Immune thrombocytopenic purpura

Immune thrombocytopenic purpura (or immune thrombocytopenia; ITP) is an autoimmune coagulation disorder characterized by isolated thrombocytopenia (a platelet count <100,000/microL), in the absence of any underlying disorder that may be associated with thrombocytopenia.



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Narrow down the case reports



Total: 786 (papers)

   


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)		 PMID
(PMCID)
1
(57.8%)		 11878585
 Thrombocytopenia absent corpus callosum syndrome: third case of a distinct clinical entity.
Khabbaze Y, Karayalcin G, Paley C, Shende A, Valderrama E, Lipton JM.
J Pediatr Hematol Oncol. 2001;23(7):469-71.
Microcephaly Micrognathia
Adult Child Child, Preschool Developmental Disabilities Face Females Homo sapiens Infant Male Syndrome Thrombocytopenia X-Ray Computed Tomography
2
(50.2%)		 29464836
 The presentation and management of platelet disorders in pregnancy.
Goldman BG, Hehir MP, Yambasu S, O'Donnell EM.
Eur J Haematol. 2018;100(6):560-566.
Thrombocytopenia Absent radius
Adult Biological Markers Blood Platelet Disorders Disease Management Females Homo sapiens Incidence Phenotype Pregnancy Pregnancy Complications, Hematologic
3
(39.3%)		 12426665
 Aplastic anemia complicating systemic lupus erythematosus--report of a case and review of the literature.
Pavithran K, Raji NL, Thomas M.
Rheumatol Int. 2002;22(6):253-5.
Oral ulcer Arthritis
Adult Anabolic Agents Aplastic Anemia Blood Component Transfusion Fatal Outcome Females Glucocorticoids Homo sapiens Lupus Erythematosus, Systemic Pancytopenia
3
(39.3%)		 8228799
 Polyautoimmune syndrome in common variable immunodeficiency.
Tanus T, Levinson AI, Atkins PC, Zweiman B.
J Intern Med. 1993;234(5):525-7.
Rheumatoid arthritis Parotitis
Autoimmune Diseases Common Variable Immunodeficiency Females Homo sapiens Syndrome
5
(39.0%)		 27835759
(5233712)
 Zika virus epidemic in Brazil. I. Fatal disease in adults: Clinical and laboratorial aspects.
Azevedo RS, Araujo MT, Martins Filho AJ, Oliveira CS, Nunes BT, Cruz AC, Nascimento AG, Medeiros RC, Caldas CA, Araujo FC, Quaresma JA, Vasconcelos BC, Queiroz MG, da Rosa ES, Henriques DF, Silva EV, Chiang JO, Martins LC, Medeiros DB, Lima JA, Nunes MR, Cardoso JF, Silva SP, Shi PY, Tesh RB, Rodrigues SG, Vasconcelos PF.
J Clin Virol. 2016;85:56-64.
Microcephaly
Adult Antigens, Viral Autopsy Brain Brazil Fatal Outcome Females Homo sapiens Immunohistochemistry Male RNA, Viral Real-Time Polymerase Chain Reaction Virus Cultivation Viscera Young Adult Zika Virus Zika Virus Infection
6
(27.8%)		 30659003
 Immune thrombocytopenic purpura presenting with spontaneous gingival haemorrhage in pregnancy.
Dunphy L, Williams R.
BMJ Case Rep. 2019;12(1):.
Gingival bleeding
Adult Females Gingival Hemorrhage Homo sapiens Pregnancy Pregnancy Complications
6
(27.8%)		 30536273
 Refractory Severe Thrombocytopenia during Pregnancy: How to Manage.
Amorim JG, Abecasis MR, Rodrigues FMNL.
Rev Bras Ginecol Obstet. 2018;40(12):803-807.
Gingival bleeding
Females Homo sapiens Pregnancy Pregnancy Complications, Hematologic Severity of Illness Index Thrombocytopenia Young Adult
6
(27.8%)		 29854891
(5960737)
 Immune Thrombocytopenic Purpura Detected with Oral Hemorrhage: a Case Report.
Sugiura T, Yamamoto K, Murakami K, Horita S, Matsusue Y, Nakashima C, Kirita T.
J Dent (Shiraz). 2018;19(2):159-163.
Gingival bleeding
6
(27.8%)		 26367782
 Pancytopenia As the Initial Manifestation of Brucellosis in Children.
Karli A, Sensoy G, Albayrak C, Koken O, Crakl S, Belet N, Albayrak D.
Vector Borne Zoonotic Dis. 2015;15(9):545-9.
Gingival bleeding
Agglutination Tests Animals Brucellosis Child Differential Diagnosis Endemic Diseases Females Fever Hemorrhagic Fever, Crimean Hepatomegaly Homo sapiens Male Pancytopenia Splenomegaly Thrombocytopenia Zoonoses
6
(27.8%)		 26120311
(4478340)
 Metastatic Breast Cancer with Extensive Osseous Metastasis Presenting with Symptomatic Immune Thrombocytopenic Purpura and Anemia: A Case Report and Review of the Literature.
Niu J, Goldin T, Markman M, Kundranda MN.
Case Rep Oncol. 2015;8(2):256-63.
Gingival bleeding
        

Phenotype(s) retrieved from Orphanet

    Total: 10

HPO ID Term Frequency
HP:0001873 Thrombocytopenia Very frequent (99-80%)
HP:0001907 Thromboembolism Very frequent (99-80%)
HP:0000967 Petechiae Frequent (79-30%)
HP:0000979 Purpura Frequent (79-30%)
HP:0004420 Arterial thrombosis Frequent (79-30%)
HP:0000225 Gingival bleeding Occasional (29-5%)
HP:0000421 Epistaxis Occasional (29-5%)
HP:0000978 Bruising susceptibility Occasional (29-5%)
HP:0002239 Gastrointestinal hemorrhage Occasional (29-5%)
HP:0001342 Cerebral hemorrhage Very rare (4-1%)


Phenotype(s) retrieved from case reports

    Total: 145

HPO ID Term # of case reports
HP:0001873 Thrombocytopenia 106
HP:0000979 Purpura 38
HP:0001878 Hemolytic anemia 21
HP:0001875 Neutropenia 17
HP:0012115 Hepatitis 15
HP:0001909 Leukemia 10
HP:0002170 Intracranial hemorrhage 9
HP:0001903 Anemia 8
HP:0001945 Fever 8
HP:0002090 Pneumonia 8
HP:0004844 Coombs-positive hemolytic anemia 8
HP:0100279 Ulcerative colitis 8
HP:0001370 Rheumatoid arthritis 7
HP:0002721 Immunodeficiency 7
HP:0001658 Myocardial infarction 6
HP:0001747 Accessory spleen 6
HP:0002960 Autoimmunity 6
HP:0002716 Lymphadenopathy 5
HP:0005521 Disseminated intravascular coagulation 5
HP:0100646 Thyroiditis 5
HP:0200123 Chronic hepatitis 5
HP:0000821 Hypothyroidism 4
HP:0000967 Petechiae 4
HP:0001287 Meningitis 4
HP:0001744 Splenomegaly 4
HP:0011974 Myelofibrosis 4
HP:0030731 Carcinoma 4
HP:0040185 Macrothrombocytopenia 4
HP:0000100 Nephrotic syndrome 3
HP:0000822 Hypertension 3
HP:0000836 Hyperthyroidism 3
HP:0001394 Cirrhosis 3
HP:0002140 Ischemic stroke 3
HP:0002829 Arthralgia 3
HP:0002840 Lymphadenitis 3
HP:0005523 Lymphoproliferative disorder 3
HP:0005575 Hemolytic-uremic syndrome 3
HP:0200119 Acute hepatitis 3
HP:0000112 Nephropathy 2
HP:0000421 Epistaxis 2
HP:0001045 Vitiligo 2
HP:0001876 Pancytopenia 2
HP:0001971 Hypersplenism 2
HP:0002315 Headache 2
HP:0002835 Aspiration 2
HP:0002861 Melanoma 2
HP:0003326 Myalgia 2
HP:0003641 Hemoglobinuria 2
HP:0005263 Gastritis 2
HP:0005305 Cerebral venous thrombosis 2
HP:0006725 Pancreatic adenocarcinoma 2
HP:0012486 Myelitis 2
HP:0030127 Endometriosis 2
HP:0031864 Bacteremia 2
HP:0032366 Positive direct antiglobulin test 2
HP:0000123 Nephritis 1
HP:0000138 Ovarian cyst 1
HP:0000225 Gingival bleeding 1
HP:0000388 Otitis media 1
HP:0000790 Hematuria 1
HP:0000819 Diabetes mellitus 1
HP:0000846 Adrenal insufficiency 1
HP:0000869 Secondary amenorrhea 1
HP:0000876 Oligomenorrhea 1
HP:0000961 Cyanosis 1
HP:0000964 Eczema 1
HP:0000988 Skin rash 1
HP:0001028 Hemangioma 1
HP:0001324 Muscle weakness 1
HP:0001369 Arthritis 1
HP:0001409 Portal hypertension 1
HP:0001433 Hepatosplenomegaly 1
HP:0001513 Obesity 1
HP:0001733 Pancreatitis 1
HP:0001880 Eosinophilia 1
HP:0001882 Leukopenia 1
HP:0001894 Thrombocytosis 1
HP:0001896 Reticulocytopenia 1
HP:0001905 Congenital thrombocytopenia 1
HP:0001937 Microangiopathic hemolytic anemia 1
HP:0001974 Leukocytosis 1
HP:0002014 Diarrhea 1
HP:0002018 Nausea 1
HP:0002039 Anorexia 1
HP:0002045 Hypothermia 1
HP:0002113 Pulmonary infiltrates 1
HP:0002133 Status epilepticus 1
HP:0002204 Pulmonary embolism 1
HP:0002488 Acute leukemia 1
HP:0002647 Aortic dissection 1
HP:0002664 Neoplasm 1
HP:0002777 Tracheal stenosis 1
HP:0002781 Upper airway obstruction 1
HP:0002863 Myelodysplasia 1
HP:0002933 Ventral hernia 1
HP:0003002 Breast carcinoma 1
HP:0003072 Hypercalcemia 1
HP:0003095 Septic arthritis 1
HP:0003493 Antinuclear antibody positivity 1
HP:0003974 Absent radius 1
HP:0004386 Gastrointestinal inflammation 1
HP:0004419 Recurrent thrombophlebitis 1
HP:0004420 Arterial thrombosis 1
HP:0004809 Neonatal alloimmune thrombocytopenia 1
HP:0004854 Intermittent thrombocytopenia 1
HP:0004936 Venous thrombosis 1
HP:0005112 Abdominal aortic aneurysm 1
HP:0005200 Retroperitoneal fibrosis 1
HP:0005202 Helicobacter pylori infection 1
HP:0006846 Acute encephalopathy 1
HP:0007819 Presenile cataracts 1
HP:0008404 Nail dystrophy 1
HP:0009830 Peripheral neuropathy 1
HP:0011110 Tonsillitis 1
HP:0011854 Hemoperitoneum 1
HP:0012089 Arteritis 1
HP:0012118 Laryngeal carcinoma 1
HP:0012119 Methemoglobinemia 1
HP:0012224 Circulating immune complexes 1
HP:0012226 Ovarian teratoma 1
HP:0012234 Agranulocytosis 1
HP:0012378 Fatigue 1
HP:0012531 Pain 1
HP:0012578 Membranous nephropathy 1
HP:0012735 Cough 1
HP:0012847 Epilepsia partialis continua 1
HP:0025289 Cervical lymphadenopathy 1
HP:0025343 Lupus anticoagulant 1
HP:0025388 Thyroid nodule 1
HP:0030049 Brain abscess 1
HP:0030150 Plasmacytosis 1
HP:0030242 Portal vein thrombosis 1
HP:0030402 Abnormal platelet aggregation 1
HP:0031035 Chronic infection 1
HP:0031273 Shock 1
HP:0031364 Ecchymosis 1
HP:0031690 Opportunistic infection 1
HP:0040184 Oral bleeding 1
HP:0100537 Fasciitis 1
HP:0100584 Endocarditis 1
HP:0100658 Cellulitis 1
HP:0100726 Kaposi's sarcoma 1
HP:0100778 Cryoglobulinemia 1
HP:0100827 Lymphocytosis 1
HP:0200120 Chronic active hepatitis 1


Causative gene(s) retrieved from Orphanet

    Total: 1

Gene Symbol Gene Name Entrez Gene ID
FCGR2C Fc fragment of IgG receptor IIc (gene/pseudogene) 9103