Lead poisoning

Lead poisoning is defined as acute or chronic exposure to lead resulting in lead accumulation (blood lead concentration (BLC) >5 ug/dL) that can affect every organ system in the body and to which children are more susceptible. Clinical manifestations depend on the amount and duration of exposure and include abdominal pain, colic, constipation, lead line on gingival tissue, arthralgia, myalgia, peripheral neuropathy, fatigue, irritability, anemia, chronic nephropathy and hypertension. In children, even low levels of exposure (BLC <5 ug/dL) is reported to lead to irreversible effects such as loss of cognition, shortening of attention span, alteration of behavior, dyslexia, attention deficit disorder, hypertension, renal impairment, immunotoxicity and toxicity to the reproductive organs.



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Total: 297 (papers)

   


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)		 PMID
(PMCID)
1
(50.6%)		 15309279
 [Lead poisoning after ingestion of ayurvedic drugs].
Schilling U, Muck R, Heidemann E.
Med Klin (Munich). 2004;99(8):476-80.
Normocytic anemia Vomiting Hyponatremia Poikilocytosis
Anemia Differential Diagnosis Females Homo sapiens Lead Poisoning Medicine, Ayurvedic Middle Aged Rheumatoid Arthritis Time Factors
2
(50.0%)		 3059486
 [Unusual features in Glanzmann thrombasthenia; proliferation of B-lymphocytes, lead poisoning].
Bucher U.
Schweiz Med Wochenschr. 1988;118(42):1510-27.
Splenomegaly Anemia
ITGA2B
Adult Agranulocytosis B-Lymphocytes Blood Platelet Disorders Females Homo sapiens Lead Poisoning Male Membrane Glycoproteins Middle Aged Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Thrombasthenia
3
(48.0%)		 12070589
 Adult lead poisoning from a herbal medicine.
Ibrahim AS, Latif AH.
Saudi Med J. 2002;23(5):591-3.
Jaundice Hemolytic anemia
Abdominal Pain Females Follow-Up Studies Health Risk Assessment Homo sapiens India Lead Poisoning Middle Aged Phytotherapy
4
(47.8%)		 14620713
 Gunshot-induced plumbism in an adult male.
Akhtar AJ, Funnye AS, Akanno J.
J Natl Med Assoc. 2003;95(10):986-90.
Diabetes mellitus Pancreatitis Hemolytic anemia
Abdominal Pain Adult Anemia, Hemolytic Chelating Agents Homo sapiens Lead Poisoning Male Time Factors
5
(47.2%)		 24348646
(3860072)
 Cholestasis and seizure due to lead toxicity: a case report.
Mokhtarifar A, Mozaffari H, Afshari R, Goshayeshi L, Akavan Rezayat K, Ghaffarzadegan K, Sheikhian M, Rajabzadeh F.
Hepat Mon. 2013;13(11):e12427.
Seizure Cholestasis Normocytic anemia
5
(47.2%)		 19565057
 Hepatic morphopathologic findings of lead poisoning in a drug addict: a case report.
Verheij J, Voortman J, van Nieuwkerk CM, Jarbandhan SV, Mulder CJ, Bloemena E.
J Gastrointestin Liver Dis. 2009;18(2):225-7.
Cholestasis Normocytic anemia
Abdominal Pain Adult Anemia Chelating Agents Chemical and Drug Induced Liver Injury Cholangitis Drug Contamination Fatty Liver Hemosiderosis Homo sapiens Lead Poisoning Liver Male Opioid-Related Disorders Protoporphyrins
7
(43.7%)		 15662640
 Severe lead poisoning in the plastics industry: a report of three cases.
Coyle P, Kosnett MJ, Hipkins K.
Am J Ind Med. 2005;47(2):172-5.
Normocytic anemia Constipation Azotemia
Abdominal Pain Homo sapiens Lead Poisoning Occupational Diseases Plastics Renal Insufficiency
7
(43.7%)		 12546173
 Pain in abdomen--do not forget lead poisoning.
Sood A, Midha V, Sood N.
Indian J Gastroenterol. 2002;21(6):225-6.
Diabetes mellitus Anemia Abdominal pain
Abdominal Pain Adult Chelating Agents Differential Diagnosis Homo sapiens Lead Poisoning Male Middle Aged
7
(43.7%)		 3931445
 Adult lead poisoning.
Zatlin GS, Senaldi EM, Bruckheim AH.
Am Fam Physician. 1985;32(4):137-43.
Anemia Abdominal pain Hyperuricemia
Adult Homo sapiens Lead Poisoning Male Middle Aged Occupational Diseases Protoporphyrins
10
(43.5%)		 16808730
 Plumbism or lead intoxication mimicking an abdominal tumor.
Dedeken P, Louw V, Vandooren AK, Verstegen G, Goossens W, Dubois B.
J Gen Intern Med. 2006;21(6):C1-3.
Ascites Anemia
Abdominal Neoplasms Chelating Agents Differential Diagnosis Females Flowers Hobbies Homo sapiens Lead Poisoning Lead Poisoning, Nervous System Middle Aged Protoporphyrins
        

Phenotype(s) retrieved from Orphanet

    Total: 0

HPO ID Term Frequency


Phenotype(s) retrieved from case reports

    Total: 77

HPO ID Term # of case reports
HP:0001903 Anemia 36
HP:0002027 Abdominal pain 24
HP:0001298 Encephalopathy 14
HP:0011848 Abdominal colic 9
HP:0001878 Hemolytic anemia 8
HP:0001250 Seizures 7
HP:0000112 Nephropathy 4
HP:0000822 Hypertension 4
HP:0002019 Constipation 4
HP:0009830 Peripheral neuropathy 4
HP:0001824 Weight loss 3
HP:0006846 Acute encephalopathy 3
HP:0012115 Hepatitis 3
HP:0000829 Hypoparathyroidism 2
HP:0000836 Hyperthyroidism 2
HP:0001287 Meningitis 2
HP:0001909 Leukemia 2
HP:0002013 Vomiting 2
HP:0002149 Hyperuricemia 2
HP:0002181 Cerebral edema 2
HP:0002758 Osteoarthritis 2
HP:0003040 Arthropathy 2
HP:0007185 Loss of consciousness 2
HP:0011458 Abdominal symptom 2
HP:0012531 Pain 2
HP:0032155 Abdominal cramps 2
HP:0100769 Synovitis 2
HP:0000238 Hydrocephalus 1
HP:0000717 Autism 1
HP:0000789 Infertility 1
HP:0000843 Hyperparathyroidism 1
HP:0000939 Osteoporosis 1
HP:0000952 Jaundice 1
HP:0000969 Edema 1
HP:0001271 Polyneuropathy 1
HP:0001369 Arthritis 1
HP:0001370 Rheumatoid arthritis 1
HP:0001894 Thrombocytosis 1
HP:0001907 Thromboembolism 1
HP:0001947 Renal tubular acidosis 1
HP:0002018 Nausea 1
HP:0002039 Anorexia 1
HP:0002133 Status epilepticus 1
HP:0002153 Hyperkalemia 1
HP:0002171 Gliosis 1
HP:0002273 Tetraparesis 1
HP:0002311 Incoordination 1
HP:0002527 Falls 1
HP:0002595 Ileus 1
HP:0002615 Hypotension 1
HP:0002625 Deep venous thrombosis 1
HP:0002652 Skeletal dysplasia 1
HP:0002748 Rickets 1
HP:0002900 Hypokalemia 1
HP:0002905 Hyperphosphatemia 1
HP:0003095 Septic arthritis 1
HP:0003470 Paralysis 1
HP:0003761 Calcinosis 1
HP:0004389 Intestinal pseudo-obstruction 1
HP:0004445 Elliptocytosis 1
HP:0004979 Metaphyseal sclerosis 1
HP:0005086 Knee osteoarthritis 1
HP:0007108 Demyelinating peripheral neuropathy 1
HP:0007352 Cerebellar calcifications 1
HP:0010550 Paraplegia 1
HP:0012384 Rhinitis 1
HP:0012486 Myelitis 1
HP:0025230 Tendonitis 1
HP:0030731 Carcinoma 1
HP:0030955 Alcoholism 1
HP:0031189 Wrist drop 1
HP:0031368 Intestinal perforation 1
HP:0100735 Hypertensive crisis 1
HP:0100753 Schizophrenia 1
HP:0100845 Anaphylactic shock 1
HP:0100959 Dense metaphyseal bands 1
HP:0200119 Acute hepatitis 1


Causative gene(s) retrieved from Orphanet

    Total: 0

Gene Symbol Gene Name Entrez Gene ID