Refractory anemia

Refractory cytopenias with unilineage dysplasia (RCUD) is a frequent low-risk subtype of myelodysplastic syndrome (MDS; see this term) characterized by refractory cytopenias associated with dysplasia limited to one cell lineage.

Thrombocytopenia

A reduction in the number of circulating thrombocytes.


Total: 16

                       


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PMID (PMCID)
18829109
 MALE Adult
Unbalanced whole-arm translocation der(5;19)(p10;q10) is a novel and recurrent cytogenetic aberration in myelodysplastic syndrome.
Yamamoto K, Okamura A, Katayama Y, Shimoyama M, Matsui T.
Leuk Res. 2009;33(3):377-83.
Furthermore, these patients presented several common clinical and hematological characteristics: MDS subtypes as refractory anemia with excess of blasts (RAEB)-1 or RAEB-2, marked anemia and thrombocytopenia without neutropenia, leukoerythroblastosis, trilineage dysplasia with prominent dyserythropoiesis, CD7 expression in blasts, and association with abnormalities of chromosomes 6, 17 and 18.
15806514
 MIXED_SAMPLE
The faces of mast cell disease: bone marrow infiltrates in 3 patients with systemic mastocytosis.
Martinez AE, Medina AM, Hyde JA, Krill-Jackson E, Blaustein A, Schwartz M, Cabello-Inchausti B.
Ann Diagn Pathol. 2005;9(2):81-5.
Herein, 3 cases are presented to illustrate the clinical and morphologic heterogeneity of mast cell disease: the first patient, with long standing urticaria pigmentosa, developed anemia and thrombocytopenia; the second patient presented with a pathologic fracture; and the third patient was suspected to have refractory anemia.
15815885
 MALE
Partial splenic embolization in myelodysplastic syndrome associated with immune thrombocytopenia.
Ozdogu H, Boga C, Oguzkurt L, Kizilkilic E.
J Thromb Thrombolysis. 2004;18(3):213-6.
In addition to MDS with refractory anemia, there were management difficulties related to severe thrombocytopenia after alloimmunization from multiple blood transfusions.
15199747
 FEMALE Adult
[Successful corticosteroid treatment of thrombocytopenia in a pregnant woman with myelodysplastic syndrome (refractory anemia)].
Murase K, Matsunaga T, Takimoto R, Takahira N, Fujimi A, Takeuchi N, Terui T, Niitsu Y.
Rinsho Ketsueki. 2004;45(5):383-6.
[Successful corticosteroid treatment of thrombocytopenia in a pregnant woman with myelodysplastic syndrome (refractory anemia)].
11578269
 MALE
Investigation of coronary artery bypass grafting for a patient with myelodysplastic syndrome.
Miyagi Y, Yamauchi S, Suzuki S, Kitagawa A, Masaki Y, Gomibuchi M, Tanaka S.
Ann Thorac Cardiovasc Surg. 2001;7(4):250-3.
MDS causes refractory anemia accompanied by various degrees of granulocytopenia and thrombocytopenia.
11688831
 FEMALE
Myelodysplastic syndrome accompanied by Addison's disease and multiple autoimmune phenomena: steroid therapy resolved cytopenias and all immune disorders.
Funato K, Kuriyama Y, Uchida Y, Suzuki A, Miyazawa K, Ohyashiki K.
Intern Med. 2001;40(10):1041-4.
An 82-year-old woman with refractory anemia (RA) rapidly developed thrombocytopenia with the appearance of symptoms such as purpura, fatigue, anorexia, and weight loss.
11074541
 MALE
Epstein-Barr virus associated B-cell lymphoma of brain developing in myelodysplastic syndrome with c-kit mutation (Try-557 -->stop).
Kuwahara Y, Hirata A, Miwa H, Munakata S, Ueda S, Kanakura Y, Maruno M, Hongyo T, Nomura T, Aozasa K.
Am J Hematol. 2000;65(3):234-8.
A 68-year-old man was admitted because of anemia, fever, and thrombocytopenia and was diagnosed as having MDS (refractory anemia with excess of blasts) on the basis of the findings of bone marrow aspiration and chromosomal analysis.
10911385
 FEMALE Middle Aged
Prolonged complete remission of myelodysplastic syndrome treated with danazol, retinoic acid and low-dose prednisone.
Sadek I, Zayed E, Hayne O, Fernandez L.
Am J Hematol. 2000;64(4):306-10.
This report indicates that restoration of normal hematopoiesis, prolongation of disease-free survival, and delay in the transformation to acute leukemia may be achieved by this combination of treatment in a subset of patients with MDS, especially refractory anemia with severe thrombocytopenia.
10509005
 MIXED_SAMPLE Middle Aged
Clinical analysis and TPO levels in three patients with refractory thrombocytopenia.
Kyoda K, Nakamura S, Takeshima M, Okumura H, Ohtake S, Matsuda T, Miyakoshi H.
Am J Hematol. 1999;62(2):103-5.
Refractory thrombocytopenia (RTC) is a counter-concept to refractory anemia, which is characterized by isolated thrombocytopenia associated with clonal chromosomal abnormality.
10509005
 MIXED_SAMPLE Middle Aged
Clinical analysis and TPO levels in three patients with refractory thrombocytopenia.
Kyoda K, Nakamura S, Takeshima M, Okumura H, Ohtake S, Matsuda T, Miyakoshi H.
Am J Hematol. 1999;62(2):103-5.
Refractory thrombocytopenia (RTC) is a counter-concept to refractory anemia, which is characterized by isolated thrombocytopenia associated with clonal chromosomal abnormality.
9874184
 MIXED_SAMPLE Adult
Acute leukemia following treatment of malignant glioma.
Perry JR, Brown MT, Gockerman JP.
J Neurooncol. 1998;40(1):39-46.
Progressive macrocytosis, early dose reductions for thrombocytopenia, and refractory anemia may provide early diagnostic clues.
8774620
 MALE Middle Aged
Refractory thrombocytopenia with chromosome 11q23 abnormality.
Imoto S, Hayashi Y, Matsui T, Murayama T, Iwata N, Matsuoka H, Nagata A, Itoh H, Chihara K.
Ann Hematol. 1996;73(2):99-102.
The term "refractory thrombocytopenia" (RTC) has been proposed as a counterpart of refractory anemia.
8148416
 MIXED_SAMPLE Middle Aged
Chronic neutrophilic leukemia. A study of four cases.
Zittoun R, Rea D, Ngoc LH, Ramond S.
Ann Hematol. 1994;68(2):55-60.
The last patient presented combined features of CNL and refractory anemia with excess of blasts, and was characterized by both progressive leukocytosis and severe thrombocytopenia; acute transformation into acute myelogenous leukemia occurred 6 months after diagnosis and death 1 month later.
7871959
 MALE Infant
Myelofibrosis in severe combined immunodeficiency due to vitamin D deficiency rickets.
al-Eissa YA, al-Mashhadani SA.
Acta Haematol. 1994;92(3):160-3.
An infant with severe combined immunodeficiency is described in whom a refractory anemia and thrombocytopenia developed after the age of 6 months, associated with poor growth and frequent episodes of upper respiratory tract infections and diarrhea.
1354434
 FEMALE Infant, Newborn
Pregnancy in aplastic anemia treated with fetal liver and bone marrow hemopoietic cells and antithymocyte globulin.
Pajor A, Janossa M, Kelemen E.
Arch Gynecol Obstet. 1992;251(4):207-10.
This report describes a patient who had severe refractory anemia and thrombocytopenia during her first pregnancy.
7056685
 OTHER
Myelomonocytic myeloproliferative diseases in a horse.
Brumbaugh GW, Stitzel KA, Zinkl JG, Feldman BF.
J Am Vet Med Assoc. 1982;180(3):313-6.
Hematologic findings included severe refractory anemia, thrombocytopenia, monocytosis, and pleomorphic leukocytes, with a left shift of the myeloid series.