Stevens-Johnson syndrome/toxic epidermal necrolysis spectrum

Toxic epidermal necrolysis (TEN) is an acute and severe skin disease with clinical and histological features characterized by the destruction and detachment of the skin epithelium and mucous membranes.



Input patient's signs and symptoms


Narrow down the case reports



Total: 33 (papers)

  


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)
PMID
(PMCID)
1
(39.8%)
15878074
Correlation of corneal complications with eyelid cicatricial pathologies in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis syndrome.
Di Pascuale MA, Espana EM, Liu DT, Kawakita T, Li W, Gao YY, Baradaran-Rafii A, Elizondo A, Raju VK, Tseng SC.
Ophthalmology. 2005;112(5):904-12.
Trichiasis Scarring
Adult Aged, 80 and over Child Child, Preschool Cicatrix Conjunctival Diseases Corneal Diseases Eyelid Diseases Females Homo sapiens Male Middle Aged Retrospective Studies Stevens-Johnson Syndrome Ulcer
2
(38.4%)
27078005
Cicatrizing Conjunctivitis in a Patient Diagnosed With Drug Reaction With Eosinophilia and Systemic Symptoms/Drug-Induced Hypersensitivity Syndrome but With Features of Stevens-Johnson Syndrome.
Bohm KJ, Ciralsky JB, Harp JL, Bajaj S, Sippel KC.
Cornea. 2016;35(6):888-91.
Conjunctivitis Scarring
Cicatrix Conjunctivitis Drug Hypersensitivity Syndrome Eosinophilia Glucocorticoids Homo sapiens Male Middle Aged Stevens-Johnson Syndrome
3
(30.8%)
26655481
Analysis of Ocular Manifestation and Genetic Association of Allopurinol-Induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in South Korea.
Lee HS, Ueta M, Kim MK, Seo KY, Sotozono C, Kinoshita S, Yoon KC.
Cornea. 2016;35(2):199-204.
Conjunctival hyperemia Symblepharon
HLA-B
Asians Conjunctival Diseases Drug Eruptions Females Genotype Genotyping Techniques Glucocorticoids Gout Suppressants HLA Antigens Homo sapiens Male Middle Aged Polymerase Chain Reaction Prospective Studies South Korea Stevens-Johnson Syndrome
4
(29.4%)
21148602
Systemic lupus erythematosus presenting as Stevens-Johnson syndrome and toxic epidermal necrolysis: a report of three cases.
Lee HY, Tey HL, Pang SM, Thirumoorthy T.
Lupus. 2011;20(6):647-52.
Conjunctivitis
Adult Child Conjunctivitis Females Glucocorticoids Homo sapiens Lupus Erythematosus, Systemic Middle Aged Stevens-Johnson Syndrome Stomatitis Ultraviolet Rays
5
(17.5%)
24933358
Otologic complications of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.
Hotaling JM, Hotaling AJ.
Int J Pediatr Otorhinolaryngol. 2014;78(8):1408-9.
Scarring
Child, Preschool Cicatrix Ear Deformities, Acquired Homo sapiens Male Stevens-Johnson Syndrome
5
(17.5%)
2196842
[Fatal Lyell's syndrome caused by griseofulvin].
Mion G, Le Gulluche Y, Carsin H, Verdon R, Paulet R.
Ann Fr Anesth Reanim. 1990;9(3):305-8.
Respiratory distress Rhabdomyolysis
Adult Females Homo sapiens Lymphopenia Pulmonary Edema Rhabdomyolysis Stevens-Johnson Syndrome
7
(4.0%)
31083216
Oseltamivir induced Stevens-Johnson syndrome/toxic epidermal necrolysis-case report.
Zuo W, Wen LP, Li J, Mei D, Fu Q, Zhang B.
Medicine (Baltimore). 2019;98(19):e15553.
Respiratory tract infection
Antiviral Agents Child Females HLA-A2 Antigen Homo sapiens Respiratory Tract Infections Stevens-Johnson Syndrome
7
(4.0%)
30186133
(6120418)
Atezolizumab-Induced Stevens-Johnson Syndrome in a Patient with Non-Small Cell Lung Carcinoma.
Chirasuthat P, Chayavichitsilp P.
Case Rep Dermatol. 2018;10(2):198-202.
Non-small cell lung carcinoma
CD274
7
(4.0%)
30175438
The use of etanercept for treatment of toxic epidermal necrolysis when toxic shock syndrome is in the differential.
So N, Leavitt E, Aleshin M, Worswick S.
Dermatol Ther. 2018;31(5):e12684.
Shock
TNF
Anti-Inflammatory Agents, Non-Steroidal Differential Diagnosis Females Homo sapiens Middle Aged Septic Shock Stevens-Johnson Syndrome
7
(4.0%)
30169429
Anti-programmed cell death-1 therapy-associated bullous disorders: a systematic review of the literature.
Zhao CY, Hwang SJE, Consuegra G, Chou S, Fernandez-Penas P.
Melanoma Res. 2018;28(6):491-501.
Eczema
PDCD1
Antibodies, Monoclonal, Humanized Cell Death Females Homo sapiens Male Monoclonal Antibodies Skin Neoplasms
        

Phenotype(s) retrieved from Orphanet

    Total: 0

HPO ID Term Frequency


Phenotype(s) retrieved from case reports

    Total: 13

HPO ID Term # of case reports
HP:0000964 Eczema 1
HP:0001875 Neutropenia 1
HP:0001880 Eosinophilia 1
HP:0001945 Fever 1
HP:0002480 Hepatic encephalopathy 1
HP:0010783 Erythema 1
HP:0011946 Bronchiolitis obliterans 1
HP:0012115 Hepatitis 1
HP:0012387 Bronchitis 1
HP:0012393 Allergy 1
HP:0031273 Shock 1
HP:0032156 Skin detachment 1
HP:0100699 Scarring 1


Causative gene(s) retrieved from Orphanet

    Total: 0

Gene Symbol Gene Name Entrez Gene ID