Refractory anemia

Refractory cytopenias with unilineage dysplasia (RCUD) is a frequent low-risk subtype of myelodysplastic syndrome (MDS; see this term) characterized by refractory cytopenias associated with dysplasia limited to one cell lineage.

Leukocytosis

An abnormal increase in the number of leukocytes in the blood.


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PMID (PMCID)
9364865
 FEMALE Adult
[Myelodysplastic syndrome with monosomy 7 following combination therapy with granulocyte colony-stimulating factor, cyclosporin A and danazole in an adult patient with severe aplastic anemia].
Tsuzuki M, Okamoto M, Yamaguchi T, Ino T, Ezaki K, Hirano M.
Rinsho Ketsueki. 1997;38(9):745-51.
Eight months after initial treatment, leukocytosis and reticulocytosis were observed and bone marrow aspirate showed hypercellular marrow with morphological and cytogenetic features (45, XX, -7 [16]/46, XX [4]) characteristic of MDS (refractory anemia).
8148416
 MIXED_SAMPLE Middle Aged
Chronic neutrophilic leukemia. A study of four cases.
Zittoun R, Rea D, Ngoc LH, Ramond S.
Ann Hematol. 1994;68(2):55-60.
The last patient presented combined features of CNL and refractory anemia with excess of blasts, and was characterized by both progressive leukocytosis and severe thrombocytopenia; acute transformation into acute myelogenous leukemia occurred 6 months after diagnosis and death 1 month later.