American trypanosomiasis

A tropical disease mainly found in latin America and transmitted by triatomine insects (mostly Triatoma infestans and Rhodnius prolixus and Panstrongylus megistus) harboring the hemoflagellate protozoan parasite Trypanosoma cruzi. The disease is characterized by an acute phase which is either asymptomatic or manifest with fever, inflammation at the inoculation site (inoculation chancre or chagoma), unilateral palpebral edema called the Romaña sign (when the triatomine bite occurs near the eye), enlarged lymph nodes, and splenomegaly. The chronic phase is lifelong and development of chagasic cardiomyopathy (30%; complex arrhythmias, heart failure, and thromboembolic events), digestive (10%; megaoesophagus and megacolon), neurological (10%; stroke, peripheral neuropathy and autonomic dysfunction), or mixed alterations (10%) may be observed. These can all lead to high morbidity and mortality rates.

Input patient's signs and symptoms

Narrow down the case reports

Total: 191 (papers)

(per page)

Matched Phenotype Gene Mutation MeSH

Rank (Similarity)	PMID (PMCID)
21 (21.6%)	21412398	[Chagas disease in Mexico. Report of two acute cases]. Salazar Schettino PM, Bucio Torres M, Cabrera Bravo M, Ruiz Hernandez AL. Gac Med Mex. 2011;147(1):63-9. [ Show abstract ] [ Hide abstract ]
		Fever Lymphadenopathy


		Acute Disease Chagas Disease Child Females Homo sapiens Male Mexico
22 (21.6%)	21973028	Trypanosoma cruzi connatal transmission in dogs with Chagas disease: experimental case report. Rodriguez-Morales O, Ballinas-Verdugo MA, Alejandre-Aguilar R, Reyes PA, Arce-Fonseca M. Vector Borne Zoonotic Dis. 2011;11(10):1365-70. [ Show abstract ] [ Hide abstract ]
		Weight loss Fever Chronic diarrhea


		Animals Antibodies, Protozoan Canis familiaris Cardiomegaly Chagas Disease Echocardiography Electrocardiography Fatal Outcome Females Fever Fluorescent Antibody Technique Lymphatic Diseases Male Pregnancy Pregnancy Complications, Parasitic Time Factors Trypanosoma cruzi
22 (21.6%)	8540804	[Small bowel bacterial overgrowth syndrome in chagasic megajejunum: report of 2 cases]. Aprile LR, Troncon LE, Meneghelli UG, de Oliveira RB. Arq Gastroenterol. 1995;32(2):71-8. [ Show abstract ] [ Hide abstract ]
		Overgrowth Malabsorption Hypocalcemia


		Adult Bacteria, Anaerobic Chagas Disease Colony Count, Microbial Females Gastrointestinal Motility Homo sapiens Intestines, Small Male Manometry Middle Aged
24 (20.8%)	21633036	A patient with erythema nodosus leprosum and Chagas cardiopathy: challenges in patient management and review of the literature. Trindade MA, Carvalho NB, Belfort EC, Pagliari C, Gakiya E, Sakai-Valente NY, Benard G, Shikanai-Yasuda MA. Am J Trop Med Hyg. 2011;84(6):973-7. [ Show abstract ] [ Hide abstract ]
		Erythema


		Adrenal Cortex Hormones Brazil Chagas Cardiomyopathy Erythema Nodosum Females Heart Diseases Homo sapiens Immunosuppressive Agents Leprostatic Agents Leprosy, Lepromatous Middle Aged
24 (20.8%)	15717098	[Erythema nodoso in reactivation of Chagas' disease after cardiac transplantation]. d'Avila SC, d'Avila AM, Pagliari C, Goncalves VM, Duarte MI. Rev Soc Bras Med Trop. 2005;38(1):61-3. [ Show abstract ] [ Hide abstract ]
		Erythema


		Adult Animals Chagas Cardiomyopathy Erythema Nodosum Females Heart Transplantation Homo sapiens Immunocompromised Host Trypanocidal Agents Trypanosoma cruzi
26 (20.5%)	27049374	A case of Chagas' disease panniculitis after kidney transplantation. Campos FP, Pansard HM, Arantes LC, Rodrigues AT, Daubermann MF, Azambuja MF, Argenta LC, Silva LA. J Bras Nefrol. 2016;38(1):127-31. [ Show abstract ] [ Hide abstract ]
		Pancytopenia Panniculitis


		Chagas Disease Females Homo sapiens Immunosuppressive Agents Kidney Transplantation Middle Aged Panniculitis Trypanosoma cruzi
26 (20.5%)	26851874	Two cases of overlap severe cutaneous adverse reactions to benznidazole treatment for asymptomatic Chagas disease in a nonendemic country. Gonzalez-Ramos J, Noguera-Morel L, Tong HY, Ramirez E, Ruiz-Bravo E, Bellon T, Cabanas R, Cachafeiro L, Herranz-Pinto P. Br J Dermatol. 2016;175(3):604-7. [ Show abstract ] [ Hide abstract ]
		Eosinophilia


		Adult Chagas Disease Drug Eruptions Edema Females Homo sapiens Male Nitroimidazoles Stevens-Johnson Syndrome Trypanocidal Agents
26 (20.5%)	16123968	Transmission of T. cruzi infection via liver transplantation to a nonreactive recipient for Chagas' disease. Barcan L, Luna C, Lunao C, Clara L, Sinagra A, Valledor A, De Rissio AM, De Rissioi AM, Gadano A, Gadanoa A, Garcia MM, de Santibanes E, Riarte A. Liver Transpl. 2005;11(9):1112-6. [ Show abstract ] [ Hide abstract ]
		Leukemia


		Adult Animals Chagas Disease Fatal Outcome Females Homo sapiens Tissue Donors Trypanosoma cruzi
26 (20.5%)	9509974	Recipients and donors of bone marrow transplants suffering from Chagas' disease: management and preemptive therapy of parasitemia. Dictar M, Sinagra A, Veron MT, Luna C, Dengra C, De Rissio A, Bayo R, Ceraso D, Segura E, Koziner B, Riarte A. Bone Marrow Transplant. 1998;21(4):391-3. [ Show abstract ] [ Hide abstract ]
		Neutropenia


		Adult Bone Marrow Transplantation Chagas Disease Females Homo sapiens Lymphoma, Non-Hodgkin Male Middle Aged Nitroimidazoles Parasitemia Transplantation, Autologous Transplantation, Homologous Trypanocidal Agents
26 (20.5%)	9216110	Tumor-like lesion due to Chagas' disease in a patient with lymphocytic leukemia. Salgado PR, Gorski AG, Aleixo AR, de Barros EO. Rev Inst Med Trop Sao Paulo. 1996;38(4):285-8. [ Show abstract ] [ Hide abstract ]
		Sinusitis Leukemia


		Animals Brain Diseases Chagas Disease Homo sapiens Male

Phenotype(s) retrieved from Orphanet

Total: 27

HPO ID	Term	Frequency
HP:0000969	Edema	Frequent (79-30%)
HP:0000980	Pallor	Frequent (79-30%)
HP:0000988	Skin rash	Frequent (79-30%)
HP:0001638	Cardiomyopathy	Frequent (79-30%)
HP:0001744	Splenomegaly	Frequent (79-30%)
HP:0001907	Thromboembolism	Frequent (79-30%)
HP:0001945	Fever	Frequent (79-30%)
HP:0002014	Diarrhea	Frequent (79-30%)
HP:0002027	Abdominal pain	Frequent (79-30%)
HP:0002094	Dyspnea	Frequent (79-30%)
HP:0002240	Hepatomegaly	Frequent (79-30%)
HP:0002315	Headache	Frequent (79-30%)
HP:0002716	Lymphadenopathy	Frequent (79-30%)
HP:0003326	Myalgia	Frequent (79-30%)
HP:0011355	Localized skin lesion	Frequent (79-30%)
HP:0011675	Arrhythmia	Frequent (79-30%)
HP:0012735	Cough	Frequent (79-30%)
HP:0012819	Myocarditis	Frequent (79-30%)
HP:0030057	Autoimmune antibody positivity	Frequent (79-30%)
HP:0100539	Periorbital edema	Frequent (79-30%)
HP:0001635	Congestive heart failure	Occasional (29-5%)
HP:0002251	Aganglionic megacolon	Occasional (29-5%)
HP:0002571	Achalasia	Occasional (29-5%)
HP:0012700	Abnormal large intestine physiology	Occasional (29-5%)
HP:0000707	Abnormality of the nervous system	Very rare (4-1%)
HP:0002383	Encephalitis	Very rare (4-1%)
HP:0009830	Peripheral neuropathy	Very rare (4-1%)

Phenotype(s) retrieved from case reports

Total: 62

HPO ID	Term	# of case reports
HP:0001638	Cardiomyopathy	22
HP:0012819	Myocarditis	14
HP:0011675	Arrhythmia	7
HP:0001907	Thromboembolism	5
HP:0002721	Immunodeficiency	5
HP:0001297	Stroke	4
HP:0002571	Achalasia	4
HP:0004756	Ventricular tachycardia	4
HP:0001271	Polyneuropathy	3
HP:0001279	Syncope	3
HP:0031690	Opportunistic infection	3
HP:0100614	Myositis	3
HP:0001653	Mitral regurgitation	2
HP:0001909	Leukemia	2
HP:0001945	Fever	2
HP:0002664	Neoplasm	2
HP:0004389	Intestinal pseudo-obstruction	2
HP:0012219	Erythema nodosum	2
HP:0031003	Polyneuritis	2
HP:0000100	Nephrotic syndrome	1
HP:0000123	Nephritis	1
HP:0000225	Gingival bleeding	1
HP:0000822	Hypertension	1
HP:0000836	Hyperthyroidism	1
HP:0001433	Hepatosplenomegaly	1
HP:0001548	Overgrowth	1
HP:0001635	Congestive heart failure	1
HP:0001645	Sudden cardiac death	1
HP:0001658	Myocardial infarction	1
HP:0001678	Atrioventricular block	1
HP:0001692	Atrial arrhythmia	1
HP:0001695	Cardiac arrest	1
HP:0001701	Pericarditis	1
HP:0001903	Anemia	1
HP:0001913	Granulocytopenia	1
HP:0001962	Palpitations	1
HP:0002019	Constipation	1
HP:0002202	Pleural effusion	1
HP:0002315	Headache	1
HP:0002716	Lymphadenopathy	1
HP:0004308	Ventricular arrhythmia	1
HP:0004395	Malnutrition	1
HP:0004937	Pulmonary artery aneurysm	1
HP:0005110	Atrial fibrillation	1
HP:0005162	Left ventricular dysfunction	1
HP:0005206	Pancreatic pseudocyst	1
HP:0007209	Facial paralysis	1
HP:0010783	Erythema	1
HP:0011706	Second degree atrioventricular block	1
HP:0011712	Right bundle branch block	1
HP:0011715	Trifascicular block	1
HP:0012050	Anasarca	1
HP:0012251	ST segment elevation	1
HP:0012450	Chronic constipation	1
HP:0012490	Panniculitis	1
HP:0031002	Neuritis	1
HP:0031035	Chronic infection	1
HP:0031864	Bacteremia	1
HP:0100540	Palpebral edema	1
HP:0100584	Endocarditis	1
HP:0100633	Esophagitis	1
HP:0100658	Cellulitis	1

Causative gene(s) retrieved from Orphanet

Total: 0

Gene Symbol	Gene Name	Entrez Gene ID