Glucagonoma

Glucagonoma is a rare, functioning type of pancreatic neuroendocrine tumor (PNET; see this term) that hypersecretes glucagon, leading to a syndrome comprised of necrolytic migratory erythema, diabetes mellitus, anemia, weight loss, mucosal abnormalities, thromboembolism, gastrointestinal and neuropsychiatric symptoms.

Diabetes mellitus

A group of abnormalities characterized by hyperglycemia and glucose intolerance.


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PMID (PMCID)
26622635
 OTHER
Glucagonoma syndrome: A case report.
Wei J, Lin S, Wang C, Wu J, Qian Z, Dai C, Jiang K, Miao YI.
Oncol Lett. 2015;10(2):1113-1116.
Necrolytic migratory erythema (NME), diabetes mellitus and glucagon-secreting tumors form the hallmarks of glucagonoma syndrome, and represent the major clinical manifestations of glucagonoma.
26622635
 OTHER
Glucagonoma syndrome: A case report.
Wei J, Lin S, Wang C, Wu J, Qian Z, Dai C, Jiang K, Miao YI.
Oncol Lett. 2015;10(2):1113-1116.
Necrolytic migratory erythema (NME), diabetes mellitus and glucagon-secreting tumors form the hallmarks of glucagonoma syndrome, and represent the major clinical manifestations of glucagonoma.
23890147
 FEMALE Middle Aged
Necrolytic migratory erythema and glucagonoma rising from pancreatic head.
Tseng HC, Liu CT, Ho JC, Lin SH.
Pancreatology. 2013;13(4):455-7.
Glucagonoma syndrome encompasses necrolytic migratory erythema (NME), hyperglucagonemia, diabetes mellitus, anemia, weight loss, glossitis, angular cheilitis, steatorrhea, diarrhea, venous thrombosis, and neuropsychiatric disturbance.
23719610
 MALE Middle Aged
Pancreatic glucagonoma with pancreatic calcification.
Gupta RA, Udwadia FE, Agrawal P, Doctor N.
Pancreatology. 2013;13(3):327-9.
Glucagonoma is an uncommon type of pancreatic neuroendocrine tumor [NET] which is characterized by diabetes mellitus, necrolytic migratory erythema, depression and deep vein thrombosis.
23644134
 MALE Middle Aged
[Diagnosis and treatment of glucagonoma: report of one case].
Cheng H, Chen M, Yang G.
Nan Fang Yi Ke Da Xue Xue Bao. 2013;33(4):618-insidebackcover.
We report a case of glucagonoma in a 55-year-old male patient with such clinical findings of necrolytic migratory erythema, diabetes mellitus, body weight loss, and anemia.
19014744
 MALE Middle Aged
[Glucagonoma syndrome without diabetes mellitus].
Mikkelsen CS, Mikkelsen DB, Vestergaard V, Clemmensen O, Nielsen HO, Bygum A.
Ugeskr Laeger. 2008;170(47):3876.
[Glucagonoma syndrome without diabetes mellitus].
17926496
 FEMALE Middle Aged
[A case of pancreatic glucagonoma].
Simonenko VB, Dulin PA, Beliaev LB, Makanin MA, Dem'ianenko AV, Zykova AA, Zhuravleva SI, Kolesnikova VN.
Klin Med (Mosk). 2007;85(8):67-70.
Glucagonoma syndrome is a disease that has an original clinical picture that includes necrolytic migrating erythema with secondary bullous dermatitis, glucose tolerance disorder or diabetes mellitus, weight loss, anemia, hypoaminoacidemia, venous thrombosis, and alimentary and mental disturbances.
16362349
 FEMALE Middle Aged
[The question of surgical therapy for necrolytic migratory erythema, a cutaneous disease].
Siegel R, Linse R, Rau B.
Chirurg. 2006;77(6):535-8.
The glucagonoma syndrome is characterised by pancreatic neuroendocrine neoplasm, NME, and diabetes mellitus.
15959605
 MALE Middle Aged
Rare presentation of endocrine pancreatic tumor: a case of diffuse glucagonoma without metastasis and necrolytic migratory erythema.
Chen HW, Chen HW, Su DH, Shun CT, Liu KL.
J Formos Med Assoc. 2005;104(5):363-6.
We report a case of diffuse glucagonoma necrolytic migratory erythema (NME) in a 45-year-old man with mild diabetes mellitus, mild anemia, and weight loss over 1.5 years.
15313692
 MALE Middle Aged
Clinical experience in diagnosis and treatment of glucagonoma syndrome.
Zhang M, Xu X, Shen Y, Hu ZH, Wu LM, Zheng SS.
Hepatobiliary Pancreat Dis Int. 2004;3(3):473-5.
The clinical data of a case of pancreatic head tumor with typical glucagonoma syndrome of necrolytic migratory erythema (NME), diabetes mellitus (DM), anemia, and glossitis were retrospectively analyzed.
12918465
 MALE
Malignant glucagonoma of the pancreas diagnoses through anemia and diabetes mellitus.
Koike N, Hatori T, Imaizumi T, Harada N, Fukuda A, Takasaki K, Iwamoto Y.
J Hepatobiliary Pancreat Surg. 2003;10(1):101-5.
Malignant glucagonoma of the pancreas diagnoses through anemia and diabetes mellitus.
12918465
 MALE
Malignant glucagonoma of the pancreas diagnoses through anemia and diabetes mellitus.
Koike N, Hatori T, Imaizumi T, Harada N, Fukuda A, Takasaki K, Iwamoto Y.
J Hepatobiliary Pancreat Surg. 2003;10(1):101-5.
Therefore, we recommend checking patients who have diabetes mellitus and anemia in order to diagnose and treat glucagonoma in its early stage.
12918465
 MALE
Malignant glucagonoma of the pancreas diagnoses through anemia and diabetes mellitus.
Koike N, Hatori T, Imaizumi T, Harada N, Fukuda A, Takasaki K, Iwamoto Y.
J Hepatobiliary Pancreat Surg. 2003;10(1):101-5.
We report the case of a 68-year-old Japanese man who underwent curative resection for malignant glucagonoma of the pancreas diagnosed through anemia and diabetes mellitus.
12918465
 MALE
Malignant glucagonoma of the pancreas diagnoses through anemia and diabetes mellitus.
Koike N, Hatori T, Imaizumi T, Harada N, Fukuda A, Takasaki K, Iwamoto Y.
J Hepatobiliary Pancreat Surg. 2003;10(1):101-5.
Glucagonoma of the pancreas is a rare tumor with distinct clinical manifestations, such as necrolytic migratory erythema,weight loss, anemia, diabetes mellitus, and hypoamino-acidemia.
10985071
 MALE
[Glucagon-secreting malignant neuroendocrine tumor of the pancreas].
Wickenhauser C, Aichelmann E, Neuhaus H, Holscher AH, Dienes HP.
Med Klin (Munich). 2000;95(8):466-9.
An unclear migratory erythema combined with diabetes mellitus and stomatitis/cheilosis should lead to the differential diagnosis of glucagonoma.
10502856
 MALE Middle Aged
Glucagonoma syndrome: a case report.
Shyr YM, Su CH, Lee CH, Wu CW, Lui WY.
Zhonghua Yi Xue Za Zhi (Taipei). 1999;62(9):639-43.
We present a case of pancreatic tail tumor with the typical glucagonoma syndrome of necrolytic migratory erythema (NME), diabetes mellitus (DM), anemia, weight loss and glossitis.
7648942
 MALE Middle Aged
[Report of a case of glucagonoma misdiagnosed as "eczema" and "hepatic angioma" for three years and review of literature].
Dai W, Shi Y, Cai L.
Zhonghua Nei Ke Za Zhi. 1995;34(3):190-2.
Glucagonoma is a rare pancreatic tumor, necrolytic migratory erythema is its distinctive feature and it is often associated with diabetes mellitus, weight loss, anemia, hypoaminoacidemia, glossitis and stomatitis.
7528001
 FEMALE Middle Aged
Glucagonoma syndrome with increased lactate dehydrogenase isoenzymes: octreotide treatment.
Siller GM, Strutton GM, Moore GA, Kanowski DM, Nedwich JA.
Australas J Dermatol. 1994;35(1):11-4.
Glucagonoma Syndrome is a rare syndrome comprising hyperglucagonemia, diabetes mellitus, necrolytic migratory erythema and hypoaminoacidemia in the setting of a glucagon producing, alpha cell tumour of the pancreas.
1655838
 MALE Middle Aged
Necrolytic migratory erythema without glucagonoma versus canine superficial necrolytic dermatitis: is hepatic impairment a clue to pathogenesis?
Kasper CS, McMurry K.
J Am Acad Dermatol. 1991;25(3):534-41.
In addition to a necrolytic dermatitis, both our patient and most dogs with superficial necrolytic dermatitis have diabetes mellitus and hepatic failure in the absence of glucagonoma.
2276959
 MIXED_SAMPLE
Glucagon-producing pancreatic endocrine tumors in two dogs with superficial necrolytic dermatitis.
Gross TL, O'Brien TD, Davies AP, Long RE.
J Am Vet Med Assoc. 1990;197(12):1619-22.
Clinically and histologically, skin lesions closely resembled necrolytic migratory erythema of people, a skin disease that usually is associated with a glucagon-secreting pancreatic endocrine tumor and diabetes mellitus (glucagonoma syndrome): The morphologically descriptive term, superficial necrolytic dermatitis, was preferred over the previously proposed names hepatocutaneous syndrome and diabetic dermatopathy, which each connote only a single feature of the disease.