Acute undifferentiated leukemia

A rare acute leukemia of ambiguous lineage characterized by clonal proliferation of primitive hematopoietic cells, primarily in the bone marrow and blood, lacking lineage-specific markers and detectable genotypic alterations. The patients present with leukocytosis, anemia, variable platelet count and a variety of nonspecific symptoms related to ineffective hematopoesis (fatigue, bleeding and bruising, recurrent infections, bone pain) and/or extramedullary site involvement (lymphadenopathy, splenomegaly, hepatomegaly).

Leukemia

A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes.

Total: 6

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PMID (PMCID)
25673598	FEMALE	Child
	Blastic plasmacytoid dendritic cell neoplasm: report of two pediatric cases.
	Dharmani PA, Mittal NM, Subramanian PG, Galani K, Badrinath Y, Amare P, Gujral S. Indian J Pathol Microbiol. 2015;58(1):72-6.
	The differential diagnoses considered were AML, T/NK-cell leukemia and acute undifferentiated leukemia.
20513125	MALE	Adult
	Mixed phenotype acute leukemia with t(11;19)(q23;p13.3)/ MLL-MLLT1(ENL), B/T-lymphoid type: A first case report.
	Naghashpour M, Lancet J, Moscinski L, Zhang L. Am J Hematol. 2010;85(6):451-4.
	They include leukemias with no lineage specific antigens (acute undifferentiated leukemias) and those with blasts that express antigens of more than one lineage to such degree that it is not possible to assign the leukemia to any one particular lineage with certainty (mixed phenotype acute leukemias).
20513125	MALE	Adult
	Mixed phenotype acute leukemia with t(11;19)(q23;p13.3)/ MLL-MLLT1(ENL), B/T-lymphoid type: A first case report.
	Naghashpour M, Lancet J, Moscinski L, Zhang L. Am J Hematol. 2010;85(6):451-4.
	They include leukemias with no lineage specific antigens (acute undifferentiated leukemias) and those with blasts that express antigens of more than one lineage to such degree that it is not possible to assign the leukemia to any one particular lineage with certainty (mixed phenotype acute leukemias).
1747868	MIXED_SAMPLE	Middle Aged
	Trisomy 13 as a primary chromosome aberration in acute leukemia.
	Mertens F, Sallerfors B, Heim S, Johansson B, Kristoffersson U, Malm C, Mitelman F. Cancer Genet Cytogenet. 1991;56(1):39-44.
	The two patients with acute nonlymphocytic leukemia FAB-type M1 (ANLL-M1) had the karyotypes 47,XY,+13/48,XY,+13,+13 and 47,XX,+13, a patient with the hypogranular form of ANLL M3 had 47,XX, +13, and the fourth patient, who had acute undifferentiated leukemia (AUL), had the karyotype 47,XY,+13/48,XY,+8,+13.
3858611	MIXED_SAMPLE	Middle Aged
	Acute erythroblastic leukemia presenting as acute undifferentiated leukemia: a report of two cases with ultrastructural features.
	Reiffers J, Bernard P, Larrue J, Dachary D, David B, Boisseau M, Broustet A. Leuk Res. 1985;9(3):413-20.
	Acute erythroblastic leukemia presenting as acute undifferentiated leukemia: a report of two cases with ultrastructural features.
3971322	FEMALE	Adult
	Chromosome 12 rearrangement with breakage at the p11 level in hematologic disorders: report of four cases.
	Zaccaria A, Rosti G, Testoni N, Tura S. Cancer Genet Cytogenet. 1985;15(3-4):309-14.
	One had acute promyelocytic leukemia, one had myelofibrosis evoluting to acute undifferentiated leukemia, one had acute nonlymphoid leukemia (ANLL) secondary to Hodgkin's disease, and another had acute leukemia recurring after allogeneic bone marrow transplantation.