Refractory anemia

Refractory cytopenias with unilineage dysplasia (RCUD) is a frequent low-risk subtype of myelodysplastic syndrome (MDS; see this term) characterized by refractory cytopenias associated with dysplasia limited to one cell lineage.

Anemia

A reduction in erythrocytes volume or hemoglobin concentration.


Total: 10

                       


(per page)
PMID (PMCID)
29129340
 MALE Middle Aged
Synchronous colorectal cancer and multiple myeloma with chest wall involvement: Is this a coincidence?
Li QL, Ma JA, Li HP, Huang RB, Hu CH, Liu XL, Gao YW, Feng GH, Wu F.
Curr Probl Cancer. 2017;41(6):413-418.
Therefore, when CRC is associated with refractory anemia, we should not only assume that anemia is a classical symptom of CRC, a result of chronic blood loss, nutritional deficiencies, or myelosuppression due to chemotherapy, but we should also consider that it may reflect the possibility of a coexisting hematologic malignancy.
19668557
(2709018)
 OTHER
Nonarteritic anterior ischemic optic neuropathy associated with chronic anemia: a case series of myelodysplastic syndrome patients.
Brouzas D, Charakidas A, Ladas I, Apostolopoulos M.
Clin Ophthalmol. 2009;3:133-7.
Chronic anemia, as presented in myelodysplastic syndrome's refractory anemia subtype, probably in the presence of additional factors, such as hypotension, is likely to be complicated by optic neuropathy, possibly through a mechanism of anemic hypoxia and/or microvascular insufficiency.
18829109
 MALE Adult
Unbalanced whole-arm translocation der(5;19)(p10;q10) is a novel and recurrent cytogenetic aberration in myelodysplastic syndrome.
Yamamoto K, Okamura A, Katayama Y, Shimoyama M, Matsui T.
Leuk Res. 2009;33(3):377-83.
Furthermore, these patients presented several common clinical and hematological characteristics: MDS subtypes as refractory anemia with excess of blasts (RAEB)-1 or RAEB-2, marked anemia and thrombocytopenia without neutropenia, leukoerythroblastosis, trilineage dysplasia with prominent dyserythropoiesis, CD7 expression in blasts, and association with abnormalities of chromosomes 6, 17 and 18.
16838325
 FEMALE
Transcriptosome and serum cytokine profiling of an atypical case of myelodysplastic syndrome with progression to acute myelogenous leukemia.
Mahadevan D, DiMento J, Croce KD, Riley C, George B, Fuchs D, Mathews T, Wilson C, Lobell M.
Am J Hematol. 2006;81(10):779-86.
A Native American-Indian female presenting with anemia and thrombocytosis was diagnosed with myelodysplastic syndrome (MDS, refractory anemia).
15806514
 MIXED_SAMPLE
The faces of mast cell disease: bone marrow infiltrates in 3 patients with systemic mastocytosis.
Martinez AE, Medina AM, Hyde JA, Krill-Jackson E, Blaustein A, Schwartz M, Cabello-Inchausti B.
Ann Diagn Pathol. 2005;9(2):81-5.
Herein, 3 cases are presented to illustrate the clinical and morphologic heterogeneity of mast cell disease: the first patient, with long standing urticaria pigmentosa, developed anemia and thrombocytopenia; the second patient presented with a pathologic fracture; and the third patient was suspected to have refractory anemia.
15160971
 MALE Child
Marked thrombocytosis in a child with advanced myelodysplastic syndrome.
Claviez A, Ngoumou B, Harder L, Baumann I, Niemeyer C.
Leuk Lymphoma. 2004;45(4):849-50.
We describe the case of an 1-year-old boy with advanced MDS, specifically refractory anemia with excess of blasts who presented with leukocytopenia and anemia but marked thrombocytosis at diagnosis.
15199747
 FEMALE Adult
[Successful corticosteroid treatment of thrombocytopenia in a pregnant woman with myelodysplastic syndrome (refractory anemia)].
Murase K, Matsunaga T, Takimoto R, Takahira N, Fujimi A, Takeuchi N, Terui T, Niitsu Y.
Rinsho Ketsueki. 2004;45(5):383-6.
A 31-year-old pregnant woman was referred to our hospital due to anemia and thrombocytopenia, and was diagnosed as having myelodysplastic syndrome (refractory anemia) with autoimmune thrombocytopenia.
11793099
 FEMALE Infant
Glomerular involvement in myelodysplastic syndromes.
Bogdanovic R, Kuzmanovic M, Markovic-Lipkovski J, Ognjanovic M, Micic D, Stankovic I, Stajic N, Nikolic V, Bunjevacki G.
Pediatr Nephrol. 2001;16(12):1053-7.
Patient 2, who had refractory anemia with clonal monosomy 19, presented with bowel disease, hepatosplenomegaly, anemia and non-organ-specific autoantibodies.
11074541
 MALE
Epstein-Barr virus associated B-cell lymphoma of brain developing in myelodysplastic syndrome with c-kit mutation (Try-557 -->stop).
Kuwahara Y, Hirata A, Miwa H, Munakata S, Ueda S, Kanakura Y, Maruno M, Hongyo T, Nomura T, Aozasa K.
Am J Hematol. 2000;65(3):234-8.
A 68-year-old man was admitted because of anemia, fever, and thrombocytopenia and was diagnosed as having MDS (refractory anemia with excess of blasts) on the basis of the findings of bone marrow aspiration and chromosomal analysis.
9128421
 FEMALE Middle Aged
[A case of malignant rheumatoid arthritis associated with myelodysplastic syndrome].
Hisakawa N, Nishiya K, Hashimoto K, Tanaka Y.
Ryumachi. 1997;37(1):30-5.
The patient (57 year-old female) complained of high fever and polyarthralgia in autumn of 1994, when a diagnosis of refractory anemia, a type of myelodysplastic syndrome (MDS) was made by severe anemia (RBC: 154 x 10(4)/microliters), leucopenia (2,200/microliters) and erythroid hyperplasia, ring-nucleated myelocyte, micromegakaryocyte and less than 5% of blasts in bone marrow smear.