Serotonin syndrome

Serotoninergic syndrome is characterised by an excess of serotonin in the central nervous system, associated with the use of various agents, including selective serotonin reuptake inhibitors (SSRIs).



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Narrow down the case reports



Total: 285 (papers)

   


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)		 PMID
(PMCID)
1
(42.7%)		 30090822
(6078474)
 Hyperthermia and Rigidity Following Overdose of an Unknown Drug; A Case Report and Literature Review.
Dean-Paccagnella R, Creed M, Kakollu M, Gopala Pillai SK.
Bull Emerg Trauma. 2018;6(3):249-252.
Trismus
1
(42.7%)		 22719217
(3377381)
 Serotonin syndrome with escitolapram and concomitant use of cocaine: a case report.
Malik HU, Kumar K.
Clin Med Insights Case Rep. 2012;5:81-5.
Trismus
1
(42.7%)		 17503244
 Urinary serotonin level is associated with serotonin syndrome after moclobemide, sertraline, and citalopram overdose.
Brvar M, Stajer D, Kozelj G, Osredkar J, Mozina M, Bunc M.
Clin Toxicol (Phila). 2007;45(5):458-60.
Trismus
Adult Antidepressive Agents Drug Overdose Females Homo sapiens Hydroxyindoleacetic Acid Monoamine Oxidase Inhibitors Serotonin Syndrome Serotonin Uptake Inhibitors
1
(42.7%)		 12555608
 [Serotonin syndrome--several cases of this often overlooked diagnosis].
Hojer J, Personne M, Skagius AS, Hansson O.
Tidsskr Nor Laegeforen. 2002;122(17):1660-3.
Trismus
Adult Antidepressive Agents Differential Diagnosis Drug Overdose Females Homo sapiens Male Monoamine Oxidase Inhibitors Serotonin Syndrome
1
(42.7%)		 12082784
 [Serotonin syndrome. Several cases of this often overlooked diagnosis].
Hojer J, Personne M, Skagius AS, Hansson O.
Lakartidningen. 2002;99(18):2054-5, 2058-60.
Trismus
Adult Antidepressive Agents Differential Diagnosis Drug Overdose Females Homo sapiens Male Monoamine Oxidase Inhibitors Serotonin Syndrome
6
(28.5%)		 24614188
 Serotonin syndrome after therapeutic hypothermia for cardiac arrest: a case series.
Fugate JE, White RD, Rabinstein AA.
Resuscitation. 2014;85(6):774-7.
Tremor Ankle clonus
Adult Cardiac Arrest Homo sapiens Hypothermia, Induced Male Middle Aged Retrospective Studies Serotonin Syndrome
6
(28.5%)		 10512094
 Postoperative delirium indicating an adverse drug interaction involving the selective serotonin reuptake inhibitor, paroxetine?
Stanford BJ, Stanford SC.
J Psychopharmacol. 1999;13(3):313-7.
Agitation Ankle clonus
CYP2D6
Analgesics, Opioid Delirium Females Homo sapiens Middle Aged Parathyroidectomy Postoperative Complications Serotonin Uptake Inhibitors Substance Withdrawal Syndrome
8
(27.7%)		 26945397
(4782881)
 A Case Report of Probable Paliperidone ER-Induced Serotonin Syndrome in a 17-Year-Old Taiwanese Female With New Onset Psychosis.
Yang CH, Juang KD, Chou PH, Chan CH.
Medicine (Baltimore). 2016;95(9):e2930.
Psychosis Drooling
Females Homo sapiens Serotonin 5-HT2 Receptor Antagonists Serotonin Syndrome
9
(26.3%)		 21147393
 Serotonin syndrome induced by tramadol intoxication in an 8-month-old infant.
Marechal C, Honorat R, Claudet I.
Pediatr Neurol. 2011;44(1):72-4.
Epistaxis
Analgesics, Opioid Epistaxis Females Fever Hemodynamics Homo sapiens Infant Seizures Serotonin Syndrome
9
(26.3%)		 17364639
 Dyskinesias associated with atomoxetine in combination with other psychoactive drugs.
Bond GR, Garro AC, Gilbert DL.
Clin Toxicol (Phila). 2007;45(2):182-5.
Psychosis Facial tics
CYP2D6
Child Combination Drug Therapy Dyskinesia, Drug-Induced Females Homo sapiens Male Propylamines Psychotropic Drugs
        

Phenotype(s) retrieved from Orphanet

    Total: 0

HPO ID Term Frequency


Phenotype(s) retrieved from case reports

    Total: 87

HPO ID Term # of case reports
HP:0001250 Seizures 14
HP:0001337 Tremor 14
HP:0000713 Agitation 13
HP:0001336 Myoclonus 12
HP:0001347 Hyperreflexia 11
HP:0001649 Tachycardia 11
HP:0001945 Fever 11
HP:0001289 Confusion 10
HP:0002169 Clonus 9
HP:0003201 Rhabdomyolysis 9
HP:0001298 Encephalopathy 7
HP:0031258 Delirium 7
HP:0000752 Hyperactivity 6
HP:0001297 Stroke 6
HP:0002047 Malignant hyperthermia 6
HP:0000822 Hypertension 5
HP:0002018 Nausea 5
HP:0002063 Rigidity 5
HP:0025144 Shivering 5
HP:0000711 Restlessness 4
HP:0000709 Psychosis 3
HP:0001251 Ataxia 3
HP:0005521 Disseminated intravascular coagulation 3
HP:0011499 Mydriasis 3
HP:0100785 Insomnia 3
HP:0001257 Spasticity 2
HP:0001276 Hypertonia 2
HP:0001695 Cardiac arrest 2
HP:0002014 Diarrhea 2
HP:0002045 Hypothermia 2
HP:0002076 Migraine 2
HP:0002315 Headache 2
HP:0002789 Tachypnea 2
HP:0002902 Hyponatremia 2
HP:0012115 Hepatitis 2
HP:0031284 Flushing 2
HP:0000622 Blurred vision 1
HP:0000717 Autism 1
HP:0000726 Dementia 1
HP:0000739 Anxiety 1
HP:0000975 Hyperhidrosis 1
HP:0001138 Optic neuropathy 1
HP:0001254 Lethargy 1
HP:0001300 Parkinsonism 1
HP:0001332 Dystonia 1
HP:0001394 Cirrhosis 1
HP:0001638 Cardiomyopathy 1
HP:0001942 Metabolic acidosis 1
HP:0001944 Dehydration 1
HP:0002013 Vomiting 1
HP:0002017 Nausea and vomiting 1
HP:0002090 Pneumonia 1
HP:0002093 Respiratory insufficiency 1
HP:0002099 Asthma 1
HP:0002104 Apnea 1
HP:0002133 Status epilepticus 1
HP:0002204 Pulmonary embolism 1
HP:0002300 Mutism 1
HP:0002317 Unsteady gait 1
HP:0002367 Visual hallucinations 1
HP:0002488 Acute leukemia 1
HP:0002527 Falls 1
HP:0002615 Hypotension 1
HP:0002721 Immunodeficiency 1
HP:0002878 Respiratory failure 1
HP:0003128 Lactic acidosis 1
HP:0004756 Ventricular tachycardia 1
HP:0007302 Bipolar affective disorder 1
HP:0012043 Pendular nystagmus 1
HP:0012282 Morbilliform rash 1
HP:0012395 Seasonal allergy 1
HP:0012532 Chronic pain 1
HP:0030149 Cardiogenic shock 1
HP:0030833 Neck pain 1
HP:0031218 Inappropriate antidiuretic hormone secretion 1
HP:0031546 Cardiac conduction abnormality 1
HP:0031943 Akathisia 1
HP:0040192 APUdoma 1
HP:0100021 Cerebral palsy 1
HP:0100315 Lewy bodies 1
HP:0100584 Endocarditis 1
HP:0100598 Pulmonary edema 1
HP:0100645 Cystocele 1
HP:0100665 Angioedema 1
HP:0100735 Hypertensive crisis 1
HP:0100806 Sepsis 1
HP:0200123 Chronic hepatitis 1


Causative gene(s) retrieved from Orphanet

    Total: 0

Gene Symbol Gene Name Entrez Gene ID