Congenital varicella syndrome

Fetal varicella syndrome (CVS) is an acquired developmental anomaly syndrome characterized by skin, neurological, ocular, limbs and growth defects secondary to maternal Varicella-Zoster Virus (VZV) infection.



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Narrow down the case reports



Total: 29 (papers)

   


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)		 PMID
(PMCID)
1
(39.0%)		 10206169
 Congenital varicella syndrome: cranial MRI in a long-term survivor.
Deasy NP, Jarosz JM, Cox TC, Hughes E.
Neuroradiology. 1999;41(3):205-7.
Microcephaly
Brain Chickenpox Females Homo sapiens Leg Magnetic Resonance Imaging Male Pregnancy Pregnancy Complications, Infectious Survivors
1
(39.0%)		 1743417
 Severe microcephaly associated with congenital varicella infection.
Scheffer IE, Baraitser M, Brett EM.
Dev Med Child Neurol. 1991;33(10):916-20.
Microcephaly
Chickenpox Females Homo sapiens Infant Microcephaly Neurologic Examination Pregnancy Pregnancy Complications, Infectious Pregnancy Trimester, Second X-Ray Computed Tomography
3
(30.2%)		 28331020
 Isolated lower limb hypoplasia secondary to congenital varicella syndrome: a rare occurrence and management of its complications.
Mehta S, Schenk W, Kirker S, Atrey A.
BMJ Case Rep. 2017;2017:.
Muscle weakness Femur fracture
Adult Amputation Chickenpox Females Femoral Fractures Homo sapiens Hypesthesia Leg Leg Injuries Syndrome
4
(20.4%)		 16601342
 Prenatal ultrasound diagnosis, follow-up, and outcome of congenital varicella syndrome.
Meyberg-Solomayer GC, Fehm T, Muller-Hansen I, Enders G, Poets C, Wallwiener D, Solomayer EF.
Fetal Diagn Ther. 2006;21(3):296-301.
Encephalopathy Myocardial calcification
Brain Diseases Calcinosis Chickenpox Fatal Outcome Females Fetal Diseases Fetal Growth Retardation Gestational Age Homo sapiens Infant, Newborn Limb Deformities, Congenital Magnetic Resonance Imaging Pregnancy Pregnancy Outcome Ultrasonography, Prenatal
5
(17.5%)		 19054581
 Unilateral laryngeal paralysis in a newborn with congenital varicella syndrome.
Rizzardi E, Tagliaferro T, Snijders D, Bertuola F, Spolaore F, Monciotti CM, Cermakova I, Barbato A.
Int J Pediatr Otorhinolaryngol. 2009;73(1):115-8.
Failure to thrive Chorioretinal scar
RET
Chickenpox Homo sapiens Infant, Newborn Male Positive-Pressure Respiration Syndrome Vocal Cord Paralysis
5
(17.5%)		 14992768
 [Two cases of congenital varicella syndrome: plea for the varicella vaccine].
Bruel H, Chabrolle JP, El Khoury E, Poinsot J, Amusini P, Beurrier J.
Arch Pediatr. 2004;11(3):216-8.
Scarring
Chickenpox Chickenpox Vaccine Females Homo sapiens Infant, Newborn Male
5
(17.5%)		 12619963
 Congenital varicella syndrome.
Sasidharan CK, Anoop P.
Indian J Pediatr. 2003;70(1):101-3.
Hernia
Chickenpox Cicatrix Females Fetal Diseases Homo sapiens Infant, Newborn Limb Deformities, Congenital Microcephaly Pregnancy Pregnancy Complications, Infectious Pregnancy Trimester, First Syndrome Ventral Hernia
5
(17.5%)		 10760023
 Congenital varicella syndrome diagnosed by polymerase chain reaction--scarring of the spinal cord, not the skin.
Cooper C, Wojtulewicz J, Ratnamohan VM, Arbuckle S.
J Paediatr Child Health. 2000;36(2):186-8.
Gliosis Scarring
Chickenpox Cicatrix Congenital Hand Deformities Females Homo sapiens Infant, Newborn Polymerase Chain Reaction Skin Spinal Cord Syndrome Toes
5
(17.5%)		 7198579
 The congenital varicella syndrome.
Borzyskowski M, Harris RF, Jones RW.
Eur J Pediatr. 1981;137(3):335-8.
Paralysis Scarring
Chickenpox Child, Preschool Cicatrix Females Homo sapiens Horner Syndrome Infant Neurogenic Urinary Bladder Pregnancy Pregnancy Complications, Infectious Syndrome
5
(17.5%)		 2910286
 Ocular manifestations of the congenital varicella syndrome.
Lambert SR, Taylor D, Kriss A, Holzel H, Heard S.
Arch Ophthalmol. 1989;107(1):52-6.
Cataract Bulbar palsy
Chickenpox Child, Preschool Choroid Females Homo sapiens Infant Male Pregnancy Pregnancy Complications, Infectious Retina
        

Phenotype(s) retrieved from Orphanet

    Total: 9

HPO ID Term Frequency
HP:0000987 Atypical scarring of skin Very frequent (99-80%)
HP:0001511 Intrauterine growth retardation Very frequent (99-80%)
HP:0000252 Microcephaly Frequent (79-30%)
HP:0000518 Cataract Frequent (79-30%)
HP:0000568 Microphthalmia Frequent (79-30%)
HP:0001249 Intellectual disability Frequent (79-30%)
HP:0001263 Global developmental delay Frequent (79-30%)
HP:0002120 Cerebral cortical atrophy Frequent (79-30%)
HP:0002983 Micromelia Frequent (79-30%)


Phenotype(s) retrieved from case reports

    Total: 10

HPO ID Term # of case reports
HP:0000011 Neurogenic bladder 1
HP:0000076 Vesicoureteral reflux 1
HP:0000238 Hydrocephalus 1
HP:0000252 Microcephaly 1
HP:0001100 Heterochromia iridis 1
HP:0001511 Intrauterine growth retardation 1
HP:0002090 Pneumonia 1
HP:0003470 Paralysis 1
HP:0007777 Chorioretinal scar 1
HP:0100699 Scarring 1


Causative gene(s) retrieved from Orphanet

    Total: 0

Gene Symbol Gene Name Entrez Gene ID