Sheehan syndrome

Sheehan syndrome is a rare, acquired, pituitary hormone deficiency disorder resulting from pituitary necrosis following peri- or postpartum hemorrhage characterized by various symptoms depending on resulting hormone decrease (e.g. failure or difficulty with lactation, oligo- or amenorrhea, hot flashes, decreased libido, weakness, fatigue, anorexia, nausea, vomiting, hypoglycemia, hyponatremia, dizziness, decreased muscle mass, adrenal crisis). Secondary hypothyroidism and secondary adrenal insufficiency may also be presenting signs.



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Narrow down the case reports



Total: 31 (papers)

   


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)		 PMID
(PMCID)
1
(17.5%)		 19367010
 Acute renal failure in a patient with Sheehan syndrome and rhabdomyolysis.
Soltani P, Rezvanfar MR, Pirasteh S.
Iran J Kidney Dis. 2008;2(1):50-2.
Rhabdomyolysis
Females Homo sapiens Hypopituitarism Middle Aged Renal Dialysis Rhabdomyolysis
2
(4.0%)		 30116682
(6089698)
 Refractory Hypoglycemia and Seizures as the Initial Presenting Manifestation of Empty Sella Syndrome.
Sethuraman VK, Viswanathan S, Aghoram R.
Cureus. 2018;10(6):e2803.
Hypothyroidism
INS
2
(4.0%)		 28819576
(5551559)
 Pitfall in the Diagnosis of Diabetes Insipidus and Pregnancy.
Sum M, Fleischer JB, Khandji AG, Wardlaw SL.
Case Rep Obstet Gynecol. 2017;2017:7879038.
Polyuria
2
(4.0%)		 28565814
(5443209)
 Refractory hypotension induced by Sheehan syndrome with pituitary crisis: A case report.
Liang L, Liu JB, Chen FQ, Zhao J, Zhang XL.
Exp Ther Med. 2017;13(5):2097-2101.
Cardiomyopathy
2
(4.0%)		 28129900
 [Atypical and rare cardiac revelation about Sheehan's syndrome: A report of three cases].
Bouznad N, Mghari GE, Hattaoui ME, Ansari NE.
Ann Cardiol Angeiol (Paris). 2017;66(4):239-242.
Hypogonadism
Adult Females Heart Diseases Homo sapiens Hypopituitarism Middle Aged
2
(4.0%)		 25223643
 Sheehan syndrome: acute presentation with severe headache.
Hale B, Habib AS.
Int J Obstet Anesth. 2014;23(4):383-6.
Edema
Adult Differential Diagnosis Electrolytes Females Headache Homo sapiens Hypopituitarism Magnetic Resonance Imaging Pituitary Function Tests Placenta, Retained Postpartum Hemorrhage Postpartum Period Pregnancy
2
(4.0%)		 25100393
 Long-standing undiagnosed sheehan syndrome presenting as polymorphic and monomorphic ventricular tachycardia: a case series of 2 patients.
Masood MQ, Ali SA.
Endocr Pract. 2014;20(11):e211-4.
Seizure
Electrocardiography Females Homo sapiens Hypopituitarism Tachycardia, Ventricular
2
(4.0%)		 24842349
 Recurrent hypoglycaemia: a delayed presentation of Sheehan syndrome.
Kumar N, Singh P, Kumar J, Dhanwal DK.
BMJ Case Rep. 2014;2014:.
Agalactia
Blood Chemical Analysis Blood Glucose Combination Drug Therapy Delayed Diagnosis Differential Diagnosis Females Follow-Up Studies Health Risk Assessment Homo sapiens Hypoglycemia Hypopituitarism Magnetic Resonance Imaging Middle Aged Severity of Illness Index Sleep Stages
2
(4.0%)		 22138080
 Repairing a "broken heart" with hormone replacement therapy: case report of cardiogenic shock due to undiagnosed pituitary insufficiency.
Bao SS, Fisher SJ.
Endocr Pract. 2012;18(2):e26-31.
Adrenal insufficiency
ERBB2
Adult Combination Drug Therapy Confusion Delayed Diagnosis Females Glucocorticoids Homo sapiens Hypopituitarism Hypotension Severity of Illness Index Shock, Cardiogenic
2
(4.0%)		 21247847
 Panhypopituitarism secondary to a macroprolactinoma manifesting with pancytopenia: case report and literature review.
Holmes GI, Shepherd P, Walker JD.
Endocr Pract. 2011;17(2):e32-6.
Pancytopenia
PRL
Homo sapiens Hypopituitarism Male Middle Aged Pancytopenia Prolactinoma
        

Phenotype(s) retrieved from Orphanet

    Total: 49

HPO ID Term Frequency
HP:0000871 Panhypopituitarism Very frequent (99-80%)
HP:0000876 Oligomenorrhea Very frequent (99-80%)
HP:0008163 Decreased circulating cortisol level Very frequent (99-80%)
HP:0008240 Secondary growth hormone deficiency Very frequent (99-80%)
HP:0011735 Adrenocorticotropin deficient adrenal insufficiency Very frequent (99-80%)
HP:0011748 Adrenocorticotropic hormone deficiency Very frequent (99-80%)
HP:0012432 Chronic fatigue Very frequent (99-80%)
HP:0000141 Amenorrhea Frequent (79-30%)
HP:0000622 Blurred vision Frequent (79-30%)
HP:0000802 Impotence Frequent (79-30%)
HP:0000958 Dry skin Frequent (79-30%)
HP:0000980 Pallor Frequent (79-30%)
HP:0001278 Orthostatic hypotension Frequent (79-30%)
HP:0001895 Normochromic anemia Frequent (79-30%)
HP:0001943 Hypoglycemia Frequent (79-30%)
HP:0002018 Nausea Frequent (79-30%)
HP:0002215 Sparse axillary hair Frequent (79-30%)
HP:0002225 Sparse pubic hair Frequent (79-30%)
HP:0002315 Headache Frequent (79-30%)
HP:0003158 Hyposthenuria Frequent (79-30%)
HP:0003187 Breast hypoplasia Frequent (79-30%)
HP:0007987 Progressive visual field defects Frequent (79-30%)
HP:0008202 Prolactin deficiency Frequent (79-30%)
HP:0008213 Gonadotropin deficiency Frequent (79-30%)
HP:0008214 Decreased serum estradiol Frequent (79-30%)
HP:0008245 Pituitary hypothyroidism Frequent (79-30%)
HP:0011734 Central adrenal insufficiency Frequent (79-30%)
HP:0012504 Abnormal size of pituitary gland Frequent (79-30%)
HP:0030016 Dyspareunia Frequent (79-30%)
HP:0030018 Decreased female libido Frequent (79-30%)
HP:0000407 Sensorineural hearing impairment Occasional (29-5%)
HP:0000651 Diplopia Occasional (29-5%)
HP:0000872 Hashimoto thyroiditis Occasional (29-5%)
HP:0001324 Muscle weakness Occasional (29-5%)
HP:0001513 Obesity Occasional (29-5%)
HP:0001662 Bradycardia Occasional (29-5%)
HP:0001962 Palpitations Occasional (29-5%)
HP:0002019 Constipation Occasional (29-5%)
HP:0002321 Vertigo Occasional (29-5%)
HP:0002829 Arthralgia Occasional (29-5%)
HP:0002902 Hyponatremia Occasional (29-5%)
HP:0003493 Antinuclear antibody positivity Occasional (29-5%)
HP:0004396 Poor appetite Occasional (29-5%)
HP:0007041 Chronic lymphocytic meningitis Occasional (29-5%)
HP:0025143 Chills Occasional (29-5%)
HP:0030907 Thunderclap headache Occasional (29-5%)
HP:0000709 Psychosis Very rare (4-1%)
HP:0000863 Central diabetes insipidus Very rare (4-1%)
HP:0001259 Coma Very rare (4-1%)


Phenotype(s) retrieved from case reports

    Total: 24

HPO ID Term # of case reports
HP:0040075 Hypopituitarism 5
HP:0000821 Hypothyroidism 2
HP:0001638 Cardiomyopathy 2
HP:0001943 Hypoglycemia 2
HP:0002315 Headache 2
HP:0002902 Hyponatremia 2
HP:0004756 Ventricular tachycardia 2
HP:0000103 Polyuria 1
HP:0000822 Hypertension 1
HP:0000846 Adrenal insufficiency 1
HP:0000869 Secondary amenorrhea 1
HP:0000873 Diabetes insipidus 1
HP:0001250 Seizures 1
HP:0001664 Torsade de pointes 1
HP:0001698 Pericardial effusion 1
HP:0001876 Pancytopenia 1
HP:0002615 Hypotension 1
HP:0003201 Rhabdomyolysis 1
HP:0005521 Disseminated intravascular coagulation 1
HP:0030149 Cardiogenic shock 1
HP:0031273 Shock 1
HP:0031417 Rhinorrhea 1
HP:0031676 Monomorphic ventricular tachycardia 1
HP:0100646 Thyroiditis 1


Causative gene(s) retrieved from Orphanet

    Total: 0

Gene Symbol Gene Name Entrez Gene ID