Legg-Calvé-Perthes disease

A rare disorder characterized by uni- or bilateral avascular necrosis (AVN) of the femoral head in children.



Input patient's signs and symptoms


Narrow down the case reports



Total: 84 (papers)

  


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)
PMID
(PMCID)
20
(30.2%)
12973039
Perthes' disease associated with osteogenesis imperfecta.
Petra M, Benson MK.
J Pediatr Orthop B. 2003;12(5):315-8.
Osteopenia Coxa vara
Child Comorbidity Hip Joint Homo sapiens Legg-Calve-Perthes Disease Male Osteogenesis Imperfecta Range of Motion, Articular
20
(30.2%)
11675885
Hip arthroscopy in the adolescent and pediatric athlete.
Berend KR, Vail TP.
Clin Sports Med. 2001;20(4):763-78.
Coxa vara
Arthralgia Arthroscopy Athletic Injuries Child Females Hip Injuries Hip Joint Homo sapiens Legg-Calve-Perthes Disease Male
23
(29.2%)
26511699
Mosaicplasty for the treatment of osteochondritis dissecans following Legg-Calve-Perthes disease: a case report and literature review.
Gagala J, Tarczynska M, Gaweda K.
Acta Orthop Traumatol Turc. 2015;49(6):694-7.
Hip dislocation
Adult Bone Transplantation Hip Joint Homo sapiens Legg-Calve-Perthes Disease Male Osteochondritis Dissecans Transplantation, Autologous X-Ray Computed Tomography
23
(29.2%)
22696637
Delayed diagnosis of traumatic hip dislocation mimicking Perthes disease in a child.
Singhal R, Perry D, Cohen D, Bruce C.
BMJ Case Rep. 2011;2011:.
Hip dislocation
Child, Preschool Delayed Diagnosis Hip Dislocation Homo sapiens Legg-Calve-Perthes Disease Male Osteotomy
23
(29.2%)
21442341
Two novel COL2A1 mutations associated with a Legg-Calve-Perthes disease-like presentation.
Kannu P, Irving M, Aftimos S, Savarirayan R.
Clin Orthop Relat Res. 2011;469(6):1785-90.
Hip dysplasia
COL2A1
Child, Preschool DNA Females Follow-Up Studies Homo sapiens Infant, Newborn Legg-Calve-Perthes Disease Male Mutation Polymerase Chain Reaction Prospective Studies
23
(29.2%)
14530696
Triple pelvic osteotomy in Legg-Calve-Perthes disease using a single anterolateral incision.
O'Connor PA, Mulhall KJ, Kearns SR, Sheehan E, McCormack D, Mullhall KJ.
J Pediatr Orthop B. 2003;12(6):387-9.
Acetabular dysplasia
Child Homo sapiens Legg-Calve-Perthes Disease Male Osteotomy Pelvic Bones
23
(29.2%)
3780093
Etiology of osteoarthritis of the hip.
Harris WH.
Clin Orthop Relat Res. 1986;(213):20-33.
Rheumatoid arthritis Acetabular dysplasia
Adult Bone Diseases, Developmental Epiphyses, Slipped Females Follow-Up Studies Hip Joint Homo sapiens Legg-Calve-Perthes Disease Male Middle Aged
23
(29.2%)
2394820
Avascular necrosis of the capital femoral epiphysis in metachondromatosis.
Keret D, Bassett GS.
J Pediatr Orthop. 1990;10(5):658-61.
Coxa magna
Child, Preschool Chondroma Femur Head Necrosis Hereditary Multiple Exostoses Homo sapiens Male
23
(29.2%)
547953
Resurfacing arthroplasty of the hip. Biomechanical, morphological, and clinical aspects based on the results of a preliminary clinical study.
Goldie IF, Bunketorp O, Gunterberg B, Hansson T, Myrhage R.
Arch Orthop Trauma Surg. 1979;95(3):149-57.
Hip dysplasia
Adult Biomechanical Phenomena Females Homo sapiens Male Middle Aged
30
(26.3%)
20497760
A case of frequently relapsing nephrotic syndrome combined with Perthes disease.
Mori K.
Clin Nephrol. 2010;73(6):473-7.
Nephrotic syndrome Facial edema
Child, Preschool Glucocorticoids Homo sapiens Legg-Calve-Perthes Disease Magnetic Resonance Imaging Male Nephrotic Syndrome
        

Phenotype(s) retrieved from Orphanet

    Total: 8

HPO ID Term Frequency
HP:0000164 Abnormality of the dentition Very frequent (99-80%)
HP:0001373 Joint dislocation Very frequent (99-80%)
HP:0002750 Delayed skeletal maturation Very frequent (99-80%)
HP:0002829 Arthralgia Very frequent (99-80%)
HP:0003202 Skeletal muscle atrophy Very frequent (99-80%)
HP:0004322 Short stature Very frequent (99-80%)
HP:0010885 Avascular necrosis Very frequent (99-80%)
HP:0100773 Cartilage destruction Very frequent (99-80%)


Phenotype(s) retrieved from case reports

    Total: 43

HPO ID Term # of case reports
HP:0003095 Septic arthritis 6
HP:0100769 Synovitis 5
HP:0002656 Epiphyseal dysplasia 4
HP:0002754 Osteomyelitis 4
HP:0002655 Spondyloepiphyseal dysplasia 3
HP:0030838 Hip pain 3
HP:0000821 Hypothyroidism 2
HP:0001369 Arthritis 2
HP:0001909 Leukemia 2
HP:0002758 Osteoarthritis 2
HP:0002812 Coxa vara 2
HP:0008807 Acetabular dysplasia 2
HP:0000100 Nephrotic syndrome 1
HP:0000252 Microcephaly 1
HP:0000324 Facial asymmetry 1
HP:0000639 Nystagmus 1
HP:0000819 Diabetes mellitus 1
HP:0000979 Purpura 1
HP:0001159 Syndactyly 1
HP:0001250 Seizures 1
HP:0001385 Hip dysplasia 1
HP:0001513 Obesity 1
HP:0002301 Hemiplegia 1
HP:0002650 Scoliosis 1
HP:0002721 Immunodeficiency 1
HP:0002808 Kyphosis 1
HP:0002827 Hip dislocation 1
HP:0002857 Genu valgum 1
HP:0002944 Thoracolumbar scoliosis 1
HP:0003302 Spondylolisthesis 1
HP:0003304 Spondylolysis 1
HP:0008843 Hip osteoarthritis 1
HP:0010740 Osteopathia striata 1
HP:0011002 Osteopetrosis 1
HP:0012062 Bone cyst 1
HP:0030431 Osteochondroma 1
HP:0030772 Proximal femoral focal deficiency 1
HP:0030836 Wrist pain 1
HP:0030839 Knee pain 1
HP:0100259 Postaxial polydactyly 1
HP:0100646 Thyroiditis 1
HP:0100777 Exostoses 1
HP:0100806 Sepsis 1


Causative gene(s) retrieved from Orphanet

    Total: 1

Gene Symbol Gene Name Entrez Gene ID
COL2A1 collagen type II alpha 1 chain 1280