VIPoma

VIPoma is an extremely rare type of pancreatic neuroendocrine tumor (see this term) that secretes vasoactive intestinal polypeptide (VIP) leading to the manifestations of watery diarrhea, hypokalemia and achlorhydia or hypochhlorhydia (known as WDHA syndrome).

Secretory diarrhea

Watery voluminous diarrhea resulting from an imbalance between ion and water secretion and absorption.


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PMID (PMCID)
15455292
 MALE Infant
[The VIP-secreting tumor as a differential diagnosis of protracted diarrhea in pediatrics].
Reindl T, Degenhardt P, Luck W, Riebel T, Sarioglu N, Henze G, Driever PH.
Klin Padiatr. 2004;216(5):264-9.
In case of prolonged therapy-resistant secretory diarrhea the existence of a VIP-secreting tumor should be considered.
14523904
 FEMALE
[Acute renal failure caused by VIP-secreting tumor].
Lambertini D, Bottini E, Talassi E, Tarchini R, Gaetti L, Bellomi A.
G Ital Nefrol. 2003;20(4):419-22.
Diagnosis requires the documentation of large volumes of secretory diarrhea, elevated VIP plasma levels, and the localization of the VIP-secreting tumor.
2862821
 FEMALE
Pancreatic cholera syndrome: effect of a synthetic somatostatin analog on intestinal water and ion transport.
Santangelo WC, O'Dorisio TM, Kim JG, Severino G, Krejs GJ.
Ann Intern Med. 1985;103(3):363-7.
The effect of a synthetic somatostatin analog was studied in a patient with severe secretory diarrhea due to pancreatic cholera syndrome.
6095478
 MIXED_SAMPLE Adult
Secretory diarrhea with islet cell hyperplasia and increased immunohistochemical reactivity to serotonin.
Nishiyama RH, Thompson NW, Lloyd R, Augur NA.
Surgery. 1984;96(6):1038-44.
Two patients with secretory diarrhea and signs and symptoms consistent with the Verner-Morrison syndrome and islet cell hyperplasia are described.