Refractory anemia

Refractory cytopenias with unilineage dysplasia (RCUD) is a frequent low-risk subtype of myelodysplastic syndrome (MDS; see this term) characterized by refractory cytopenias associated with dysplasia limited to one cell lineage.

Acute leukemia

A clonal (malignant) hematopoietic disorder with an acute onset, affecting the bone marrow and the peripheral blood. The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts).

Total: 6

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PMID (PMCID)
10911385	FEMALE	Middle Aged
	Prolonged complete remission of myelodysplastic syndrome treated with danazol, retinoic acid and low-dose prednisone.
	Sadek I, Zayed E, Hayne O, Fernandez L. Am J Hematol. 2000;64(4):306-10.
	This report indicates that restoration of normal hematopoiesis, prolongation of disease-free survival, and delay in the transformation to acute leukemia may be achieved by this combination of treatment in a subset of patients with MDS, especially refractory anemia with severe thrombocytopenia.
8683868	MALE
	[Two cases of therapy-related myelodysplastic syndrome].
	Takahashi A, Nagoshi H, Yamakawa T, Fukumura R, Matsuoka R, Nomura M, Takahashi S, Isobe H, Ide K, Saito N. Rinsho Ketsueki. 1996;37(1):53-9.
	Two cases of secondary MDS progressed refractory anemia with excess of blasts (RAEB), however two of 14 patients with primary MDS progressed to acute leukemia.
8402552	FEMALE	Middle Aged
	Trisomy 13 in a patient with leukemic progression of myelodysplasia.
	Luciano L, Polito P, Catalano L, Selleri C, Alfinito F, Rotoli B. Cancer Genet Cytogenet. 1993;69(2):136-8.
	Four months after the diagnosis of refractory anemia, a 60-year-old patient developed acute leukemia with blast cells that were poorly differentiated by morphology and clearly myeloid by immunophenotyping.
3946411	MIXED_SAMPLE	Adult
	Nuclear bridging of erythroblasts in acquired dyserythropoiesis: an early and transient preleukemic marker.
	Bethlenfalvay NC, Phaure TA, Phyliky RL, Bowman RP. Am J Hematol. 1986;21(3):315-22.
	The clinical, hematologic, and histological characteristics of two patients who progressed from refractory anemia to acute leukemia are described.
717391	FEMALE	Middle Aged
	Association of 5q- and refractory anemia.
	Kaffe S, Hsu LY, Hoffman R, Hirschhorn K. Am J Hematol. 1978;4(3):269-72.
	It remains to be seen whether patients with refractory anemia and 5q- tend to develop acute leukemia, as has been recently suggested.
272208	MALE	Middle Aged
	Conversion of polycythemia vera to refractory anemia with hyperplastic bone marrow.
	Mitrou PS, Fischer M, Krehan L, Martin H. Blut. 1978;36(1):41-5.
	The prognosis in cases of refractory anemia with hyperplastic bone marrow following polycythemia vera is, independent of the subsequent acute leukemia, invariably terminal.