Name: PubCaseFinder
License: http://creativecommons.org/licenses/by/2.1/jp/
Keywords: PubCaseFinder,PCF,Rare Disease,Phenotype,Gene,Match,Assist

Glucagonoma

Glucagonoma is a rare, functioning type of pancreatic neuroendocrine tumor (PNET; see this term) that hypersecretes glucagon, leading to a syndrome comprised of necrolytic migratory erythema, diabetes mellitus, anemia, weight loss, mucosal abnormalities, thromboembolism, gastrointestinal and neuropsychiatric symptoms.

Acantholysis

The loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes.

Total: 1

(per page)

PMID (PMCID)
8252773	MALE
	Suprabasal acantholysis--an unusual feature of necrolytic migratory erythema.
	Long CC, Laidler P, Holt PJ. Clin Exp Dermatol. 1993;18(5):464-7.
	Glucagonoma syndrome should be considered in patients with diabetes, weight loss and anaemia who present with a scaling rash, the histology of which shows suprabasal acantholysis.