Neuroblastoma

Neuroblastoma is a malignant tumor of neural crest cells, the cells that give rise to the sympathetic nervous system, which is observed in children.

Pheochromocytoma

Pheochromocytomas (also known as chromaffin tumors) produce, store, and secrete catecholamines. Pheochromocytomas usually originate from the adrenal medulla but may also develop from chromaffin cells in or about sympathetic ganglia. A common symptom of pheochromocytoma is hypertension owing to release of catecholamines.


Total: 72

                      


(per page)
PMID (PMCID)
30829863
FEMALE Middle Aged
68Ga-DOTANOC PET/CT in an Atypical Extraskeletal Paravertebral Hemangioma Mimicking as Neurogenic Tumor in a Known Case of Breast Cancer.
Vadi SK, Mittal BR, Parihar AS, Kumar R, Singh H, Singh G.
Clin Nucl Med. 2019;44(5):e364-e366.
Ga-DOTANOC PET/CT is well documented in evaluation of well-differentiated neuroendocrine tumors and in other lesions with somatostatin receptor expression such as pheochromocytoma, paraganglioma, neuroblastoma, meningioma, and mesenchymal tumors causing oncogenic osteomalacia.
28409892
FEMALE
Failure of MIBG scan to detect metastases in SDHB-mutated pediatric metastatic pheochromocytoma.
Sait S, Pandit-Taskar N, Modak S.
Pediatr Blood Cancer. 2017;64(11):.
We describe a pediatric patient initially considered to have localized neuroblastoma based on anatomical imaging and 123 I-MIBG scan, but subsequent investigations revealed germline succinate dehydrogenase complex iron sulfur subunit B (SDHB) mutation-associated pheochromocytoma with multiple FDG-avid skeletal metastases.
28409892
FEMALE
Failure of MIBG scan to detect metastases in SDHB-mutated pediatric metastatic pheochromocytoma.
Sait S, Pandit-Taskar N, Modak S.
Pediatr Blood Cancer. 2017;64(11):.
123 I-meta-iodo benzyl guanidine (MIBG) scans are considered the gold standard imaging in neuroblastoma; however, flouro deoxy glucose positron emission tomography (FDG-PET) scans have increased sensitivity in adults with pheochromocytoma/paraganglioma.
27051319
(4803264)
OTHER
Childhood neuroblastoma masquerading as pheochromocytoma: case report.
Moon SB.
Int Med Case Rep J. 2016;9:65-7.
Childhood neuroblastoma masquerading as pheochromocytoma: case report.
26207436
FEMALE
Unusual Differentiation to Pheochromocytoma-Like Cells in an Adrenal Neuroblastoma After Chemotherapy: A Case Report and Literature Review.
Tatekawa Y.
Fetal Pediatr Pathol. 2015;34(5):322-7.
Unusual Differentiation to Pheochromocytoma-Like Cells in an Adrenal Neuroblastoma After Chemotherapy: A Case Report and Literature Review.
26207436
FEMALE
Unusual Differentiation to Pheochromocytoma-Like Cells in an Adrenal Neuroblastoma After Chemotherapy: A Case Report and Literature Review.
Tatekawa Y.
Fetal Pediatr Pathol. 2015;34(5):322-7.
Pathological findings of the resected tumor revealed that most of the neuroblastoma tissues changed to pheochromocytoma-like cells.
23455526
FEMALE Middle Aged
MIBG superscan of metastatic paraganglioma occurring with neurofibromatosis type 1.
Harrison CE, Barron BJ.
Clin Nucl Med. 2013;38(6):459-62.
A similar phenomenon has been described with metaiodobenzylguanidine (MIBG) in metastatic pheochromocytoma and neuroblastoma.
20147848
FEMALE Infant
Giant, dopamine secreting thoracoabdominal neuroblastoma in a 2-year-old: rapid preoperative blockade with labetalol.
Pappas L, Shamberger RC, Seefelder C.
J Pediatr Hematol Oncol. 2010;32(2):163-6.
Neuroblastomas secreting large amounts of catecholamines may require preoperative antihypertensive treatment to avoid intraoperative hypertensive crises as do pheochromocytomas.
19864235
MIXED_SAMPLE Child
Composite pheochromocytoma: a clinicopathologic and molecular comparison with ordinary pheochromocytoma and neuroblastoma.
Comstock JM, Willmore-Payne C, Holden JA, Coffin CM.
Am J Clin Pathol. 2009;132(1):69-73.
Composite pheochromocytoma: a clinicopathologic and molecular comparison with ordinary pheochromocytoma and neuroblastoma.
19864235
MIXED_SAMPLE Child
Composite pheochromocytoma: a clinicopathologic and molecular comparison with ordinary pheochromocytoma and neuroblastoma.
Comstock JM, Willmore-Payne C, Holden JA, Coffin CM.
Am J Clin Pathol. 2009;132(1):69-73.
This study investigates the clinical characteristics and N-myc amplification status of 4 cases of composite pheochromocytoma and compares them with selected cases of ordinary pheochromocytoma and neuroblastoma.
19864235
MIXED_SAMPLE Child
Composite pheochromocytoma: a clinicopathologic and molecular comparison with ordinary pheochromocytoma and neuroblastoma.
Comstock JM, Willmore-Payne C, Holden JA, Coffin CM.
Am J Clin Pathol. 2009;132(1):69-73.
This study investigates the clinical characteristics and N-myc amplification status of 4 cases of composite pheochromocytoma and compares them with selected cases of ordinary pheochromocytoma and neuroblastoma.
18726616
MIXED_SAMPLE Adult
A germline mutation of the KIF1B beta gene on 1p36 in a family with neural and nonneural tumors.
Yeh IT, Lenci RE, Qin Y, Buddavarapu K, Ligon AH, Leteurtre E, Do Cao C, Cardot-Bauters C, Pigny P, Dahia PL.
Hum Genet. 2008;124(3):279-85.
KIF1B beta mutations were detected in pheochromocytomas and neuroblastomas, two sympathetic lineage tumors, suggesting a role for this gene in cancer.
18705773
FEMALE Adult
Malignant pheochromocytoma in a young adult forming the structure simulating Homer Wright rosette: differentiation from neuroblastoma on repeating fluorescence in situ hybridization.
Mori H, Nagata M, Nishijima N, Nagura K, Igarashi H, Hamazaki M, Ozono S, Sugimura H.
Pathol Int. 2008;58(8):518-23.
FISH demonstrated loss of heterozygosity at 11p, and gains at 16p, 19p, and 19q, a profile that favored a diagnosis of malignant pheochromocytoma over neuroblastoma.
18705773
FEMALE Adult
Malignant pheochromocytoma in a young adult forming the structure simulating Homer Wright rosette: differentiation from neuroblastoma on repeating fluorescence in situ hybridization.
Mori H, Nagata M, Nishijima N, Nagura K, Igarashi H, Hamazaki M, Ozono S, Sugimura H.
Pathol Int. 2008;58(8):518-23.
Malignant pheochromocytoma in a young adult forming the structure simulating Homer Wright rosette: differentiation from neuroblastoma on repeating fluorescence in situ hybridization.
18705773
FEMALE Adult
Malignant pheochromocytoma in a young adult forming the structure simulating Homer Wright rosette: differentiation from neuroblastoma on repeating fluorescence in situ hybridization.
Mori H, Nagata M, Nishijima N, Nagura K, Igarashi H, Hamazaki M, Ozono S, Sugimura H.
Pathol Int. 2008;58(8):518-23.
Because these results did not rule out a diagnosis of neuroblastoma, the tumor was further characterized on FISH with multiple BAC probes for loci known to be altered in neuroblastoma or pheochromocytoma, according to information in the literature that was for the most part obtained using comparative genomic hybridization.
18705773
FEMALE Adult
Malignant pheochromocytoma in a young adult forming the structure simulating Homer Wright rosette: differentiation from neuroblastoma on repeating fluorescence in situ hybridization.
Mori H, Nagata M, Nishijima N, Nagura K, Igarashi H, Hamazaki M, Ozono S, Sugimura H.
Pathol Int. 2008;58(8):518-23.
Because these results did not rule out a diagnosis of neuroblastoma, the tumor was further characterized on FISH with multiple BAC probes for loci known to be altered in neuroblastoma or pheochromocytoma, according to information in the literature that was for the most part obtained using comparative genomic hybridization.
18057081
MIXED_SAMPLE Child
Molecular characterisation of a common SDHB deletion in paraganglioma patients.
Cascon A, Landa I, Lopez-Jimenez E, Diez-Hernandez A, Buchta M, Montero-Conde C, Leskela S, Leandro-Garcia LJ, Leton R, Rodriguez-Antona C, Eng C, Neumann HP, Robledo M.
J Med Genet. 2008;45(4):233-8.
Moreover, we found for the first time a patient with neuroblastoma and a germline SDHB deletion, but it seems that this paediatric neoplasia in a pheochromocytoma family is not a key component of this disease.
17537029
MIXED_SAMPLE Infant
Nine cases of childhood adrenal tumour presenting with hypertension and a review of the literature.
Wang X, Liang L, Jiang Y.
Acta Paediatr. 2007;96(6):930-4.
Pheochromocytoma (n = 2), adrenocortical adenoma (n = 3), adrenocortical carcinoma (n = 1), neuroblastoma (n = 2) and ganglioneuromas (n = 1) were found.
16481267
MALE
Composite pheochromocytoma associated with adrenal neuroblastoma in an infant: a case report.
Tatekawa Y, Muraji T, Nishijima E, Yoshida M, Tsugawa C.
J Pediatr Surg. 2006;41(2):443-5.
Immunoreactivity for vimentin was positive in pheochromocytoma, which was negative in neuroblastoma.
16481267
MALE
Composite pheochromocytoma associated with adrenal neuroblastoma in an infant: a case report.
Tatekawa Y, Muraji T, Nishijima E, Yoshida M, Tsugawa C.
J Pediatr Surg. 2006;41(2):443-5.
Composite pheochromocytoma associated with adrenal neuroblastoma in an infant: a case report.