Nevus of Ota

Nevus of Ota is an oculodermal melanocytosis more commonly found in Asian and African populations, usually present at birth and characterized by a usually unilateral, bluish gray, patchy, speckled pigmentation (that may progressively enlarge and darken) affecting the skin of the face along the distribution of the ophthalmic and maxillary divisions of the trigeminal nerve (periorbital region, temple, forehead, malar area, nose). In 2/3 cases the ipsilateral sclera is affected. Nevus of Ota usually remains stable once adulthood is reached but an increased risk of glaucoma and uveal melanoma may be observed. Extracutaneous lesions may also occur in cornea, retina, tympanum, nasal mucosa, pharynx, palate. Nevus of Ota occurs as solitary conditions but seldom may occur together with the nevus of Ito or nevus spilus.



Input patient's signs and symptoms


Narrow down the case reports



Total: 96 (papers)

   


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)		 PMID
(PMCID)
6
(4.0%)		 29687085
(5910506)
 Orbital melanocytoma: When a tumor becomes a relieving surprise.
Nasr HE, Nouh MA, Ahmed RA, Elhusseiny AM.
Am J Ophthalmol Case Rep. 2018;10:124-127.
Proptosis
6
(4.0%)		 29449519
 [Supratentorial Meningeal Melanoma with Nevus of Ota:A Case Report].
Shima S, Sato S, Moteki Y, Inoue T, Suzuki K, Niimi Y, Okada Y.
No Shinkei Geka. 2018;46(2):139-145.
Melanoma
Adult Homo sapiens Magnetic Resonance Imaging Male Meningeal Neoplasms Multimodal Imaging Neurosurgical Procedures X-Ray Computed Tomography
6
(4.0%)		 28745006
 Nevus of Ota (oculodermal melanocytosis) in a dog.
Malho P, Shea A, Donaldson D.
Vet Ophthalmol. 2018;21(3):312-318.
Glaucoma
Animals Canis familiaris Dog Diseases Females Nevus of Ota Skin Neoplasms
6
(4.0%)		 28728861
 [Vitiligo occurring on dermal melanocytosis (nevus of Ota) in a dark-skinned patient].
Ahogo KC, Gbery IP, Vagamon B, Ouattara OA, Kouassi KA, Kourouma HS, Kouassi YI.
Ann Dermatol Venereol. 2017;144(11):712-714.
Glaucoma
Females Homo sapiens Nevus of Ota Sclera Skin Neoplasms Skin Pigmentation Vitiligo Young Adult
6
(4.0%)		 28302248
 Ocular Features in a Case of Nevus of Ota.
Junejo MS, Khan MS, Mukhtar A.
J Coll Physicians Surg Pak. 2017;27(3):S56-S57.
Glaucoma
Adult Homo sapiens Male Nevus of Ota Skin Neoplasms Vision Disorders
6
(4.0%)		 27699140
(5039011)
 An Orbital Malignant Melanoma Arising in Cellular Blue Nevus in a Patient with Nevus of Ota.
Buntinx-Krieg T, Ouyang J, Cartwright M.
Cureus. 2016;8(7):e698.
Proptosis
6
(4.0%)		 26701415
 Genetic evolution of nevus of Ota reveals clonal heterogeneity acquiring BAP1 and TP53 mutations.
Vivancos A, Caratu G, Matito J, Munoz E, Ferrer B, Hernandez-Losa J, Bodet D, Perez-Alea M, Cortes J, Garcia-Patos V, Recio JA.
Pigment Cell Melanoma Res. 2016;29(2):247-53.
Melanoma
Adult Females GTP-Binding Protein alpha Subunits, Gq-G11 Head and Neck Neoplasms Homo sapiens Nevus of Ota Skin Neoplasms Tumor Suppressor Proteins
6
(4.0%)		 26312661
(4540495)
 The case of a boy with nevus of Ota, extensive Mongolian spot, nevus flammeus, nevus anemicus and cutis marmorata telangiectatica congenita: a unique instance of phacomatosis pigmentovascularis.
Ma H, Liao M, Qiu S, Luo R, Lu R, Lu C.
An Bras Dermatol. 2015;90(3 Suppl 1):10-2.
Nevus flammeus
Homo sapiens Livedo Reticularis Male Mongolian Spot Neurocutaneous Syndromes Nevus of Ota Port-Wine Stain Skin Diseases, Vascular Skin Neoplasms Telangiectasis Young Adult
6
(4.0%)		 26260725
 Melanoma arising in a nevus of Ito: novel genetic mutations and a review of the literature on cutaneous malignant transformation of dermal melanocytosis.
Tse JY, Walls BE, Pomerantz H, Yoon CH, Buchbinder EI, Werchniak AE, Dong F, Lian CG, Granter SR.
J Cutan Pathol. 2016;43(1):57-63.
Melanoma
rs397507456 rs550707862 rs562517792
Adult Females GTP-Binding Protein alpha Subunits, Gq-G11 Genetic Predisposition to Disease High-Throughput Nucleotide Sequencing Homo sapiens Male Middle Aged Mutation Neoplastic Cell Transformation Skin Neoplasms Tumor Suppressor Proteins Young Adult
6
(4.0%)		 26121271
 Giant Blue Nevus: A New Association to Nevus of Ota.
Medel R, Vasquez L, Fernandez J, Huguet P, Pamias J.
Orbit. 2015;34(4):223-8.
Melanoma
Diagnostic Imaging Differential Diagnosis Eye Neoplasms Homo sapiens Male Nevus of Ota Nevus, Blue Young Adult
        

Phenotype(s) retrieved from Orphanet

    Total: 0

HPO ID Term Frequency


Phenotype(s) retrieved from case reports

    Total: 30

HPO ID Term # of case reports
HP:0002861 Melanoma 24
HP:0100814 Blue nevus 15
HP:0003764 Nevus 12
HP:0012733 Macule 9
HP:0000501 Glaucoma 7
HP:0001052 Nevus flammeus 4
HP:0000518 Cataract 2
HP:0000995 Melanocytic nevus 2
HP:0010566 Hamartoma 2
HP:0012056 Cutaneous melanoma 2
HP:0025510 Nevus spilus 2
HP:0100008 Schwannoma 2
HP:0000572 Visual loss 1
HP:0000853 Goiter 1
HP:0000989 Pruritus 1
HP:0001045 Vitiligo 1
HP:0001048 Cavernous hemangioma 1
HP:0001250 Seizures 1
HP:0001268 Mental deterioration 1
HP:0001269 Hemiparesis 1
HP:0002290 Poliosis 1
HP:0002321 Vertigo 1
HP:0007832 Pigmentation of the sclera 1
HP:0007906 Ocular hypertension 1
HP:0009916 Anisocoria 1
HP:0012108 Open angle glaucoma 1
HP:0025104 Capillary malformation 1
HP:0025105 Nevus anemicus 1
HP:0025272 Melasma 1
HP:0100556 Hemiatrophy 1


Causative gene(s) retrieved from Orphanet

    Total: 0

Gene Symbol Gene Name Entrez Gene ID