Refractory anemia

Refractory cytopenias with unilineage dysplasia (RCUD) is a frequent low-risk subtype of myelodysplastic syndrome (MDS; see this term) characterized by refractory cytopenias associated with dysplasia limited to one cell lineage.

Myelodysplasia

Clonal hematopoietic stem cell disorders characterized by dysplasia (ineffective production) in one or more hematopoietic cell lineages, leading to anemia and cytopenia.


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PMID (PMCID)
11226524
 FEMALE
Talc induced transfusion independence in a patient with myelodysplasia.
Hirawat S, Arunabh A, Schulman P.
Leuk Res. 2001;25(3):263-5.
Myelodysplasia with refractory anemia is associated with transfusion dependence.
10390890
 MALE
[Marked hematologic improvement despite deterioration of marrow cell dysplasia in a refractory anemia patient treated with vitamin D3].
Wakimoto N, Kimura F, Sato K, Kuwada N, Matsumura T, Yamashita T, Nakamura Y, Yoshida M, Nakamura Y, Motoyoshi K.
Rinsho Ketsueki. 1999;40(5):408-13.
He was given a diagnosis of refractory anemia on the basis of bone marrow aspiration findings, which disclosed trilineage myelodysplasia.
9389371
 FEMALE Middle Aged
Sequential development of myelodysplasia and acute myeloid leukemia but with no karyotypic evolution after autografting in a patient with Philadelphia positive acute lymphoblastic leukemia.
Saso R, Zomas A, Hamblin M, Dunlop L, Swansbury GJ, Min T, Singhal S, Powles R, Treleaven J, Mehta J.
Leuk Lymphoma. 1997;26(5-6):625-8.
Moderate pancytopenia developed after 4 months, and myelodysplasia (refractory anemia) was diagnosed which rapidly evolved into AML.
8689605
 MIXED_SAMPLE Child
Trisomy 15 in hematological malignancies: six cases and review of the literature.
Smith SR, Rowe D.
Cancer Genet Cytogenet. 1996;89(1):27-30.
Four patients had myelodysplasia (refractory anemia), one patient each had acute myeloid leukemia and acute lymphoblastic leukemia.
8560614
 FEMALE
Bernard-Soulier-like functional platelet defect in myelodysplastic syndrome and in acute myeloblastic leukemia associated with trilineage myelodysplasia.
Hicsonmez G, Gumruk F, Cetin M, Ozbek N, Tuncer M, Gursel T.
Turk J Pediatr. 1995;37(4):425-9.
Platelet function was studied in a child with myelodysplastic syndrome (MDS: refractory anemia with an excess of blasts) and a child with acute myeloblastic leukemia (AML-M6) associated with trilineage myelodysplasia (TMDS).
2179635
 MIXED_SAMPLE Adult
Clinical characteristics of hybrid leukemia: report of five cases.
Akashi K, Harada M, Shibuya T, Morioka E, Okamura T, Asano Y, Taniguchi S, Teshima T, Kikuchi M, Niho Y.
Leuk Res. 1990;14(2):145-53.
Three of the five patients had been suffering from so-called stem cell disorders such as aplastic anemia in patient 2, trilineage myelodysplasia in patient 4 and refractory anemia with excess of blasts in transformation in patient 5.
2588956
 MALE
Systemic lupus erythematosus in a patient with refractory anemia.
Nakayama S, Nakamura F, Yabe H, Nagai K.
Nihon Ketsueki Gakkai Zasshi. 1989;52(6):1072-7.
A 69-year-old man was diagnosed as having refractory anemia (RA), accompanied by pancytopenia of two years' duration, myelodysplasia in all three cell lines, abnormal karyotype of 46, XY, 20q--in bone marrow cells, and positive antinuclear and DNA antibody tests.