Acute myeloblastic leukemia without maturation

A rare, acute myeloid leukemia characterized by no significant myeloid maturation and more than 90% blast cells in the non-erythroid population. Various degrees of anemia, thrombocytopenia, or pancytopenia are present. Frequent clinical manifestations include fatigue, fever, bleeding disorders, and organomegaly, especially hepatosplenomegaly.

Leukemia

A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes.

Total: 6

(per page)

PMID (PMCID)
19027489	MIXED_SAMPLE	Adult
	Jumping translocations in hematological malignancies: a cytogenetic study of five cases.
	Manola KN, Georgakakos VN, Stavropoulou C, Spyridonidis A, Angelopoulou MK, Vlachadami I, Katsigiannis A, Roussou P, Pantelias GE, Sambani C. Cancer Genet Cytogenet. 2008;187(2):85-94.
	These cases involve JT of 1q in a case of acute myeloblastic leukemia (AML)-M1, a case of Burkitt lymphoma, and a case of BCR/ABL-positive acute lymphoblastic leukemia, as well as a JT of 13q in a case of AML-M5, and a JT of 11q segment in a case of undifferentiated leukemia.
19027489	MIXED_SAMPLE	Adult
	Jumping translocations in hematological malignancies: a cytogenetic study of five cases.
	Manola KN, Georgakakos VN, Stavropoulou C, Spyridonidis A, Angelopoulou MK, Vlachadami I, Katsigiannis A, Roussou P, Pantelias GE, Sambani C. Cancer Genet Cytogenet. 2008;187(2):85-94.
	These cases involve JT of 1q in a case of acute myeloblastic leukemia (AML)-M1, a case of Burkitt lymphoma, and a case of BCR/ABL-positive acute lymphoblastic leukemia, as well as a JT of 13q in a case of AML-M5, and a JT of 11q segment in a case of undifferentiated leukemia.
12854906	MALE
	The potential effect of short-course high-dose steroid on the maturation and apoptosis of leukemic cells in a child with acute megakaryoblastic leukemia.
	Hicsonmez G, Cetin M, Okur H, Erdemli E, Gurgey A. Leuk Lymphoma. 2003;44(6):1037-42.
	High-dose methylprednisolone (HDMP) treatment has been shown to induce differentiation of myeloid leukemic cells in children with acute promyelocytic leukemia and other subtypes (FAB AML M1-M2-M4) of acute myeloblastic leukemia.
12096491	MALE
	[Granulocytic sarcoma developing in lymph nodes].
	Watanabe I, Yakushijin Y, Sakai I, Yasukawa M, Fujita S. Rinsho Ketsueki. 2002;43(5):378-83.
	Two months later, however, the patient developed acute myelocytic leukemia (AML M1) and received DCP therapy, but he died of pneumonia.
10785268	MIXED_SAMPLE	Infant
	A novel translocation t(3;22)(q21;q11) involving 3q21 in myelodysplastic syndrome-derived overt leukemia with thrombocytosis.
	Yamamoto K, Nagata K, Tsurukubo Y, Morishita K, Hamaguchi H. Leuk Res. 2000;24(5):453-7.
	After 4 months, blood leukemic cells and platelets rapidly increased concomitantly and a diagnosis of acute myeloblastic leukemia (AML M1) was made.
1942537	FEMALE	Adult
	[Torsade de pointes ventricular tachycardia in a patient with acute myelocytic leukemia].
	Morioka M, Kakinoki Y, Katagiri M, Iwasaki H, Gotohda Y, Kobayashi T, Tanaka M, Sakurada K, Miyazaki T. Rinsho Ketsueki. 1991;32(9):1009-11.
	We experienced Torsade-de-pointes arrhythmia during the treatment of acute myelocytic leukemia (AML); The patient was a 28 year old woman and had an AML-M1.