Legg-Calvé-Perthes disease

A rare disorder characterized by uni- or bilateral avascular necrosis (AVN) of the femoral head in children.



Input patient's signs and symptoms


Narrow down the case reports



Total: 84 (papers)

  


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)
PMID
(PMCID)
67
(4.0%)
2658914
Ultrasonography of the hip for Perthes' disease.
Linnenbaum FJ, Woltering H, Karbowski A, Harle A.
Arch Orthop Trauma Surg. 1989;108(3):166-72.
Aspiration
Child Child, Preschool Femur Head Necrosis Hip Joint Homo sapiens Legg-Calve-Perthes Disease Male Time Factors Ultrasonography
67
(4.0%)
1558778
Development of Perthes' disease in a 3-year-old boy with idiopathic thrombocytopenic purpura and antiphospholipid antibodies.
Ura Y, Hara T, Mori Y, Matsuo M, Fujioka Y, Kuno T, Okue A, Miyazaki S.
Pediatr Hematol Oncol. 1992;9(1):77-80.
Purpura
Antiphospholipid Syndrome Autoantibodies Child, Preschool Homo sapiens Legg-Calve-Perthes Disease Male
67
(4.0%)
917961
Perthes' disease and multiple epiphyseal dysplasia.
Griffiths HE, Witherow PJ.
Postgrad Med J. 1977;53(622):464-72.
Hip pain
Child Child, Preschool Chondrodysplasia Punctata Differential Diagnosis Hip Joint Homo sapiens Legg-Calve-Perthes Disease Male Osteochondritis
67
(4.0%)
276512
[Perthes disease after successfully treated acute juvenile lymphoblastic leukemia].
Eckhardt D, Kircher E.
Fortschr Med. 1978;96(31):1569-71.
Leukemia
Child Differential Diagnosis Femur Head Necrosis Homo sapiens Legg-Calve-Perthes Disease Male Osteochondritis
        

Phenotype(s) retrieved from Orphanet

    Total: 8

HPO ID Term Frequency
HP:0000164 Abnormality of the dentition Very frequent (99-80%)
HP:0001373 Joint dislocation Very frequent (99-80%)
HP:0002750 Delayed skeletal maturation Very frequent (99-80%)
HP:0002829 Arthralgia Very frequent (99-80%)
HP:0003202 Skeletal muscle atrophy Very frequent (99-80%)
HP:0004322 Short stature Very frequent (99-80%)
HP:0010885 Avascular necrosis Very frequent (99-80%)
HP:0100773 Cartilage destruction Very frequent (99-80%)


Phenotype(s) retrieved from case reports

    Total: 43

HPO ID Term # of case reports
HP:0003095 Septic arthritis 6
HP:0100769 Synovitis 5
HP:0002656 Epiphyseal dysplasia 4
HP:0002754 Osteomyelitis 4
HP:0002655 Spondyloepiphyseal dysplasia 3
HP:0030838 Hip pain 3
HP:0000821 Hypothyroidism 2
HP:0001369 Arthritis 2
HP:0001909 Leukemia 2
HP:0002758 Osteoarthritis 2
HP:0002812 Coxa vara 2
HP:0008807 Acetabular dysplasia 2
HP:0000100 Nephrotic syndrome 1
HP:0000252 Microcephaly 1
HP:0000324 Facial asymmetry 1
HP:0000639 Nystagmus 1
HP:0000819 Diabetes mellitus 1
HP:0000979 Purpura 1
HP:0001159 Syndactyly 1
HP:0001250 Seizures 1
HP:0001385 Hip dysplasia 1
HP:0001513 Obesity 1
HP:0002301 Hemiplegia 1
HP:0002650 Scoliosis 1
HP:0002721 Immunodeficiency 1
HP:0002808 Kyphosis 1
HP:0002827 Hip dislocation 1
HP:0002857 Genu valgum 1
HP:0002944 Thoracolumbar scoliosis 1
HP:0003302 Spondylolisthesis 1
HP:0003304 Spondylolysis 1
HP:0008843 Hip osteoarthritis 1
HP:0010740 Osteopathia striata 1
HP:0011002 Osteopetrosis 1
HP:0012062 Bone cyst 1
HP:0030431 Osteochondroma 1
HP:0030772 Proximal femoral focal deficiency 1
HP:0030836 Wrist pain 1
HP:0030839 Knee pain 1
HP:0100259 Postaxial polydactyly 1
HP:0100646 Thyroiditis 1
HP:0100777 Exostoses 1
HP:0100806 Sepsis 1


Causative gene(s) retrieved from Orphanet

    Total: 1

Gene Symbol Gene Name Entrez Gene ID
COL2A1 collagen type II alpha 1 chain 1280