome.
	Luber AJ, Ackerman LS, Culpepper KS, Buschmann CM, Koep LJ. Br J Dermatol. 2016;174(5):1092-1095.
	Glucagonoma syndrome is an extremely rare pancreatic neuroendocrine tumour often associated with necrolytic migratory erythema.
26585841	OTHER
	Paediatric necrolytic migratory erythema as a presenting sign of glucagonoma syndrome.
	Luber AJ, Ackerman LS, Culpepper KS, Buschmann CM, Koep LJ. Br J Dermatol. 2016;174(5):1092-1095.
	Detection of the cutaneous rash of necrolytic migratory erythema can aid in the early diagnosis of a glucagonoma, as well as the prevention of metastatic disease.
26585841	OTHER
	Paediatric necrolytic migratory erythema as a presenting sign of glucagonoma syndrome.
	Luber AJ, Ackerman LS, Culpepper KS, Buschmann CM, Koep LJ. Br J Dermatol. 2016;174(5):1092-1095.
	We present the case of a 15-year-old girl with a 4-year history of a rash, consistent with necrolytic migratory erythema, found to have a localized glucagonoma.
26248239	MALE	Middle Aged
	Glucagonoma syndrome associated with necrolytic migratory erythema.
	Cardoso Filho Fde A, Feitosa RG, Fechine CO, Matos CM, Cardoso AL, Cardoso DL. Rev Assoc Med Bras (1992). 2015;61(3):203-6.
	we report a case of glucagonoma associated necrolytic migratory erythema in a male patient, 56 years, with signs of skin lesions mainly on his legs and groin, hyperglycemia and weight loss.
26248239	MALE	Middle Aged
	Glucagonoma syndrome associated with necrolytic migratory erythema.
	Cardoso Filho Fde A, Feitosa RG, Fechine CO, Matos CM, Cardoso AL, Cardoso DL. Rev Assoc Med Bras (1992). 2015;61(3):203-6.
	the necrolytic migratory erythema is important for the clinical recognition of glucagonoma, and its early diagnosis is essential for a successful curative therapy.
23279825	FEMALE	Adult
	Necrolytic migratory erythema associated with glucagonoma syndrome diagnosed by ⁶⁸Ga-DOTANOC PET-CT.
	Sahoo MK, Gupta S, Singh I, Pahwa S, Durgapal P, Bal CS. Asia Pac J Clin Oncol. 2014;10(2):190-3.
	Necrolytic migratory erythema associated with glucagonoma syndrome diagnosed by 83108312Ga-DOTANOC PET-CT.
26183746	FEMALE	Middle Aged
	Rapid improvement of glucagonoma-related necrolytic migratory erythema with octreotide.
	Kimbara S, Fujiwara Y, Toyoda M, Chayahara N, Imamura Y, Kiyota N, Mukohara T, Fukunaga A, Oka M, Nishigori C, Minami H. Clin J Gastroenterol. 2014;7(3):255-9.
	Rapid improvement of glucagonoma-related necrolytic migratory erythema with octreotide.
23738981	MALE
	Necrolytic migratory erythema associated with a glucagon-producing primary hepatic neuroendocrine carcinoma in a cat.
	Asakawa MG, Cullen JM, Linder KE. Vet Dermatol. 2013;24(4):466-9, e109-10.
	In humans, necrolytic migratory erythema (NME) is a syndrome with a characteristic skin rash that is associated most often with a pancreatic glucagonoma and is recognized as part of the glucagonoma syndrome.
23738981	MALE
	Necrolytic migratory erythema associated with a glucagon-producing primary hepatic neuroendocrine carcinoma in a cat.
	Asakawa MG, Cullen JM, Linder KE. Vet Dermatol. 2013;24(4):466-9, e109-10.
	In humans, necrolytic migratory erythema (NME) is a syndrome with a characteristic skin rash that is associated most often with a pancreatic glucagonoma and is recognized as part of the glucagonoma syndrome.
24018597	FEMALE	Middle Aged
	Pancreatic glucagonoma metastasising to the right ovary five years after initial surgery: a case report.
	Watt DG, Pandanaboyana S, Herrington CS, Tait IS. JOP. 2013;14(5):510-4.
	The authors present a case of a glucagonoma that initially presented with classical necrolytic migratory erythema and a large solitary mass in the body and tail of the pancreas that was surgically resected.