Nevus of Ota

Nevus of Ota is an oculodermal melanocytosis more commonly found in Asian and African populations, usually present at birth and characterized by a usually unilateral, bluish gray, patchy, speckled pigmentation (that may progressively enlarge and darken) affecting the skin of the face along the distribution of the ophthalmic and maxillary divisions of the trigeminal nerve (periorbital region, temple, forehead, malar area, nose). In 2/3 cases the ipsilateral sclera is affected. Nevus of Ota usually remains stable once adulthood is reached but an increased risk of glaucoma and uveal melanoma may be observed. Extracutaneous lesions may also occur in cornea, retina, tympanum, nasal mucosa, pharynx, palate. Nevus of Ota occurs as solitary conditions but seldom may occur together with the nevus of Ito or nevus spilus.



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Narrow down the case reports



Total: 96 (papers)

   


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)		 PMID
(PMCID)
6
(4.0%)		 23571263
(3744789)
 Orbital malignant melanoma associated with nevus of Ota.
Radhadevi CV, Charles KS, Lathika VK.
Indian J Ophthalmol. 2013;61(6):306-9.
Melanoma
Homo sapiens Male Middle Aged Neoplasms, Second Primary Neoplastic Cell Transformation Nevus of Ota Orbital Neoplasms Skin Neoplasms
6
(4.0%)		 23456162
 'Nevi of Ota: the unusual birthmarks': a case review.
Mohan RP, Verma S, Singh AK, Singh U.
BMJ Case Rep. 2013;2013:.
Nevus
Adult Biopsy Differential Diagnosis Females Homo sapiens Nevus of Ota Skin Neoplasms
6
(4.0%)		 22567445
(3335646)
 Nevus of ota with rare palatal involvement: a case report with emphasis on differential diagnosis.
Sharma G, Nagpal A.
Case Rep Dent. 2011;2011:670679.
Melanocytic nevus
6
(4.0%)		 22508370
 Giant Mongolian macules with bilateral ocular involvement: case report and review.
Kose O, Huseynov S, Demiriz M.
Dermatology. 2012;224(2):126-9.
Macule
Females Homo sapiens Hyperpigmentation Infant Mongolian Spot Scleral Diseases Skin Neoplasms
6
(4.0%)		 21924617
 Intracranial meningeal melanocytoma associated with nevus of Ota.
Pan H, Wang H, Fan Y.
J Clin Neurosci. 2011;18(11):1548-50.
Ptosis
Adult Homo sapiens Male Meningeal Neoplasms Nevus of Ota Skin Neoplasms
6
(4.0%)		 21548520
 Pseudoxanthoma elasticum: clinical, histologic, and genetic studies--a report of two sisters.
Kaimbo DK, Mutosh A, Leys A, Parys-van Ginderdeuren R, Bergen AA.
Skinmed. 2011;9(2):119-21.
Hypertension
Adult Angioid Streaks Biopsy Calcinosis Elastic Tissue Females Homo sapiens Pseudoxanthoma Elasticum Skin Visual Acuity Young Adult
6
(4.0%)		 21186017
 Malignant melanoma of the choroid in the eye with oculodermal melanocytosis of a Chinese woman.
Chen YC, Chang CH, Hsu SL, Hsu MW, Lee CL.
Kaohsiung J Med Sci. 2010;26(12):673-8.
Melanoma
Choroid Neoplasms Females Homo sapiens Nevus of Ota
6
(4.0%)		 21165221
 An unusual case of congenital dermal melanocytosis.
Lee S, Kim DH, Lee G, Whang KU, Lee JS, Park YL.
Ann Dermatol. 2010;22(4):460-2.
Blue nevus
6
(4.0%)		 20548900
 A malignant melanoma associated with a blue nevus of the lip.
Lee HY, Na SY, Son YM, Kang HK, Baek JO, Lee JR, Roh JY.
Ann Dermatol. 2010;22(1):119-24.
Melanoma
6
(4.0%)		 20361651
 [Congenital ocular melanocytosis and delayed psycho-intellectual development--a new association?].
Bivolaru I, Selaru D, Serghiescu I.
Oftalmologia. 2009;53(4):53-7.
Glaucoma
Child Developmental Disabilities Differential Diagnosis Homo sapiens Male Melanosis Sclera
        

Phenotype(s) retrieved from Orphanet

    Total: 0

HPO ID Term Frequency


Phenotype(s) retrieved from case reports

    Total: 30

HPO ID Term # of case reports
HP:0002861 Melanoma 24
HP:0100814 Blue nevus 15
HP:0003764 Nevus 12
HP:0012733 Macule 9
HP:0000501 Glaucoma 7
HP:0001052 Nevus flammeus 4
HP:0000518 Cataract 2
HP:0000995 Melanocytic nevus 2
HP:0010566 Hamartoma 2
HP:0012056 Cutaneous melanoma 2
HP:0025510 Nevus spilus 2
HP:0100008 Schwannoma 2
HP:0000572 Visual loss 1
HP:0000853 Goiter 1
HP:0000989 Pruritus 1
HP:0001045 Vitiligo 1
HP:0001048 Cavernous hemangioma 1
HP:0001250 Seizures 1
HP:0001268 Mental deterioration 1
HP:0001269 Hemiparesis 1
HP:0002290 Poliosis 1
HP:0002321 Vertigo 1
HP:0007832 Pigmentation of the sclera 1
HP:0007906 Ocular hypertension 1
HP:0009916 Anisocoria 1
HP:0012108 Open angle glaucoma 1
HP:0025104 Capillary malformation 1
HP:0025105 Nevus anemicus 1
HP:0025272 Melasma 1
HP:0100556 Hemiatrophy 1


Causative gene(s) retrieved from Orphanet

    Total: 0

Gene Symbol Gene Name Entrez Gene ID