Glucagonoma

Glucagonoma is a rare, functioning type of pancreatic neuroendocrine tumor (PNET; see this term) that hypersecretes glucagon, leading to a syndrome comprised of necrolytic migratory erythema, diabetes mellitus, anemia, weight loss, mucosal abnormalities, thromboembolism, gastrointestinal and neuropsychiatric symptoms.

Diabetes mellitus

A group of abnormalities characterized by hyperglycemia and glucose intolerance.


Total: 25

                       


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PMID (PMCID)
3004244
 FEMALE Middle Aged
Functioning oncocytic islet-cell carcinoma. Report of a case with electron-microscopic and immunohistochemical confirmation.
Radi MJ, Fenoglio-Preiser CM, Chiffelle T.
Am J Surg Pathol. 1985;9(7):517-24.
The patient exhibited some of the clinical features associated with glucagonoma syndrome, including diabetes mellitus and chronic diarrhea.
2994032
 MALE Middle Aged
Glucagonoma without cutaneous manifestations.
Parr JH, Ramsay ID, Keeling PW, Thompson RP, Mallinson CN.
Postgrad Med J. 1985;61(718):737-8.
A 63 year old man presented with features of the glucagonoma syndrome, that is thromboembolic disease, weight loss, raised sedimentation rate, diabetes mellitus, hypoproteinaemia and reduced plasma amino acid levels, but without necrolytic migratory erythema.
3914790
 MALE
[Unusual abdominal apudomas. II. Immunohistochemical detection of glucagon in a primary apudoma of the liver].
Gottschalk J, Schulz HJ, Frommel M.
Zentralbl Allg Pathol. 1985;130(6):463-6.
Clinically the 66 year old patient had presented with an abortive form of the glucagonoma syndrome with diabetes mellitus, anemia and profound weight loss.
6258130
 FEMALE Middle Aged
[Clinical, biological, histological, ultrastructural and therapeutic studies in one case (author's transl)].
Lubetzki J, Grupper C, Malbec D, Warnet A, Guillausseau PJ, Luyckx A, Hautefeuille P, Galian A, Scotto J, Rault P, Eskenazi A, Mathieu M.
Nouv Presse Med. 1980;9(22):1565-9.
The diagnosis of glucagonoma was made in a 51 year-old woman who suffered from a polymorphous dermatitis and an insulin-dependent diabetes mellitus.
228832
 MALE Adult
Neurologic involvement in glucagonoma syndrome: response to combination chemotherapy with 5-fluorouracil and streptozotocin.
Khandekar JD, Oyer D, Miller HJ, Vick NA.
Cancer. 1979;44(6):2014-6.
A 34-year-old man presented with classic glucagonoma syndrome manifested by weight loss, dermatitis, stomatitis, anemia, and mild diabetes mellitus.