Plasmacytoma

Plasmacytoma is a localized mass of neoplastic monoclonal plasma cells that represents approximately 5% of all plasma cell neoplasms. There are two separate entities: primary plasmacytoma of the bone and extramedullary plasmacytoma of the soft tissues. Of the extramedullary plasmacytomas, 80% occur in the head and neck, usually in the upper respiratory tract. The median age at diagnosis is 50 years and the male to female ratio is 3:1. Long-term survival is possible following local radiotherapy, particularly for soft tissue presentations.



Input patient's signs and symptoms


Narrow down the case reports



Total: 1002 (papers)

  


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)
PMID
(PMCID)
1
(54.2%)
30254770
(6142722)
Biliary Obstruction due to a Pancreatic Plasmacytoma.
Cho MH, Mandaliya R, Tran J, Lee W, Patel M.
Case Rep Gastrointest Med. 2018;2018:9017617.
Jaundice Anemia Hypercalcemia
1
(54.2%)
8608506
Extensive extramedullary disease in myeloma. An uncommon variant with features of poor prognosis and dedifferentiation.
Sanal SM, Yaylaci M, Mangold KA, Pantazis CG.
Cancer. 1996;77(7):1298-302.
Jaundice Anemia Hypercalcemia
HRAS NRAS
Homo sapiens Immunohistochemistry Male Multiple Myeloma Plasmacytoma
3
(49.7%)
2516813
[Primary plasmacytoma of the thyroid--report of an autopsy case and review of the literature in Japan].
Hosojima H, Morimoto S, Takashima S, Kinami Y, Konishi F.
Nihon Naibunpi Gakkai Zasshi. 1989;65(12):1367-75.
Ascites Anemia Hypoalbuminemia
Females Homo sapiens Immunoglobulin kappa-Chains Plasma Cells Plasmacytoma Thyroid Neoplasm Thyroidectomy
4
(48.0%)
19287115
Pancreatic plasmacytoma presenting as variceal hemorrhage: life threatening complication of a rare entity.
Atiq M, Ali SA, Dang S, Krishna SG, Anaisse E, Olden KW, Aduli F.
JOP. 2009;10(2):187-8.
Jaundice Anemia
Differential Diagnosis Esophageal and Gastric Varices Females Gastrointestinal Hemorrhage Homo sapiens Middle Aged Pancreatic Neoplasm Plasmacytoma
4
(48.0%)
6521954
[Clinical and diagnostic considerations on a case of pancreatic plasmacytoma].
Borgia G, Ciampi R, Nappa S, Vallone G, Iovinella V, Crowell J.
Minerva Med. 1984;75(47-48):2839-42.
Jaundice Anemia
Females Homo sapiens Middle Aged Multiple Myeloma Pancreas Pancreatic Neoplasm Plasmacytoma
6
(47.4%)
19830241
(2737756)
Extramedullary plasmacytoma of the pancreas as an uncommon cause of obstructive jaundice: a case report.
Leake PA, Coard KC, Plummer JM.
J Med Case Rep. 2009;3:8785.
Jaundice Rouleaux formation
7
(45.3%)
22783007
Polyneuropathy: a poetic diagnosis.
Pattani R, Rozenberg D, Mozessohn L, Hicks L.
BMJ Case Rep. 2012;2012:.
Splenomegaly Thrombocytosis Fever
Biopsy Differential Diagnosis Electromyography Females Homo sapiens Middle Aged POEMS Syndrome X-Ray Computed Tomography
8
(44.2%)
16860182
Renal involvement in multicentric Castleman disease with glomeruloid hemangioma of skin and plasmacytoma.
Uthup S, Balachandran K, Ammal VA, Abdul Salam R, George J, Nair GM, Leela M.
Am J Kidney Dis. 2006;48(2):e17-24.
Proteinuria Hepatomegaly Plasmacytosis
Biopsy Glomerulonephritis, Membranoproliferative Hemangioma Homo sapiens Immunosuppressive Agents Male Middle Aged Plasmacytoma Skin Neoplasms Steroids
9
(43.8%)
19715046
Multiple myeloma presenting as cervical lymphadenopathy in a 16-year-old boy.
Brady-West DC, Buchner-Daley LM, McGrowder DA, Taylor-Houston J, West KA.
J Natl Med Assoc. 2009;101(8):810-2.
Anemia Hypercalcemia Cervical lymphadenopathy
B2M MYOM2
Antineoplastic Combined Chemotherapy Protocols Combined Modality Therapy Head and Neck Neoplasms Homo sapiens Lymphatic Diseases Male Multiple Myeloma
10
(42.9%)
2089175
Evans' syndrome associated with gastric plasmacytoma: case report and a review of the literature.
Yonekura S, Nagao T, Arimori S, Miyaji M, Ogoshi K, Tsutsumi Y.
Jpn J Med. 1990;29(5):512-5.
Purpura Hemolytic anemia
Adult Antineoplastic Combined Chemotherapy Protocols Combined Modality Therapy Females Gastrectomy Homo sapiens Plasmacytoma Remission Induction Splenectomy Stomach Neoplasms Syndrome
        

Phenotype(s) retrieved from Orphanet

    Total: 0

HPO ID Term Frequency


Phenotype(s) retrieved from case reports

    Total: 179

HPO ID Term # of case reports
HP:0002664 Neoplasm 85
HP:0002835 Aspiration 38
HP:0030731 Carcinoma 32
HP:0001271 Polyneuropathy 18
HP:0005523 Lymphoproliferative disorder 15
HP:0032252 Granuloma 13
HP:0000952 Jaundice 12
HP:0002202 Pleural effusion 10
HP:0002861 Melanoma 9
HP:0031047 Paraproteinemia 9
HP:0001541 Ascites 8
HP:0002860 Squamous cell carcinoma 8
HP:0030150 Plasmacytosis 7
HP:0100242 Sarcoma 7
HP:0001909 Leukemia 6
HP:0002716 Lymphadenopathy 6
HP:0003072 Hypercalcemia 6
HP:0002094 Dyspnea 5
HP:0002176 Spinal cord compression 5
HP:0002576 Intussusception 5
HP:0009830 Peripheral neuropathy 5
HP:0025615 Abscess 5
HP:0100646 Thyroiditis 5
HP:0000520 Proptosis 4
HP:0000969 Edema 4
HP:0001028 Hemangioma 4
HP:0002090 Pneumonia 4
HP:0003002 Breast carcinoma 4
HP:0005202 Helicobacter pylori infection 4
HP:0012115 Hepatitis 4
HP:0012315 Histiocytoma 4
HP:0001085 Papilledema 3
HP:0001945 Fever 3
HP:0002015 Dysphagia 3
HP:0002027 Abdominal pain 3
HP:0002721 Immunodeficiency 3
HP:0010614 Fibroma 3
HP:0012735 Cough 3
HP:0100658 Cellulitis 3
HP:0100825 Cheilitis 3
HP:0000246 Sinusitis 2
HP:0000501 Glaucoma 2
HP:0000508 Ptosis 2
HP:0000620 Dacryocystitis 2
HP:0000651 Diplopia 2
HP:0000793 Membranoproliferative glomerulonephritis 2
HP:0000853 Goiter 2
HP:0000872 Hashimoto thyroiditis 2
HP:0001082 Cholecystitis 2
HP:0001138 Optic neuropathy 2
HP:0001289 Confusion 2
HP:0001433 Hepatosplenomegaly 2
HP:0001978 Extramedullary hematopoiesis 2
HP:0002196 Myelopathy 2
HP:0002385 Paraparesis 2
HP:0002756 Pathologic fracture 2
HP:0002862 Bladder carcinoma 2
HP:0002878 Respiratory failure 2
HP:0003003 Colon cancer 2
HP:0003418 Back pain 2
HP:0008462 Cervical instability 2
HP:0010550 Paraplegia 2
HP:0012125 Prostate cancer 2
HP:0012366 Basilar invagination 2
HP:0030156 Bence Jones Proteinuria 2
HP:0031281 Sialadenitis 2
HP:0031357 Glomeruloid hemangioma 2
HP:0031500 Abdominal mass 2
HP:0032404 Testicular mass 2
HP:0100727 Histiocytosis 2
HP:0100796 Orchitis 2
HP:0200036 Skin nodule 2
HP:0200123 Chronic hepatitis 2
HP:0000083 Renal insufficiency 1
HP:0000093 Proteinuria 1
HP:0000100 Nephrotic syndrome 1
HP:0000112 Nephropathy 1
HP:0000126 Hydronephrosis 1
HP:0000135 Hypogonadism 1
HP:0000212 Gingival overgrowth 1
HP:0000265 Mastoiditis 1
HP:0000572 Visual loss 1
HP:0000648 Optic atrophy 1
HP:0000771 Gynecomastia 1
HP:0000790 Hematuria 1
HP:0000819 Diabetes mellitus 1
HP:0000821 Hypothyroidism 1
HP:0000843 Hyperparathyroidism 1
HP:0000921 Missing ribs 1
HP:0000938 Osteopenia 1
HP:0000961 Cyanosis 1
HP:0000979 Purpura 1
HP:0001007 Hirsutism 1
HP:0001056 Milia 1
HP:0001067 Neurofibromas 1
HP:0001101 Iritis 1
HP:0001250 Seizures 1
HP:0001287 Meningitis 1
HP:0001332 Dystonia 1
HP:0001336 Myoclonus 1
HP:0001369 Arthritis 1
HP:0001370 Rheumatoid arthritis 1
HP:0001482 Subcutaneous nodule 1
HP:0001618 Dysphonia 1
HP:0001635 Congestive heart failure 1
HP:0001649 Tachycardia 1
HP:0001698 Pericardial effusion 1
HP:0001701 Pericarditis 1
HP:0001733 Pancreatitis 1
HP:0001735 Acute pancreatitis 1
HP:0001742 Nasal obstruction 1
HP:0001873 Thrombocytopenia 1
HP:0001875 Neutropenia 1
HP:0001880 Eosinophilia 1
HP:0001894 Thrombocytosis 1
HP:0001903 Anemia 1
HP:0001919 Acute kidney injury 1
HP:0001972 Macrocytic anemia 1
HP:0001974 Leukocytosis 1
HP:0002014 Diarrhea 1
HP:0002098 Respiratory distress 1
HP:0002099 Asthma 1
HP:0002102 Pleuritis 1
HP:0002105 Hemoptysis 1
HP:0002204 Pulmonary embolism 1
HP:0002240 Hepatomegaly 1
HP:0002249 Melena 1
HP:0002352 Leukoencephalopathy 1
HP:0002592 Gastric ulcer 1
HP:0002653 Bone pain 1
HP:0002754 Osteomyelitis 1
HP:0002781 Upper airway obstruction 1
HP:0002870 Obstructive sleep apnea 1
HP:0002955 Granulomatosis 1
HP:0002961 Dysgammaglobulinemia 1
HP:0003074 Hyperglycemia 1
HP:0003401 Paresthesia 1
HP:0003419 Low back pain 1
HP:0003470 Paralysis 1
HP:0004389 Intestinal pseudo-obstruction 1
HP:0005214 Intestinal obstruction 1
HP:0005263 Gastritis 1
HP:0005374 Cellular immunodeficiency 1
HP:0005550 Chronic lymphatic leukemia 1
HP:0005987 Multinodular goiter 1
HP:0007141 Sensorimotor neuropathy 1
HP:0008200 Primary hyperparathyroidism 1
HP:0010280 Stomatitis 1
HP:0010307 Stridor 1
HP:0010628 Facial palsy 1
HP:0011896 Subconjunctival hemorrhage 1
HP:0012032 Lipoma 1
HP:0012050 Anasarca 1
HP:0012057 Superficial spreading melanoma 1
HP:0012062 Bone cyst 1
HP:0012089 Arteritis 1
HP:0012384 Rhinitis 1
HP:0012587 Macroscopic hematuria 1
HP:0012636 Retinal vein occlusion 1
HP:0012740 Papilloma 1
HP:0020110 Bone fracture 1
HP:0025289 Cervical lymphadenopathy 1
HP:0025406 Asthenia 1
HP:0030169 Gastric varix 1
HP:0030358 Non-small cell lung carcinoma 1
HP:0030433 Osteoid osteoma 1
HP:0030838 Hip pain 1
HP:0031003 Polyneuritis 1
HP:0031207 Hepatic hemangioma 1
HP:0031501 Pelvic mass 1
HP:0032026 Anetoderma 1
HP:0032061 Hypereosinophilia 1
HP:0032282 Contact dermatitis 1
HP:0032408 Breast lump 1
HP:0040276 Adenocarcinoma of the colon 1
HP:0100518 Dysuria 1
HP:0100561 Spinal cord lesion 1
HP:0100750 Atelectasis 1
HP:0200034 Papule 1


Causative gene(s) retrieved from Orphanet

    Total: 0

Gene Symbol Gene Name Entrez Gene ID