Nevus of Ota

Nevus of Ota is an oculodermal melanocytosis more commonly found in Asian and African populations, usually present at birth and characterized by a usually unilateral, bluish gray, patchy, speckled pigmentation (that may progressively enlarge and darken) affecting the skin of the face along the distribution of the ophthalmic and maxillary divisions of the trigeminal nerve (periorbital region, temple, forehead, malar area, nose). In 2/3 cases the ipsilateral sclera is affected. Nevus of Ota usually remains stable once adulthood is reached but an increased risk of glaucoma and uveal melanoma may be observed. Extracutaneous lesions may also occur in cornea, retina, tympanum, nasal mucosa, pharynx, palate. Nevus of Ota occurs as solitary conditions but seldom may occur together with the nevus of Ito or nevus spilus.



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Total: 96 (papers)

   


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Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)		 PMID
(PMCID)
1
(45.7%)		 136926
 Nevus of Ota with ipsilateral congenital cataract.
Gewirtzman GB, Rasmussen JE.
Arch Dermatol. 1976;112(9):1284-5.
Cataract Hemiatrophy
Adult Cataract Down Syndrome Eye Neoplasms Females Homo sapiens Nevus Sclera
2
(29.2%)		 8447671
 Phakomatosis pigmentovascularis type IIb with iris mammillations.
Gilliam AC, Ragge NK, Perez MI, Bolognia JL.
Arch Dermatol. 1993;129(3):340-2.
Nevus flammeus Lisch nodules
Child, Preschool Differential Diagnosis Females Hamartoma Homo sapiens Iris Diseases
3
(17.5%)		 30613434
 Primary meningeal melanocytoma of the cerebellopontine angle associated with ipsilateral nevus of Ota: A case report.
Elbadry R, Elazim AA, Mohamed K, Issa M, Ayyad A.
Surg Neurol Int. 2018;9:245.
Hemangioma Lipoma
3
(17.5%)		 9703145
 Congenital unilateral speckled lentiginous blue nevi with asymmetric spinal muscular atrophy.
Hofmann UB, Ogilvie P, Mullges W, Brocker EB, Hamm H.
J Am Acad Dermatol. 1998;39(2 Pt 2):326-9.
Spinal muscular atrophy
Adult Eye Neoplasms Homo sapiens Lentigo Male Nevus of Ota Nevus, Blue Skin Neoplasms Spinal Muscular Atrophy
3
(17.5%)		 9143428
 Treatment of nevus of Ota by Q-switched ruby laser.
Shimbashi T, Hyakusoku H, Okinaga M.
Aesthetic Plast Surg. 1997;21(2):118-21.
Scarring
Dermatologic Surgical Procedures Face Females Homo sapiens Laser Therapy Nevus of Ota Skin
6
(4.0%)		 31171040
 Nevus of Ota - an intraoral presentation: a case report.
Maguire J, Holt D.
J Med Case Rep. 2019;13(1):174.
Nevus
Facial Neoplasms Females Homo sapiens Middle Aged Mouth Neoplasms Nevus of Ota Skin Neoplasms
6
(4.0%)		 30994485
 Glaucoma in Phacomatosis Pigmentovascularis in a Young African Adolescent Boy: A Case Report.
van der Merwe EB, Bhika RE, Meyer D.
J Glaucoma. 2019;28(7):e124-e125.
Glaucoma
Antihypertensive Agents Glaucoma, Open-Angle Gonioscopy Homo sapiens Male Nerve Fibers Neurocutaneous Syndromes Nevus of Ota Optic Disk Port-Wine Stain Retinal Ganglion Cells South Africa Tomography, Optical Coherence Ultrasonography
6
(4.0%)		 30686121
 Oculodermal Melanocytosis: Nevus of Ota in a Dog.
Giannikaki S, Sturgess K, Scurrell E, Cebrian P, Escanilla N, Lowe RC.
Vet Pathol. 2019;56(3):460-464.
Hamartoma
Animals Canis familiaris Dog Diseases Eye Neoplasms Male Nevus of Ota Sclera Skin Neoplasms
6
(4.0%)		 30372724
 Nevus of Ota associated with a primary uveal melanoma and intracranial melanoma metastasis.
Konstantinov NK, Berry TM, Elwood HR, Zlotoff BJ.
Cutis. 2018;102(3):E2-E4.
Melanoma
Adult Brain Neoplasms Females GTP-Binding Protein alpha Subunits, Gq-G11 Homo sapiens Nevus of Ota Tumor Suppressor Proteins Uveal Neoplasms
6
(4.0%)		 30007908
 Port-wine stain as a clue for two rare coexisting entities.
Almeida FT, Caldas R, Duarte MDL, Brito C.
BMJ Case Rep. 2018;2018:.
Overgrowth
Adult Differential Diagnosis Homo sapiens Klippel-Trenaunay-Weber Syndrome Male Melanosis Neurocutaneous Syndromes Port-Wine Stain
        

Phenotype(s) retrieved from Orphanet

    Total: 0

HPO ID Term Frequency


Phenotype(s) retrieved from case reports

    Total: 30

HPO ID Term # of case reports
HP:0002861 Melanoma 24
HP:0100814 Blue nevus 15
HP:0003764 Nevus 12
HP:0012733 Macule 9
HP:0000501 Glaucoma 7
HP:0001052 Nevus flammeus 4
HP:0000518 Cataract 2
HP:0000995 Melanocytic nevus 2
HP:0010566 Hamartoma 2
HP:0012056 Cutaneous melanoma 2
HP:0025510 Nevus spilus 2
HP:0100008 Schwannoma 2
HP:0000572 Visual loss 1
HP:0000853 Goiter 1
HP:0000989 Pruritus 1
HP:0001045 Vitiligo 1
HP:0001048 Cavernous hemangioma 1
HP:0001250 Seizures 1
HP:0001268 Mental deterioration 1
HP:0001269 Hemiparesis 1
HP:0002290 Poliosis 1
HP:0002321 Vertigo 1
HP:0007832 Pigmentation of the sclera 1
HP:0007906 Ocular hypertension 1
HP:0009916 Anisocoria 1
HP:0012108 Open angle glaucoma 1
HP:0025104 Capillary malformation 1
HP:0025105 Nevus anemicus 1
HP:0025272 Melasma 1
HP:0100556 Hemiatrophy 1


Causative gene(s) retrieved from Orphanet

    Total: 0

Gene Symbol Gene Name Entrez Gene ID