Leprosy

A chronic infectious disease affecting primarily the skin and peripheral nervous system.



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Total: 743 (papers)

  


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)
PMID
(PMCID)
1
(57.4%)
15654479
Dapsone hypersensitivity syndrome in an adolescent during treatment during of leprosy.
Bucaretchi F, Vicente DC, Pereira RM, Tresoldi AT.
Rev Inst Med Trop Sao Paulo. 2004;46(6):331-4.
Jaundice Edema Anemia Generalized lymphadenopathy
Child Combination Drug Therapy Drug Allergy Females Homo sapiens Leprostatic Agents Leprosy Syndrome
2
(54.2%)
8792511
Dapsone in rheumatoid arthritis.
Chang DJ, Lamothe M, Stevens RM, Sigal LH.
Semin Arthritis Rheum. 1996;25(6):390-403.
Proteinuria Jaundice Hemolytic anemia
Anti-Inflammatory Agents, Non-Steroidal Antirheumatic Agents Females Homo sapiens Male Middle Aged Rheumatoid Arthritis
3
(52.7%)
18567421
Corticosteroid pulse therapy for leprosy complicated by a severe type 1 reaction.
Lu PH, Lin JY, Tsai YL, Kuan YZ.
Chang Gung Med J. 2008;31(2):201-6.
Ascites Normocytic anemia Fever Hepatitis
Adult Delayed Hypersensitivity Females Hepatitis Homo sapiens Leprosy, Lepromatous Optic Neuritis
4
(46.5%)
19778310
Dapsone hypersensitivity syndrome with circulating 190-kDa and 230-kDa autoantibodies.
Chun JS, Yun SJ, Kim SJ, Lee SC, Won YH, Lee JB.
Clin Exp Dermatol. 2009;34(8):e798-801.
Jaundice Purpura Fever Lymphadenopathy
Adult Autoantibodies Dermatologic Agents Drug Eruptions Females Homo sapiens Hypersensitivity Syndrome Vasculitis
5
(45.7%)
30697428
The mystery of 'saturation gap': a case of dapsone-induced methaemoglobinemia in a pregnant mother with leprosy.
Tang ASO, Yeo ST, Teh YC, Kho WM, Chew LP, Muniandy P.
Oxf Med Case Reports. 2019;2019(1):omy111.
Cyanosis Fever Methemoglobinemia
6
(45.6%)
21410951
(3068105)
Dapsone-induced agranulocytosis leading to perianal abscess and death: a case report.
Kobe Y, Setoguchi D, Kitamura N.
J Med Case Rep. 2011;5:107.
Anemia Fever Perianal abscess
7
(44.2%)
28944149
A case of leprosy, erythema nodosum leprosum, and hemophagocytic syndrome: A continuum of manifestations of same agent-host interactions.
Panda PK, Prajapati R, Kumar A, Jana M, Immanuel P, Tanwar P, Wig N.
Intractable Rare Dis Res. 2017;6(3):230-233.
Hepatosplenomegaly Fever Hemophagocytosis
7
(44.2%)
23130233
(3481807)
An unusual case of dapsone syndrome.
Grace M.
Indian Dermatol Online J. 2011;2(2):88-90.
Hepatosplenomegaly Pancytopenia Fever
9
(43.5%)
28937434
Th17 Response of Borderline-Lepromatous Leprosy Inhibits Rash Manifestation of Dapsone Hypersensitivity Syndrome: Case Report.
de Nardo Vanzela T, Bernardes Filho F, Wambier CG, Faria FM, Foss NT, Frade MAC.
Am J Dermatopathol. 2018;40(3):205-208.
Jaundice Eosinophilia Hepatomegaly
IFNG IL10 IL17A IL1B IL4 ISYNA1 NELFCD TGFB1 TNF
Drug Hypersensitivity Syndrome Homo sapiens Leprostatic Agents Male Th17 Cells Young Adult
10
(42.9%)
26591847
Unusual Presentation of Necrotic Erythema Nodosum Leprosum on Scalp: A Case Report.
Barman KD, Madan A, Garg VK, Goel K, Khurana N.
Indian J Lepr. 2015;87(1):23-6.
Anemia Erythema
MLLT1
Erythema Nodosum Homo sapiens Leprosy, Lepromatous Male Middle Aged Mycobacterium leprae Necrosis
        

Phenotype(s) retrieved from Orphanet

    Total: 0

HPO ID Term Frequency


Phenotype(s) retrieved from case reports

    Total: 204

HPO ID Term # of case reports
HP:0012219 Erythema nodosum 79
HP:0025615 Abscess 27
HP:0032252 Granuloma 23
HP:0002721 Immunodeficiency 17
HP:0010783 Erythema 16
HP:0031002 Neuritis 16
HP:0009830 Peripheral neuropathy 15
HP:0001945 Fever 11
HP:0200034 Papule 11
HP:0001370 Rheumatoid arthritis 10
HP:0002860 Squamous cell carcinoma 10
HP:0000099 Glomerulonephritis 8
HP:0002716 Lymphadenopathy 8
HP:0002835 Aspiration 8
HP:0003470 Paralysis 8
HP:0012115 Hepatitis 8
HP:0000819 Diabetes mellitus 7
HP:0001369 Arthritis 7
HP:0002955 Granulomatosis 7
HP:0012234 Agranulocytosis 7
HP:0002664 Neoplasm 6
HP:0002840 Lymphadenitis 6
HP:0003072 Hypercalcemia 6
HP:0030731 Carcinoma 6
HP:0000618 Blindness 5
HP:0000969 Edema 5
HP:0001045 Vitiligo 5
HP:0002090 Pneumonia 5
HP:0012733 Macule 5
HP:0000836 Hyperthyroidism 4
HP:0001019 Erythroderma 4
HP:0001482 Subcutaneous nodule 4
HP:0002315 Headache 4
HP:0032163 Molluscum contagiosum 4
HP:0100699 Scarring 4
HP:0200036 Skin nodule 4
HP:0000488 Retinopathy 3
HP:0000491 Keratitis 3
HP:0000952 Jaundice 3
HP:0000999 Pyoderma 3
HP:0001101 Iritis 3
HP:0001271 Polyneuropathy 3
HP:0001289 Confusion 3
HP:0001635 Congestive heart failure 3
HP:0002018 Nausea 3
HP:0002027 Abdominal pain 3
HP:0002625 Deep venous thrombosis 3
HP:0002671 Basal cell carcinoma 3
HP:0008940 Generalized lymphadenopathy 3
HP:0025474 Erythematous plaque 3
HP:0025475 Erythematous macule 3
HP:0032026 Anetoderma 3
HP:0000501 Glaucoma 2
HP:0000961 Cyanosis 2
HP:0000988 Skin rash 2
HP:0001050 Plethora 2
HP:0001059 Pterygium 2
HP:0001089 Iris atrophy 2
HP:0001178 Ulnar claw 2
HP:0001297 Stroke 2
HP:0001806 Onycholysis 2
HP:0001909 Leukemia 2
HP:0002013 Vomiting 2
HP:0002527 Falls 2
HP:0002580 Volvulus 2
HP:0003040 Arthropathy 2
HP:0007209 Facial paralysis 2
HP:0007957 Corneal opacity 2
HP:0010562 Keloids 2
HP:0012032 Lipoma 2
HP:0012119 Methemoglobinemia 2
HP:0012393 Allergy 2
HP:0012735 Cough 2
HP:0020073 Hypopigmented macule 2
HP:0100532 Scleritis 2
HP:0100614 Myositis 2
HP:0100658 Cellulitis 2
HP:0100665 Angioedema 2
HP:0100727 Histiocytosis 2
HP:0100758 Gangrene 2
HP:0100769 Synovitis 2
HP:0100796 Orchitis 2
HP:0100825 Cheilitis 2
HP:0200042 Skin ulcer 2
HP:0200119 Acute hepatitis 2
HP:0430025 Bilateral facial palsy 2
HP:0000027 Azoospermia 1
HP:0000093 Proteinuria 1
HP:0000100 Nephrotic syndrome 1
HP:0000112 Nephropathy 1
HP:0000123 Nephritis 1
HP:0000135 Hypogonadism 1
HP:0000282 Facial edema 1
HP:0000421 Epistaxis 1
HP:0000505 Visual impairment 1
HP:0000509 Conjunctivitis 1
HP:0000559 Corneal scarring 1
HP:0000572 Visual loss 1
HP:0000616 Miosis 1
HP:0000656 Ectropion 1
HP:0000763 Sensory neuropathy 1
HP:0000822 Hypertension 1
HP:0000853 Goiter 1
HP:0000939 Osteoporosis 1
HP:0000958 Dry skin 1
HP:0000964 Eczema 1
HP:0000966 Hypohidrosis 1
HP:0000979 Purpura 1
HP:0001022 Albinism 1
HP:0001025 Urticaria 1
HP:0001047 Atopic dermatitis 1
HP:0001065 Striae distensae 1
HP:0001067 Neurofibromas 1
HP:0001075 Atrophic scars 1
HP:0001250 Seizures 1
HP:0001287 Meningitis 1
HP:0001349 Facial diplegia 1
HP:0001433 Hepatosplenomegaly 1
HP:0001618 Dysphonia 1
HP:0001645 Sudden cardiac death 1
HP:0001741 Phimosis 1
HP:0001742 Nasal obstruction 1
HP:0001873 Thrombocytopenia 1
HP:0001876 Pancytopenia 1
HP:0001878 Hemolytic anemia 1
HP:0001880 Eosinophilia 1
HP:0001882 Leukopenia 1
HP:0001903 Anemia 1
HP:0001919 Acute kidney injury 1
HP:0001970 Tubulointerstitial nephritis 1
HP:0002014 Diarrhea 1
HP:0002039 Anorexia 1
HP:0002046 Heat intolerance 1
HP:0002094 Dyspnea 1
HP:0002102 Pleuritis 1
HP:0002113 Pulmonary infiltrates 1
HP:0002196 Myelopathy 1
HP:0002204 Pulmonary embolism 1
HP:0002240 Hepatomegaly 1
HP:0002244 Abnormality of the small intestine 1
HP:0002257 Chronic rhinitis 1
HP:0002414 Spina bifida 1
HP:0002583 Colitis 1
HP:0002797 Osteolysis 1
HP:0002861 Melanoma 1
HP:0003076 Glycosuria 1
HP:0003265 Neonatal hyperbilirubinemia 1
HP:0003418 Back pain 1
HP:0003651 Foam cells 1
HP:0004326 Cachexia 1
HP:0004395 Malnutrition 1
HP:0004936 Venous thrombosis 1
HP:0004942 Aortic aneurysm 1
HP:0005387 Combined immunodeficiency 1
HP:0005523 Lymphoproliferative disorder 1
HP:0007108 Demyelinating peripheral neuropathy 1
HP:0007141 Sensorimotor neuropathy 1
HP:0008392 Subungual hyperkeratosis 1
HP:0008682 Acute tubular necrosis 1
HP:0011110 Tonsillitis 1
HP:0011469 Nasal regurgitation 1
HP:0011499 Mydriasis 1
HP:0011675 Arrhythmia 1
HP:0011947 Respiratory tract infection 1
HP:0012058 Nodular melanoma 1
HP:0012062 Bone cyst 1
HP:0012074 Tonic pupil 1
HP:0012125 Prostate cancer 1
HP:0012156 Hemophagocytosis 1
HP:0012315 Histiocytoma 1
HP:0012344 Morphea 1
HP:0012378 Fatigue 1
HP:0012384 Rhinitis 1
HP:0012399 Pressure ulcer 1
HP:0012531 Pain 1
HP:0012532 Chronic pain 1
HP:0012534 Dysesthesia 1
HP:0012645 Enlarged peripheral nerve 1
HP:0012804 Corneal ulceration 1
HP:0012819 Myocarditis 1
HP:0020082 Heinz bodies 1
HP:0025084 Folliculitis 1
HP:0025095 Sneeze 1
HP:0025142 Constitutional symptom 1
HP:0030350 Erythematous papule 1
HP:0030430 Neuroma 1
HP:0030955 Alcoholism 1
HP:0031003 Polyneuritis 1
HP:0031009 Ainhum 1
HP:0031018 Eccrine syringofibroadenoma 1
HP:0031035 Chronic infection 1
HP:0031245 Productive cough 1
HP:0031417 Rhinorrhea 1
HP:0031525 Keratoacanthoma 1
HP:0031615 Hypopyon 1
HP:0032018 Multiple mononeuropathy 1
HP:0032118 Retinitis 1
HP:0032282 Contact dermatitis 1
HP:0040078 Axonal degeneration 1
HP:0100279 Ulcerative colitis 1
HP:0100653 Optic neuritis 1
HP:0100726 Kaposi's sarcoma 1
HP:0100806 Sepsis 1
HP:0200123 Chronic hepatitis 1


Causative gene(s) retrieved from Orphanet

    Total: 0

Gene Symbol Gene Name Entrez Gene ID