American trypanosomiasis

A tropical disease mainly found in latin America and transmitted by triatomine insects (mostly <i>Triatoma infestans</i> and <i>Rhodnius prolixus</i> and <i>Panstrongylus megistus</i>) harboring the hemoflagellate protozoan parasite <i>Trypanosoma cruzi</i>. The disease is characterized by an acute phase which is either asymptomatic or manifest with fever, inflammation at the inoculation site (inoculation chancre or chagoma), unilateral palpebral edema called the Romaña sign (when the triatomine bite occurs near the eye), enlarged lymph nodes, and splenomegaly. The chronic phase is lifelong and development of chagasic cardiomyopathy (30%; complex arrhythmias, heart failure, and thromboembolic events), digestive (10%; megaoesophagus and megacolon), neurological (10%; stroke, peripheral neuropathy and autonomic dysfunction), or mixed alterations (10%) may be observed. These can all lead to high morbidity and mortality rates.



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Narrow down the case reports



Total: 191 (papers)

   


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)		 PMID
(PMCID)
1
(32.9%)		 31066753
 Fatal evolution of acute Chagas disease in a child from Northern Brazil: factors that determine poor prognosis.
Esper HR, Freitas VLT, Assy JGPL, Shimoda EY, Berreta OCP, Lopes MH, Franca FOS.
Rev Inst Med Trop Sao Paulo. 2019;61:e27.
Edema Hepatomegaly
Acute Disease Chagas Disease Fatal Outcome Food Parasitology Homo sapiens Infant Male Nitroimidazoles Trypanocidal Agents
1
(32.9%)		 27660581
 Chagas Cardiomyopathy in New Orleans and the Southeastern United States.
Hsu RC, Burak J, Tiwari S, Chakraborti C, Sander GE.
Ochsner J. 2016;16(3):304-8.
Hepatosplenomegaly Fever
3
(31.4%)		 15057949
 Prenatal diagnosis of congenital Chagas' disease (American trypanosomiasis).
Okumura M, Aparecida dos Santos V, Camargo ME, Schultz R, Zugaib M.
Prenat Diagn. 2004;24(3):179-81.
Anemia Myocarditis
Adult Animals Antibodies, Protozoan Brazil Chagas Disease Females Gestational Age Homo sapiens Hydrops Fetalis Immunoglobulin M Placenta Pregnancy Pregnancy Complications, Parasitic Trypanosoma cruzi
4
(29.5%)		 8913915
 Chagas' disease reactivation after heart transplantation: efficacy of allopurinol treatment.
Almeida DR, Carvalho AC, Branco JN, Pereira AP, Correa L, Vianna PV, Buffolo E, Martinez EE.
J Heart Lung Transplant. 1996;15(10):988-92.
Subcutaneous nodule Leukopenia Anorexia
Adult Chagas Cardiomyopathy Chagas Disease Homo sapiens Male Middle Aged
5
(27.8%)		 9662966
 [Hanseniasis virchowiana in Chagas cardiopathy: an autopsy report].
de Lima MA, Rodrigues Junior V, Silva-Vergara ML, Nomelini MB, Paim N, dos Santos TA, dos Santos VM.
Rev Soc Bras Med Trop. 1998;31(4):385-90.
Splenomegaly
Adult Autopsy Chagas Cardiomyopathy Fatal Outcome Homo sapiens Leprosy, Lepromatous Male Myocardium Skin
6
(27.2%)		 29525805
 Congenital Chagas disease in a Bolivian newborn in Bergamo (Italy).
Bargiggia G, Ruggeri M, Ortalli G, Gabrielli S, Rodari P, D'Antiga L, Farina C.
Infez Med. 2018;26(1):93-96.
Anemia
Bolivia Chagas Disease Females Homo sapiens Infant, Newborn Italy
6
(27.2%)		 28304254
 Clinical Trypanosoma cruzi Disease after Cardiac Transplantation in a Cynomolgus Macaque (Macaca fascicularis).
Rybak ER, Shipley S, Tatarov I, Zhang T, Sun W, Braileanu G, Burdorf L, Sievert E, Azimzadeh AM, DeTolla LJ, Pierson RN III.
Comp Med. 2016;66(6):494-498.
Weight loss Anemia
Anemia Animals Blood Transfusion Chagas Disease Females Heart Heart Transplantation Immunosuppressive Agents Macaca fascicularis Male Monkey Diseases Trypanosoma cruzi
8
(26.7%)		 9650338
 Chagas disease. First congenital case report.
Guzman-Bracho C, Lahuerta S, Velasco-Castrejon O.
Arch Med Res. 1998;29(2):195-6.
Hepatosplenomegaly
Chagas Disease Females Homo sapiens Infant, Newborn Infant, Premature, Diseases Mexico
9
(26.7%)		 24908745
 [Emerging parasitic diseases].
Weibel Galluzzo C, Wagner N, Michel Y, Jackson Y, Chappuis F.
Rev Med Suisse. 2014;10(429):1008-13.
Eosinophilia Fever
Adult Chagas Disease Communicable Diseases, Emerging Females Homo sapiens Malaysia Male Myopathy Pregnancy Pregnancy Complications, Parasitic Sarcocystosis Travel Medicine
9
(26.7%)		 21132239
 [Chagas' disease as a cause of cerebral mass in a patient with lymphoblastic leukemia in remission].
Cohen V, Ceballos V, Rodriguez N, Gonzalez C, Marciano B, Dackiewicz N, Berberian G.
Arch Argent Pediatr. 2010;108(6):134-7.
Edema Leukemia
Central Nervous System Protozoal Infections Chagas Disease Females Homo sapiens Precursor Cell Lymphoblastic Leukemia Lymphoma
        

Phenotype(s) retrieved from Orphanet

    Total: 27

HPO ID Term Frequency
HP:0000969 Edema Frequent (79-30%)
HP:0000980 Pallor Frequent (79-30%)
HP:0000988 Skin rash Frequent (79-30%)
HP:0001638 Cardiomyopathy Frequent (79-30%)
HP:0001744 Splenomegaly Frequent (79-30%)
HP:0001907 Thromboembolism Frequent (79-30%)
HP:0001945 Fever Frequent (79-30%)
HP:0002014 Diarrhea Frequent (79-30%)
HP:0002027 Abdominal pain Frequent (79-30%)
HP:0002094 Dyspnea Frequent (79-30%)
HP:0002240 Hepatomegaly Frequent (79-30%)
HP:0002315 Headache Frequent (79-30%)
HP:0002716 Lymphadenopathy Frequent (79-30%)
HP:0003326 Myalgia Frequent (79-30%)
HP:0011355 Localized skin lesion Frequent (79-30%)
HP:0011675 Arrhythmia Frequent (79-30%)
HP:0012735 Cough Frequent (79-30%)
HP:0012819 Myocarditis Frequent (79-30%)
HP:0030057 Autoimmune antibody positivity Frequent (79-30%)
HP:0100539 Periorbital edema Frequent (79-30%)
HP:0001635 Congestive heart failure Occasional (29-5%)
HP:0002251 Aganglionic megacolon Occasional (29-5%)
HP:0002571 Achalasia Occasional (29-5%)
HP:0012700 Abnormal large intestine physiology Occasional (29-5%)
HP:0000707 Abnormality of the nervous system Very rare (4-1%)
HP:0002383 Encephalitis Very rare (4-1%)
HP:0009830 Peripheral neuropathy Very rare (4-1%)


Phenotype(s) retrieved from case reports

    Total: 62

HPO ID Term # of case reports
HP:0001638 Cardiomyopathy 22
HP:0012819 Myocarditis 14
HP:0011675 Arrhythmia 7
HP:0001907 Thromboembolism 5
HP:0002721 Immunodeficiency 5
HP:0001297 Stroke 4
HP:0002571 Achalasia 4
HP:0004756 Ventricular tachycardia 4
HP:0001271 Polyneuropathy 3
HP:0001279 Syncope 3
HP:0031690 Opportunistic infection 3
HP:0100614 Myositis 3
HP:0001653 Mitral regurgitation 2
HP:0001909 Leukemia 2
HP:0001945 Fever 2
HP:0002664 Neoplasm 2
HP:0004389 Intestinal pseudo-obstruction 2
HP:0012219 Erythema nodosum 2
HP:0031003 Polyneuritis 2
HP:0000100 Nephrotic syndrome 1
HP:0000123 Nephritis 1
HP:0000225 Gingival bleeding 1
HP:0000822 Hypertension 1
HP:0000836 Hyperthyroidism 1
HP:0001433 Hepatosplenomegaly 1
HP:0001548 Overgrowth 1
HP:0001635 Congestive heart failure 1
HP:0001645 Sudden cardiac death 1
HP:0001658 Myocardial infarction 1
HP:0001678 Atrioventricular block 1
HP:0001692 Atrial arrhythmia 1
HP:0001695 Cardiac arrest 1
HP:0001701 Pericarditis 1
HP:0001903 Anemia 1
HP:0001913 Granulocytopenia 1
HP:0001962 Palpitations 1
HP:0002019 Constipation 1
HP:0002202 Pleural effusion 1
HP:0002315 Headache 1
HP:0002716 Lymphadenopathy 1
HP:0004308 Ventricular arrhythmia 1
HP:0004395 Malnutrition 1
HP:0004937 Pulmonary artery aneurysm 1
HP:0005110 Atrial fibrillation 1
HP:0005162 Left ventricular dysfunction 1
HP:0005206 Pancreatic pseudocyst 1
HP:0007209 Facial paralysis 1
HP:0010783 Erythema 1
HP:0011706 Second degree atrioventricular block 1
HP:0011712 Right bundle branch block 1
HP:0011715 Trifascicular block 1
HP:0012050 Anasarca 1
HP:0012251 ST segment elevation 1
HP:0012450 Chronic constipation 1
HP:0012490 Panniculitis 1
HP:0031002 Neuritis 1
HP:0031035 Chronic infection 1
HP:0031864 Bacteremia 1
HP:0100540 Palpebral edema 1
HP:0100584 Endocarditis 1
HP:0100633 Esophagitis 1
HP:0100658 Cellulitis 1


Causative gene(s) retrieved from Orphanet

    Total: 0

Gene Symbol Gene Name Entrez Gene ID