Clear cell adenocarcinoma of the ovary

Clear cell adenocarcinoma of ovary is a rare, malignant, epithelilal ovarian neoplasm, composed of clear, eosinophilic and hobnail cells displaying variable degrees of tubulocystic, papillary and solid histological patterns, macroscopically appearing as a typically unilateral mass in the ovary which ranges from solid to cystic. Patients are often diagnosed in early stages and usually present with pelvic pain and pressure, an abdominal mass and/or gastrointestinal problems, such as early satiety or bloating. Association with Lynch syndrome has been reported.



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Total: 30 (papers)

   


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)		 PMID
(PMCID)
1
(4.0%)		 29979406
(6076063)
 Synchronous occurrence of primary right ovarian endometrioid adenocarcinoma and primary left ovarian clear cell adenocarcinoma: A case report.
Zhao LJ, Wang P, He Y.
Medicine (Baltimore). 2018;97(27):e11330.
Abdominal pain
Adenocarcinoma, Clear Cell Antineoplastic Agents Carcinoma, Endometrioid Combined Modality Therapy Females Homo sapiens Hysterectomy Immunohistochemistry Middle Aged Mucinous Adenocarcinoma Neoplasms, Multiple Primary Ovary
1
(4.0%)		 29933751
(6015461)
 Alpha-fetoprotein-producing ovarian clear cell adenocarcinoma with fetal gut differentiation: a rare case report and literature review.
Chao WT, Liu CH, Lai CR, Chen YJ, Chuang CM, Wang PH.
J Ovarian Res. 2018;11(1):52.
Ovarian carcinoma
AFP GPC3 HNF1B KRT7 TNFRSF8
Adenocarcinoma, Clear Cell Biomarkers, Tumor Females Gene Expression Regulation, Neoplastic Glypican Homo sapiens Immunohistochemistry Middle Aged Neoplasm Proteins alpha-Fetoproteins
1
(4.0%)		 29551085
 Ovarian Clear Cell Adenofibroma of Low Malignant Potential Developing Into Clear Cell Adenocarcinoma.
Yin Z, Peters S, Chokshi R, Heller D.
Int J Surg Pathol. 2018;26(6):578-580.
Endometriosis
Adenocarcinoma, Clear Cell Adenofibroma Colectomy Females Gastrointestinal Hemorrhage Homo sapiens Incidental Findings Middle Aged Neoplastic Cell Transformation Ovary Salpingo-oophorectomy Sigmoid Neoplasms X-Ray Computed Tomography
1
(4.0%)		 29184869
(5694735)
 Skin metastases in ovarian clear cell adenocarcinoma: a case report and a review of the literature.
Nam G, Lim YM, Cho MS, Lee J, Kim YH.
Obstet Gynecol Sci. 2017;60(6):593-597.
Carcinoma
1
(4.0%)		 28133347
 [Ovarian Cancer Rupture Causing Acute Abdomen That Required Emergency Surgery - A Case Report].
Yamakoshi Y, Aomatsu N, Yamasaki N, Nobori C, Kurihara S, Wang E, Nagashima D, Hirakawa T, Iwauchi T, Morimoto J, Tei S, Nakazawa K, Uchima Y, Takeuchi K.
Gan To Kagaku Ryoho. 2016;43(12):2438-2440.
Ascites
Abdomen, Acute Antineoplastic Combined Chemotherapy Protocols Females Homo sapiens Middle Aged Ovariectomy Rupture, Spontaneous X-Ray Computed Tomography
1
(4.0%)		 27833758
(5094302)
 Rare and challenging case of stroke as a manifestation of non bacterial thrombotic endocarditis in an underlying ovarian clear cell carcinoma.
Kanthasamy V, Natarajan I.
JRSM Open. 2016;7(11):2054270416669304.
Stroke
1
(4.0%)		 27660815
(5021916)
 Vesical clear cell adenocarcinoma arising from endometriosis: A mullerian tumor, indistinguishable from ovarian clear cell adenocarcinoma.
Miller EM, Sun Y, Richardson I, Frimer M.
Gynecol Oncol Rep. 2016;18:8-10.
Endometriosis
1
(4.0%)		 26622893
 Optimal cytoreductive surgery for underlying ovarian cancer associated with deep venous thrombosis without placement of inferior vena cava filter: A case report and literature review.
Shen H, Shang J, Niu G, Liu J, You Z, He S.
Oncol Lett. 2015;10(4):2579-2583.
Pulmonary embolism
1
(4.0%)		 26197755
 [A Case of Pneumocystis Pneumonia during Chemotherapy for Recurrent Ovarian Cancer].
Shiomi M, Okubo R, Miyagi K, Murakami J, Kuwaduru T, Uragami K, Nakagawa M, Yoshioka E, Tsuruta T, Tashima R, Hori K, Ito K.
Gan To Kagaku Ryoho. 2015;42(7):879-81.
Pneumonia
Adenocarcinoma, Clear Cell Antibiotics, Antineoplastic Females Homo sapiens Middle Aged Steroids
1
(4.0%)		 26082939
(4458747)
 Non-diethylstilbestrol exposed vaginal clear cell adenocarcinoma has a common molecular profile with ovarian clear cell adenocarcinoma: A case report.
Ikeda Y, Oda K, Aburatani H, Kawana K, Osuga Y, Fujii T.
Gynecol Oncol Rep. 2014;10:49-52.
Vaginal clear cell adenocarcinoma
PIK3CA
        

Phenotype(s) retrieved from Orphanet

    Total: 0

HPO ID Term Frequency


Phenotype(s) retrieved from case reports

    Total: 10

HPO ID Term # of case reports
HP:0030127 Endometriosis 4
HP:0003072 Hypercalcemia 2
HP:0001289 Confusion 1
HP:0001297 Stroke 1
HP:0002019 Constipation 1
HP:0002027 Abdominal pain 1
HP:0002586 Peritonitis 1
HP:0012735 Cough 1
HP:0031521 Vaginal clear cell adenocarcinoma 1
HP:0100584 Endocarditis 1


Causative gene(s) retrieved from Orphanet

    Total: 0

Gene Symbol Gene Name Entrez Gene ID